The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.
Open accessAbstract
Modification of low density lipoproteins by human arterial smooth muscle cells was characterized by increased electrophoretic mobility and increased content of malondialdehyde-like oxidation products reactive with thiobarbituric acid. Lipoprotein modification was promoted by micromolar concentrations of iron or copper in the culture medium and was metal ion concentration- and time-dependent. The ability of diverse media to promote smooth muscle cell-mediated low density lipoprotein modification correlated with their iron concentration. Therefore, metal ion concentration of culture media contributes substantially to low density lipoprotein modification in vitro. Human monocyte-derived macrophages took up and esterified the cholesterol from modified low density lipoprotein more extensively than from native low density lipoprotein. Metal ion-mediated modification of low density lipoprotein may be a contributing factor to the pathogenesis of arteriosclerosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brown, M. S., Ho, Y. K., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70568-7 · Cited by 722
Cited by
Daugherty, A., Dunn, J. L., Rateri, D. L., & Heinecke, J. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117342 · Cited by 1,269
Self-citationDisruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
Cyrus, T., Witztum, J. L., Rader, D. J., Tangirala, R., Fazio, S., Linton, M. F., & Funk, C. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5897 · Cited by 523
Body Iron Stores and the Risk of Carotid Atherosclerosis: Prospective Results From the Bruneck Study
Kiechl, S., Willeit, J., Egger, G., Poewe, W., & Oberhollenzer, F. (1997) · Circulation · doi:10.1161/01.cir.96.10.3300 · Cited by 390
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
Altamura, S., & Muckenthaler, M. U. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1010 · Cited by 369
Stadler, N., Lindner, R. A., & Davies, M. J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000124892.90999.cb · Cited by 310
Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis
Day, S. M., Duquaine, D., Mundada, L. V., Menon, R. G., Khan, B. V., Rajagopalan, S., & Fay, W. P. (2003) · Circulation · doi:10.1161/01.cir.0000066910.02844.d0 · Cited by 192
Iron-Deficient Diet Reduces Atherosclerotic Lesions in ApoE-Deficient Mice
Lee, T.-S., Shiao, M.-S., Pan, C.-C., & Chau, L.-Y. (1999) · Circulation · doi:10.1161/01.cir.99.9.1222 · Cited by 179
Jenner, A., Ren, M., Rajendran, R., Ning, P., Huat, B. T. K., Watt, F., & Halliwell, B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.024 · Cited by 96
A Protective Role for Kidney Apolipoprotein E
Chen, G., Paka, L., Kako, Y., Singhal, P., Duan, W., & Pillarisetti, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104879200 · Cited by 84
Thomas, C. E. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90256-u · Cited by 67
Stanley, N., Stadler, N., Woods, A. A., Bannon, P. G., & Davies, M. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.031 · Cited by 51
Vitamin E Inhibits Lysophosphatidylcholine-Induced Endothelial Dysfunction and Platelet Activation
Murohara, T., Ikeda, H., Katoh, A., Takajo, Y., Otsuka, Y., Haramaki, N., & Imaizumi, T. (2002) · Antioxidants & Redox Signaling · doi:10.1089/152308602760598945 · Cited by 19
Modulation of lead toxicity bySpirulina fusiformis
Shastri, D., Kumar, M., & Kumar, A. (1999) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199905)13:3<258::aid-ptr438>3.0.co;2-2
Metadata
- Authors
- Heinecke, J. W., Rosen, H., & Chait, A.
- Venue
- Journal of Clinical Investigation
- Published
- 1984-11-01
- Volume
- 74
- Issue
- 5
- Pages
- 1890-1894
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2017315967
- Cited by
- 536
- References
- 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
