The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.
Open accessAbstract
Synovial inflammation is often associated with systemic changes, such as increased levels of acute phase proteins and hypergammaglobulinemia, which cannot be explained by the cytokines described in synovial fluids and synoviocyte secretions. Interleukin 6 (IL-6) has recently been characterized as a mediator of multiple inflammatory responses. This cytokine promotes T and B lymphocyte growth and differentiation, and acute phase protein synthesis. We therefore examined IL-6 production by human synoviocytes and its presence in synovial fluids. In vitro, synoviocytes spontaneously released IL-6, which was increased by IL-1 and tumor necrosis factor-alpha. Synoviocyte-derived IL-6 activity was able to induce hybridoma-plasmacytoma proliferation, and immunoglobulin and acute-phase protein synthesis. The synovial fluids from patients with diverse arthropathies contained IL-6 activity, but higher levels were present in inflammatory arthropathies than in osteoarthritis. These results demonstrate that synoviocytes are a potent source of IL-6, which can contribute to important manifestations of inflammatory arthropathies.
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Cites
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Metadata
- Authors
- Guerne, P. A., Zuraw, B. L., Vaughan, J. H., Carson, D. A., & Lotz, M.
- Venue
- Journal of Clinical Investigation
- Published
- 1989-02-01
- Volume
- 83
- Issue
- 2
- Pages
- 585-592
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2150602579
- Cited by
- 513
- References
- 43
- FWCI
- 34.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guerne, P. A., Zuraw, B. L., Vaughan, J. H., Carson, D. A., & Lotz, M. (1989). Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. Journal of Clinical Investigation. https://doi.org/10.1172/jci113921
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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