The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.
Open accessAbstract
Neutrophil transmigration across intestinal epithelia is thought to contribute to epithelial dysfunction and characterizes many inflammatory intestinal diseases. Neutrophils activated by factors, normally present in the lumen, release a neutrophil-derived secretagogue activity to which intestinal epithelia respond with an electrogenic chloride secretion, the transport event which underlies secretory diarrhea. Using sequential ultrafiltration, column chromatographic, and mass and Raman spectroscopic techniques, neutrophil-derived secretagogue was identified as 5'-AMP. Additional studies suggested that neutrophil-derived 5'-AMP is subsequently converted to adenosine at the epithelial cell surface by ecto-5'-nucleotidase and that adenosine subsequently activates intestinal secretion through adenosine receptors on the apical membrane of target intestinal epithelial cells. These findings suggest that this ATP metabolite may serve as a neutrophil-derived paracrine mediator that contributes to secretory diarrhea in states of intestinal inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Electrospray ionization–principles and practice
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1990) · Mass Spectrometry Reviews · doi:10.1002/mas.1280090103 · Cited by 1,569
A human colonic tumor cell line that maintains vectorial electrolyte transport
Dharmsathaphorn, K., McRoberts, J. A., Mandel, K. G., Tisdale, L. D., & Masui, H. (1984) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1984.246.2.g204 · Cited by 398
The multidrug resistance (mdr1) gene product functions as an ATP channel.
Abraham, E. H., Prat, A. G., Gerweck, L., Seneveratne, T., Arceci, R. J., Kramer, R., Guidotti, G., & Cantiello, H. F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.312 · Cited by 374
Crypts Are the Site of Intestinal Fluid and Electrolyte Secretion
Welsh, M. J., Smith, P. L., Fromm, M., & Frizzell, R. A. (1982) · Science · doi:10.1126/science.6293054 · Cited by 358
Parkos, C. A., Delp, C., Arnaout, M. A., & Madara, J. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115473 · Cited by 346
Self-citationMisumi, Y., Ogata, S., Hirose, S., & Ikehara, Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39958-2 · Cited by 133
Thomson, L., Ruedi, J. M., Glass, A. A., Moldenhauer, G., Mӧller, P., Low, M. G., Klemens, M. R., Massaia, M., & Lucas, A. H. (1990) · Tissue Antigens · doi:10.1111/j.1399-0039.1990.tb01750.x · Cited by 130
Mrsny, R. J., Volwerk, J. J., & Griffith, O. H. (1986) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(86)90111-8 · Cited by 100
Self-citationCl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue.
Madara, J., Parkos, C. A., Colgan, S. P., Macleod, J., Nash, S. V., Matthews, J. B., Delp, C., & Lencer, W. I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115800 · Cited by 96
Self-citationHydrogen peroxide stimulates rat colonic prostaglandin production and alters electrolyte transport.
Karayalcin, S. S., Sturbaum, C. W., Wachsman, J. T., Cha, J. H., & