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Cited by 469

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

Open access
Clerici, M, Hakim, F T, Venzon, D J, Blatt, S, Hendrix, C W, Wynn, T A, Shearer, G M·1993·Journal of Clinical Investigation
DOI 10.1172/jci116294
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Abstract

Infection with HIV results in an incremental loss of T helper cell (TH) function, which can occur years before CD4 cell numbers are critically reduced and AIDS is diagnosed. All TH function is not affected, however, because B cell activation and hypergammaglobulinema are also characteristic of this period. Recently, in a murine model of AIDS an early loss in production of the CD4 cytokines IL-2 and IFN-gamma was correlated with an increase in the B cell stimulatory cytokines IL-4, IL-5, and IL-10. We therefore assessed the production of IL-4 generated by PBL from HIV-seropositive (HIV+) individuals who did not have AIDS, yet who exhibited different TH functional categories based on their IL-2 production profiles. We observed that the decreases in recall antigen-stimulated IL-2 production were accompanied by an increase in IL-4 production. The loss of recall antigen-stimulated responses in HIV+ individuals could be reversed in vitro by anti-IL-4 antibody. Our results suggest that the TH functions assessed by IL-4 production replace the normally dominant TH function of antigen-stimulated IL-2 production in the progression toward AIDS, and raise the possibility of cytokine cross-regulation in AIDS therapy.

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Metadata

Authors
Clerici, M., Hakim, F. T., Venzon, D. J., Blatt, S., Hendrix, C. W., Wynn, T. A., & Shearer, G. M.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1993-03-01
Volume
91
Issue
3
Pages
759-765
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci116294
OpenAlex
W1963958510
Cited by
469
References
32
FWCI
19.46
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. https://app.cochat.ai/papers/10.1172/jci116294
The paper
Clerici, M., Hakim, F. T., Venzon, D. J., Blatt, S., Hendrix, C. W., Wynn, T. A., & Shearer, G. M. (1993). Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. Journal of Clinical Investigation. https://doi.org/10.1172/jci116294

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.