Cited by 683Lipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Influence of body fat distribution on free fatty acid metabolism in obesity.

Open access

Jensen, M D, Haymond, M W, Rizza, R A, Cryer, P E, Miles, J M·1989·Journal of Clinical Investigation

DOI 10.1172/jci113997PMC PMC303803

Open this paper in CoChat — free account Open PDF

Abstract

UNLABELLED: In order to determine whether differences in body fat distribution result in specific abnormalities of free fatty acid (FFA) metabolism, palmitate turnover, a measure of systemic adipose tissue lipolysis, was measured in 10 women with upper body obesity, 9 women with lower body obesity, and 8 nonobese women under overnight postabsorptive (basal), epinephrine stimulated and insulin suppressed conditions. RESULTS: Upper body obese women had greater (P less than 0.005) basal palmitate turnover than lower body obese or nonobese women (2.8 +/- 0.2 vs. 2.1 +/- 0.2 vs. 1.8 +/- 0.2 mumol.kg lean body mass (LBM)-1.min-1, respectively), but a reduced (P less than 0.05) net lipolytic response to epinephrine (59 +/- 7 vs. 79 +/- 5 vs. 81 +/- 7 mumol palmitate/kg LBM, respectively). Both types of obesity were associated with impaired suppression of FFA turnover in response to euglycemic hyperinsulinemia compared to nonobese women (P less than 0.005). These specific differences in FFA metabolism may reflect adipocyte heterogeneity, which may in turn affect the metabolic aberrations associated with different types of obesity. These findings emphasize the need to characterize obese subjects before studies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci113997

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Coated Charcoal Immunoassay of Insulin
Herbert, V. D., Lau, K., Gottlieb, C. W., & Bleicher, S. J. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1375 · Cited by 2,969
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
Starvation in Man
Sherwood, L. M., Parris, E. E., & Cahill, G. F. (1970) · New England Journal of Medicine · doi:10.1056/nejm197003192821209 · Cited by 1,268
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber.
Ravussin, E., Lillioja, S., Anderson, T. E., Christin, L., & Bogardus, C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112749 · Cited by 1,166
Effect of fatty acids on glucose production and utilization in man.
Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050
Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man
Abumrad, N. N., Rabin, D. D., Diamond, M. P., & LACY, W. W. (1981) · Metabolism · doi:10.1016/0026-0495(81)90074-3 · Cited by 569
TURNOVER RATE AND OXIDATION OF FREE FATTY ACIDS OF BLOOD PLASMA IN MAN DURING EXERCISE: STUDIES DURING CONTINUOUS INFUSION OF PALMITATE-1-C14*
Havel, R. J., Naimark, A., & Borchgrevink, C. F. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104791 · Cited by 417

Show all 38 references

Research works printed but not linked: 2

Faloona, G., and R. H. Unger. 1974. Glucagon. In Methods of Hormone Radioimmunoassay. B. Jaffe and H. Behrman, editors. Aca- demic Press, Inc., New York. 317-330.
Peake, G. T. 1974. Growth hormone. In Methods of Hormone Radioimmunoassay. B. Jaffe and H. Behrman, editors. Academic Press, New York. 103-121.

