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Cited by 225Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia.

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Ginsberg, H, Kimmerling, G, Olefsky, J M, Reaven, G M·1975·Journal of Clinical Investigation
DOI 10.1172/jci107951PMC PMC301772
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Abstract

We have used a continuous intravenous infusion of glucose (6 mg/kg/min), insulin (80 mU/min), epinephrine (6 mug/min), and propranolol (0.08 mg/min) to directly assess insulin resistance in 14 untreated adult onset diabetics with a mean (plus or minus SE) fasting plasma glucose level of 217 plus or minus 17 mg/100 ml. During the infusion endogenous insulin secretion is inhibited and steady-state plasma glucose and insulin levels are achieved after 90 min. Since similar steady-state levels of plasma insulin are achieved in all subjects, the plasma glucose concentration observed during the steady-state period is a measure of an individual's insulin resistance. Under these conditions, the mean (plus or minus SE) steady-state plasma glucose level of the 14 diabetic patients was 350 plus or minus 16 mg/100 ml, while that of 12 normal subjects was 121 plus or minus 4 mg/100 ml. Additional studies were performed in which control subjects and patients with diabetes had their fasting plasma glucose levels acutely raised or lowered to comparable levels before receiving the basic infusion mixture of glucose, insulin, epinephrine, and propranolol. The results of these studies indicated that differences in initial plasma glucose levels could not account for the different glucose responses of the two groups to the basic infusion. Finally, the mean (plus or minus SE) steady-state plasma glucose level of 104 plus or minus 17 mg/100 ml observed during the same basic infusion in five patients with fasting hyperglycemia (mean plus or minus SE, 142 plus or minus 12 mg/100 ml) secondary to chronic pancreatitis suggested that neither chronic hyperglycemia nor hypoinsulinemia per se necessarily lead to insulin resistance. These results demonstrate that marked insulin resistance exists in adult onset diabetics with fasting hyperglycemia. Since previous studies have documented the presence of insulin resistance in patients with chemical diabetes, the possibility exists that insulin resistance may be characteristic of adult onset diabetes mellitus.

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Metadata

Authors
Ginsberg, H., Kimmerling, G., Olefsky, J. M., & Reaven, G. M.
Affiliations
United States Department of Veterans Affairs (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1975-03-01
Volume
55
Issue
3
Pages
454-461
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci107951
PMC
PMC301772
OpenAlex
W2055493265
Cited by
225
References
20
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 2 · 2012: 6
FWCI
5.89
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
insulin resistance, adult-onset diabetes mellitus, fasting hyperglycemia, type 2 diabetes, steady-state plasma glucose, epinephrine, propranolol, chronic pancreatitis, hypoinsulinemia, endogenous insulin secretion
MeSH terms
Adult, Aged, Chronic Disease, Diabetes Mellitus, Epinephrine, Fasting, Female, Glucose, Humans, Hyperglycemia, Insulin, Insulin Resistance, Male, Middle Aged, Pancreatitis, Propranolol, Diabetes Complications

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