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Cited by 310

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Dietary-induced alterations in thyroid hormone metabolism during overnutrition.

Open access
Danforth, E, Horton, E S, O'Connell, M, Sims, E A, Burger, A G, Ingbar, S H, Braverman, L, Vagenakis, A G·1979·Journal of Clinical Investigation
DOI 10.1172/jci109590
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Abstract

Diet-induced alterations in thyroid hormone concentrations have been found in studies of long-term (7 mo) overfeeding in man (the Vermont Study). In these studies of weight gain in normal weight volunteers, increased calories were required to maintain weight after gain over and above that predicted from their increased size. This was associated with increased concentrations of triiodothyronine (T3). No change in the caloric requirement to maintain weight or concentrations of T3 was found after long-term (3 mo) fat overfeeding. In studies of short-term overfeeding (3 wk) the serum concentrations of T3 and its metabolic clearance were increased, resulting in a marked increase in the production rate of T3 irrespective of the composition of the diet overfed (carbohydrate 29.6 +/- 2.1 to 54.0 +/- 3.3, fat 28.2 +/- 3.7 to 49.1 +/- 3.4, and protein 31.2 +/- 2.1 to 53.2 +/- 3.7 microgram/d per 70 kg). Thyroxine production was unaltered by overfeeding (93.7 +/- 6.5 vs. 89.2 +/- 4.9 microgram/d per 70 kg). It is still speculative whether these dietary-induced alterations in thyroid hormone metabolism are responsible for the simultaneously increased expenditure of energy in these subjects and therefore might represent an important physiological adaptation in times of caloric affluence. During the weight-maintenance phases of the long-term overfeeding studies, concentrations of T3 were increased when carbohydrate was isocalorically substituted for fat in the diet. In short-term studies the peripheral concentrations of T3 and reverse T3 found during fasting were mimicked in direction, if not in degree, with equal or hypocaloric diets restricted in carbohydrate were fed. It is apparent from these studies that the caloric content as well as the composition of the diet, specifically, the carbohydrate content, can be important factors in regulating the peripheral metabolism of thyroid hormones.

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Metadata

Authors
Danforth, E., Horton, E. S., O'Connell, M., Sims, E. A., Burger, A. G., Ingbar, S. H., Braverman, L., & Vagenakis, A. G.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1979-11-01
Volume
64
Issue
5
Pages
1336-1347
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci109590
OpenAlex
W2144999134
Cited by
310
References
41
FWCI
10.95
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Dietary-induced alterations in thyroid hormone metabolism during overnutrition. https://app.cochat.ai/papers/10.1172/jci109590
The paper
Danforth, E., Horton, E. S., O'Connell, M., Sims, E. A., Burger, A. G., Ingbar, S. H., Braverman, L., & Vagenakis, A. G. (1979). Dietary-induced alterations in thyroid hormone metabolism during overnutrition. Journal of Clinical Investigation. https://doi.org/10.1172/jci109590

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.