Sorted by citations

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
A comprehensive review on metabolic syndrome
Kaur, J. (2014) · Cardiology Research and Practice · doi:10.1155/2014/943162 · Cited by 1,889
Retracted
Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
Lewis, G. F., Carpentier, A. C., Adeli, K., & Giacca, A. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0461 · Cited by 1,370
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300
The Obesity Epidemic: Pathophysiology and Consequences of Obesity
Pi‐Sunyer, F. X. (2002) · Obesity Research · doi:10.1038/oby.2002.202 · Cited by 885
Obesity and Free Fatty Acids
Boden, G. H. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.007 · Cited by 852
Obesity, insulin resistance and free fatty acids
Boden, G. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283444b09 · Cited by 848
Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint
Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 797
Relationships of generalized and regional adiposity to insulin sensitivity in men.
Abate, N., Garg, A., Peshock, R. M., Stray-Gundersen, J., & Grundy, S. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118083 · Cited by 759
Role of Body Fat Distribution and the Metabolic Complications of Obesity
Jensen, M. D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1585 · Cited by 715
Self-citation
Ruminant Adaptation to Negative Energy Balance
Herdt, T. H. (2000) · Veterinary Clinics of North America Food Animal Practice · doi:10.1016/s0749-0720(15)30102-x · Cited by 657
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus
Gerber, P. A., & Rutter, G. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6755 · Cited by 654
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Michelet, X., Dyck, L., Hogan, A. E., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0251-7 · Cited by 651
Hypertriglyceridemia, insulin resistance, and the metabolic syndrome
Grundy, S. M. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00211-8 · Cited by 610
What aspects of body fat are particularly hazardous and how do we measure them?
Snijder, M. B., van Dam, R. M., Visser, M., & Seidell, J. C. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi253 · Cited by 600
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
Holm, C., Østerlund, T., Laurell, H., & Contreras, J. A. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.365 · Cited by 572
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
Saponaro, C., Gaggini, M., Carli, F., & Gastaldelli, A. (2015) · Nutrients · doi:10.3390/nu7115475 · Cited by 558
Visceral Obesity: A “Civilization Syndrome”
Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00614.x · Cited by 483
Genetic and Nongenetic Determinants of Regional Fat Distribution
Bouchard, C., Després, J., & Mauriège, P. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-72 · Cited by 489
Lipids in the tumor microenvironment: From cancer progression to treatment
Corn, K. C., Windham, M. A., & Rafat, M. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101055 · Cited by 486
Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice
Saberi, M., Woods, N.-B., de Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., Verma, I. M., & Olefsky, J. M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.006 · Cited by 456
“Because obesity is characterized by elevated fatty acid levels (Horowitz et al., 1999; Jensen et al., 1989), the fact that fatty acids can stimulate a receptor that activates inflammatory pathways provides a potentially important link between obesity, inflammation, and insulin resistance.”
Background
Differences in Lipolysis between Human Subcutaneous and Omental Adipose Tissues
Arner, P. (1995) · Annals of Medicine · doi:10.3109/07853899709002451 · Cited by 457
Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets
Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450
Self-citation
Association of Body Fat Distribution and Cardiovascular Risk Factors in Children and Adolescents
Daniels, S. R., Morrison, J. A., Sprecher, D. L., Khoury, P. R., & Kimball, T. R. (1999) · Circulation · doi:10.1161/01.cir.99.4.541 · Cited by 444
Diagnosis and management of the metabolic syndrome
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000200416.65370.a0 · Cited by 437
Pathogenesis of steatohepatitis
Day, C. P. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2002.0333 · Cited by 434
Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men
Nakamura, T., Tokunaga, K., Shimomura, I., Nishida, M., Yoshida, S., Kotani, K., Islam, A. H. M. W., Keno, Y., Kobatake, T., Nagai, Y., et al. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90025-6 · Cited by 429
Role of free fatty acids in endothelial dysfunction
Ghosh, A., Gao, L., Thakur, A., Siu, P. M., & Lai, C. W. K. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0357-5 · Cited by 432
In vivo regulation of lipolysis in humans.
Coppack, S. W., Jensen, M. D., & Miles, J. M. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41207-6 · Cited by 411
Self-citation
Multifactorial causation of obesity: implications for prevention
Grundy, S. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.563s · Cited by 403
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461
Surgical removal of visceral fat reverses hepatic insulin resistance.
Barzilai, N., She, L., Liu, B. Q., Vuguin, P. M., Cohen, P., Wang, J., & Rossetti, L. (1999) · Diabetes · doi:10.2337/diabetes.48.1.94 · Cited by 377
Adipocyte Lipases and Defect of Lipolysis in Human Obesity
Langin, D., Dicker, A., Tavernier, G., Hoffstedt, J., Mairal, A., Rydén, M., Arner, E., Sicard, A., Jenkins, C. M., Viguerie, N., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3190 · Cited by 371
Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease
Azzu, V., Vacca, M., Virtue, S., Allison, M., & Vidal-Puig, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.054 · Cited by 369
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease
ter Horst, K. W., & Serlie, M. J. M. (2017) · Nutrients · doi:10.3390/nu9090981 · Cited by 379
Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots
