Effects of body fat distribution on regional lipolysis in obesity.
Open accessAbstract
UNLABELLED: To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ([1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) age-matched premenopausal women in the overnight postabsorptive state. Splanchnic palmitate release was determined in 16 of these subjects. RESULTS: total palmitate release was greater in UB Ob (P less than 0.005) than LB Ob or Non Ob women (161 +/- 16 vs. 111 +/- 9 vs. 92 +/- 9 mumol/min, respectively). Despite increased leg fat mass in obese women, leg palmitate release was similar in each group. Therefore, leg fat palmitate release was greater in Non Ob women than LB Ob (P less than 0.01) or UB Ob (P = 0.06) women (3.7 +/- 0.3 vs. 2.4 +/- 0.2 vs. 2.7 +/- 0.2 mumol.kg fat-1.min-1, respectively). Upper body fat palmitate release was less (P less than 0.01) in LB Ob than Non Ob or UB Ob women (3.0 +/- 0.4 vs. 5.0 +/- 0.3 vs. 4.9 +/- 0.4 mumol.kg fat-1.min-1, respectively). Splanchnic palmitate release accounted for 20-32% of upper body fat palmitate release in each group (P = NS between groups). Leg fat palmitate release was significantly less than upper body fat palmitate release. We conclude that the major difference in resting FFA metabolism between UB Ob and LB Ob women is the ability of the later to down-regulate upper body fat lipolysis to maintain normal FFA availability.
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For both women and men, FFA release rates per kg are greater from upper body than from lower body subcutaneous adipose tissue.
“For both women (33) and men (67), FFA release rates per kg are greater from upper body than from lower body subcutaneous adipose tissue (Figure 4).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [33]
The authors pooled data from femoral artery, femoral vein, and hepatic vein catheterization studies to assess variability and sex differences in regional FFA release.
“We pooled data from femoral artery, femoral vein and hepatic vein catheterization studies that included measures of blood flow, body composition and isotopic tracer techniques to assess the variability and sex-differences regional FFA release (33, 65–70).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [33]
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Self-citation
- Authors
- Martin, M. L., & Jensen, M. D.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Jensen, M D
- Venue
- Journal of Clinical Investigation
- Published
- 1991-08-01
- Volume
- 88
- Issue
- 2
- Pages
- 609-613
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC295396
- OpenAlex
- W2102444737
- Cited by
- 252
- References
- 32
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 4 · 2013: 6 · 2012: 7
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- Mayo Foundation for Medical Education and Research
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 40484)
- National Center for Research Resources (RR 0585, M01RR000585)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- body fat distribution, obesity, upper body fat, leg fat, fatty acid metabolism, premenopausal women
- MeSH terms
- Adipose Tissue, Adult, Fatty Acids, Nonesterified, Female, Humans, Leg, Lipolysis, Mesentery, Obesity, Palmitic Acids, Palmitic Acid
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