The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Influence of body fat distribution on free fatty acid metabolism in obesity.
Open accessAbstract
UNLABELLED: In order to determine whether differences in body fat distribution result in specific abnormalities of free fatty acid (FFA) metabolism, palmitate turnover, a measure of systemic adipose tissue lipolysis, was measured in 10 women with upper body obesity, 9 women with lower body obesity, and 8 nonobese women under overnight postabsorptive (basal), epinephrine stimulated and insulin suppressed conditions. RESULTS: Upper body obese women had greater (P less than 0.005) basal palmitate turnover than lower body obese or nonobese women (2.8 +/- 0.2 vs. 2.1 +/- 0.2 vs. 1.8 +/- 0.2 mumol.kg lean body mass (LBM)-1.min-1, respectively), but a reduced (P less than 0.05) net lipolytic response to epinephrine (59 +/- 7 vs. 79 +/- 5 vs. 81 +/- 7 mumol palmitate/kg LBM, respectively). Both types of obesity were associated with impaired suppression of FFA turnover in response to euglycemic hyperinsulinemia compared to nonobese women (P less than 0.005). These specific differences in FFA metabolism may reflect adipocyte heterogeneity, which may in turn affect the metabolic aberrations associated with different types of obesity. These findings emphasize the need to characterize obese subjects before studies.
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“An interesting feature of upper-body obesity is an unusually high release of nonesterified fatty acids from adipose tissue 12,14,28 ; this contributes to accumulation of lipid in sites other than adipose tissue.”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [28]
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“Regardless of the relative contributions of visceral fat and abdominal subcutaneous fat to insulin resistance, a pattern of abdominal (or upper-body) obesity correlates more strongly with insulin resistance and the metabolic syndrome than does lower-body obesity.28”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [28]
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Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
A comprehensive review on metabolic syndrome
Kaur, J. (2014) · Cardiology Research and Practice · doi:10.1155/2014/943162 · Cited by 1,889
RetractedChait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Lewis, G. F., Carpentier, A. C., Adeli, K., & Giacca, A. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0461 · Cited by 1,370
Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300
Metadata
- Authors
- Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M.
- Affiliations
- Mayo Clinic (US)
- Washington University in St. Louis (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1989-04-01
- Volume
- 83
- Issue
- 4
- Pages
- 1168-1173
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC303803
- OpenAlex
- W2087710728
- Cited by
- 683
- References
- 38
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 21 · 2023: 15 · 2022: 23 · 2021: 22 · 2020: 22 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 23 · 2015: 24 · 2014: 27 · 2013: 32 · 2012: 24
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 26989, DK 29953, DK-38029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- body fat distribution, upper body obesity, lower body obesity, free fatty acid metabolism, adipose tissue lipolysis, hyperinsulinemic-euglycemic clamp, adipocyte heterogeneity
- MeSH terms
- Adipose Tissue, Adult, Blood Glucose, Body Composition, Epinephrine, Fatty Acids, Nonesterified, Female, Humans, Infusions, Intravenous, Insulin, Kinetics, Obesity, Palmitates, Triglycerides
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