Chusyd, D. E., Wang, D., Huffman, D. M., & Nagy, T. R. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00010 · Cited by 379
Relationship between Generalized and Upper Body Obesity to Insulin Resistance in Asian Indian Men
Chandalia, M., Abate, N., Garg, A., Stray‐Gundersen, J., & Grundy, S. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.7.5817 · Cited by 402
Fat Depots, Free Fatty Acids, and Dyslipidemia
Ebbert, J. O., & Jensen, M. D. (2013) · Nutrients · doi:10.3390/nu5020498 · Cited by 355
Self-citation
Metabolic effects of obesity: A review
Singla, P. (2010) · World Journal of Diabetes · doi:10.4239/wjd.v1.i3.76 · Cited by 341
Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus
Björntorp, P. A., Holm, G., & Rosmond, R. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00067.x · Cited by 324
Skeletal muscle utilization of free fatty acids in women with visceral obesity.
Colberg, S. R., Simoneau, J. A., Thaete, F. L., & Kelley, D. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117864 · Cited by 320
Growth hormone in obesity
Scacchi, M., Pincelli, A. I., & Cavagnini, F. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800807 · Cited by 317
Influence of body fat content and distribution on variation in metabolic risk
Vega, G. L., Adams-Huet, B., Peshock, R., Willett, D., Shah, B., & Grundy, S. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0814 · Cited by 312
Body fat distribution, insulin resistance, and metabolic diseases
Björntorp, P. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00191-3 · Cited by 470
Oxidative stress and metabolic pathologies: from an adipocentric point of view
Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291
Visceral obesity and metabolic syndrome
Bosello, O., & Zamboni, M. M. (2000) · Obesity Reviews · doi:10.1046/j.1467-789x.2000.00008.x · Cited by 285
Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease?
Björntorp, P. A. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00431.x · Cited by 283
Sex dimorphism and depot differences in adipose tissue function
White, U. A., & Tchoukalova, Y. D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.006 · Cited by 296
Adipose tissue metabolism in obesity: Lipase action in vivo before and after a mixed meal
Coppack, S. W., Evans, R. D., Fisher, R. M., Frayn, K. N., Gibbons, G. F., Humphreys, S. M., Kirk, M. L., Potts, J. L., & Hockaday, T. D. R. (1992) · Metabolism · doi:10.1016/0026-0495(92)90269-g · Cited by 278
Effects of Diet and Physical Activity on Adiposity and Body Fat Distribution: Implications for the Prevention of Cardiovascular Disease
Després, J., & Lamarche, B. (1993) · Nutrition Research Reviews · doi:10.1079/nrr19930010 · Cited by 273
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
Barzilai, N., Banerjee, S., Hawkins, M. A., Chen, W., & Rossetti, L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci485 · Cited by 277
What is lipotoxicity?
Engin, A. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_8 · Cited by 260
Effects of body fat distribution on regional lipolysis in obesity.
Martin, M. L., & Jensen, M. D. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115345 · Cited by 252
Self-citation
Free fatty acids, insulin resistance, and type 2 diabetes mellitus
Boden, G. (1999) · Proceedings of the Association of American Physicians · doi:10.1046/j.1525-1381.1999.99220.x · Cited by 246
A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.
Lönnqvist, F., Thome, A. N., NILSELL, K., Hoffstedt, J., & Arner, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117758 · Cited by 251
Mechanisms of insulin resistance related to white, beige, and brown adipocytes
Czech, M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.014 · Cited by 258
Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans
Williams, I. L., Wheatcroft, S. B., Shah, A. M., & Kearney, M. T. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801995 · Cited by 265
Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis
Medina, J., Fernández-Salazar, L. I., García-Buey, L., & Moreno‐Otero, R. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2057 · Cited by 229
Fatty acid mobilization from adipose tissue during exercise
Horowitz, J. F. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00143-7 · Cited by 232
Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes
Bézaire, V., Mairal, A., Ribet, C., Lefort, C., Girousse, A., Jocken, J. W. E., Laurencikiene, J., Anesia, R., Rodriguez, A., Rydén, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008631 · Cited by 219
Metabolic Complications of Obesity
Grundy, S. M. (2000) · Endocrine · doi:10.1385/endo:13:2:155 · Cited by 217
Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism
Shojaee‐Moradie, F., Baynes, K., Pentecost, C., Bell, J. D., Thomas, E. L., Jackson, N. C., Stolinski, M., Whyte, M., Lovell, D., Bowes, S. B., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0498-7 · Cited by 209
Are Increased Plasma Non-Esterified Fatty Acid Concentrations a Risk Marker for Coronary Heart Disease and other Chronic Diseases?
Frayn, K. N., Williams, C. M., & Arner, P. (1996) · Clinical Science · doi:10.1042/cs0900243 · Cited by 202
Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults
Ryan, B. J., Schleh, M. W., Ahn, C., Ludzki, A. C., Gillen, J. B., Varshney, P., Pelt, D. W. V., Pitchford, L. M., Chenevert, T. L., Gioscia‐Ryan, R. A., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa345 · Cited by 228
Glycerol production in subcutaneous adipose tissue in lean and obese humans.
Jansson, P., Larsson, A., Smith, U., & Lönnroth, P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115756 · Cited by 196
Thematic review series: Patient-Oriented Research. Free fatty acid metabolism in human obesity
Koutsari, C., & Jensen, M. D. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600011-jlr200 · Cited by 201
Self-citation
Gender differences in regional fatty acid metabolism before and after meal ingestion.
Jensen, M. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118285 · Cited by 191
Self-citation
Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism
