Prostaglandin E 2 induces fibroblast apoptosis by modulating multiple survival pathways

Although the lipid mediator prostaglandin E 2 (PGE 2 ) exerts antifibrotic effects by inhibiting multiple fibroblast functions, its ability to regulate fibroblast survival is unknown. Here, we examined the effects of this prostanoid on apoptosis and apoptosis pathways in normal and fibrotic lung …