Dullaart, R. P. F., Sluiter, W. J., Dikkeschei, L. D., Hoogenberg, K., & van Tol, A. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb00987.x · Cited by 195
Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women
Mittendorfer, B., Magkos, F., Fabbrini, E., Mohammed, B. S., & Klein, S. (2009) · Obesity · doi:10.1038/oby.2009.224 · Cited by 199
Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones
Geisler, C. E., & Renquist, B. J. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0513 · Cited by 200
Adipose tissue and metabolic syndrome: too much, too little or neither
Grundy, S. M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12519 · Cited by 187
Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta 2 -adrenoceptors
Reynisdottir, S., Wahrenberg, H., Carlstr�m, K., R�ssner, S., & Arner, P. (1994) · Diabetologia · doi:10.1007/bf00408482 · Cited by 191
Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells
Kranendonk, M. E. G., Visseren, F. L. J., van Herwaarden, J. A., Hoen, E. N. M. N., de Jager, W., Wauben, M. H. M., & Kalkhoven, E. (2014) · Obesity · doi:10.1002/oby.20847 · Cited by 195
Nonalcoholic fatty liver disease
Krawczyk, M. J., Bonfrate, L., & Portincasa, P. (2010) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.08.005 · Cited by 193
The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream)
Piers, L., Walker, K., Stoney, R., Soares, M. J., & O’Dea, K. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801993 · Cited by 187
Non‐alcoholic steatohepatitis: Definitions and pathogenesis
Day, C., & SAKSENA, S. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.17.s3.31.x · Cited by 187
Aerobic exercise training reduces epicardial fat in obese men
Kim, M.-K., Tomita, T., Kim, M.-J., Sasai, H., Maeda, S., & Tanaka, K. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90756.2008 · Cited by 186
The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids
El‐Moselhy, M. A., Taye, A., Sharkawi, S. S., El-Sisi, S. F., & Ahmed, A. F. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.02.004 · Cited by 185
Distinct Developmental Signatures of Human Abdominal and Gluteal Subcutaneous Adipose Tissue Depots
Karastergiou, K., Fried, S. K., Xie, H., Lee, M., Divoux, A., Rosencrantz, M. A., Chang, R. J., & Smith, S. R. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2953 · Cited by 182
Metabolic syndrome and cardiovascular risk
Alshehri, A. (2010) · Journal of Family and Community Medicine · doi:10.4103/1319-1683.71987 · Cited by 184
The importance of free fatty acids in the development of Type 2 diabetes
Wilding, J. P. H. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02186.x · Cited by 178
Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection
Cohen, P. G. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1169 · Cited by 172
The interplay of factors in metabolic syndrome: understanding its roots and complexity
Islam, M. S., Wei, P., Suzauddula, M., Nime, I., Feroz, F., Acharjee, M., & Pan, F. (2024) · Molecular Medicine · doi:10.1186/s10020-024-01019-y · Cited by 221
Increased collagen content in insulin-resistant skeletal muscle
Berria, R., Wang, L., Richardson, D. K., Finlayson, J., Belfort, R., Pratipanawatr, T., De Filippis, E. A., Kashyap, S., & Mandarino, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00202.2005 · Cited by 171
Body fat distribution, rather than overall adiposity, influences serum lipids and lipoproteins in healthy men independently of age
Walton, C., Lees, B., Crook, D., Worthington, M., Godsland, I. F., & Stevenson, J. C. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80220-4 · Cited by 170
Insulin resistance and the sympathetic nervous system
Egan, B. M. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0028-7 · Cited by 172
Palmitic acid is an intracellular signaling molecule involved in disease development
Fatima, S., Hu, X., Gong, R., Huang, C., Chen, M., Wong, H. L. X., Bian, Z., & Kwan, H. Y. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03092-7 · Cited by 171
Multiple lipolysis defects in the insulin resistance (metabolic) syndrome.
Reynisdottir, S., Ellerfeldt, K., Wahrenberg, H., Lithell, H., & Arner, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117271 · Cited by 164
The Role of Physical Activity in the Prevention and Management of Obesity
Rippe, J. M., & Hess, S. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00708-1 · Cited by 163
The case of visceral fat: argument for the defense
Klein, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422028 · Cited by 206
Sex Differences in Visceral Fat Lipolysis and Metabolic Complications of Obesity
Lönnqvist, F., Thörne, A., Large, V., & Arner, P. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1472 · Cited by 160
LIPOLYSIS:Contribution from Regional Fat
Jensen, M. D. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.127 · Cited by 157
Self-citation
Sex Differences in Adipose Tissue Function
Gavin, K. M., & Bessesen, D. H. (2020) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2020.02.008 · Cited by 173
Plasma Free Fatty Acid Concentration as a Modifiable Risk Factor for Metabolic Disease
Henderson, G. C. (2021) · Nutrients · doi:10.3390/nu13082590 · Cited by 152
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
Mowers, J. C., Uhm, M., Reilly, S. M., Simon, J., Leto, D. E., Chiang, S.-H., Chang, L. C., & Saltiel, A. R. (2013) · eLife · doi:10.7554/elife.01119 · Cited by 152
Free fatty acids FFA a link between obesity and insulin resistance
Boden, G. H. (1998) · Frontiers in bioscience · doi:10.2741/a272 · Cited by 148
Adipokines at the crossroad between obesity and cardiovascular disease
Morel, S., Kwak, B. R., Rohner‐Jeanrenaud, F., Steffens, S., & Molica, F. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-06-0513 · Cited by 149
Nonalcoholic fatty liver disease and liver transplantation
Angulo, P. (2006) · Liver Transplantation · doi:10.1002/lt.20738 · Cited by 140
Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women
Horowitz, J. F., & Klein, S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e1144 · Cited by 138

Authors: Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M.
Affiliations: Mayo Clinic (US)
Washington University in St. Louis (US)
ORCID: Jensen, M D
Haymond, M W
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1989-04-01
Volume: 83
Issue: 4
Pages: 1168-1173
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci113997
PMC: PMC303803
OpenAlex: W2087710728
Cited by: 683
References: 38
Citations by year: 2026: 7 · 2025: 5 · 2024: 21 · 2023: 15 · 2022: 23 · 2021: 22 · 2020: 22 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 23 · 2015: 24 · 2014: 27 · 2013: 32 · 2012: 24
FWCI: 5.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Mayo Foundation for Medical Education and Research
National Institute of Diabetes and Digestive and Kidney Diseases (DK 26989, DK 29953, DK-38029)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: body fat distribution, upper body obesity, lower body obesity, free fatty acid metabolism, adipose tissue lipolysis, hyperinsulinemic-euglycemic clamp, adipocyte heterogeneity
MeSH terms: Adipose Tissue, Adult, Blood Glucose, Body Composition, Epinephrine, Fatty Acids, Nonesterified, Female, Humans, Infusions, Intravenous, Insulin, Kinetics, Obesity, Palmitates, Triglycerides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Influence of body fat distribution on free fatty acid metabolism in obesity.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks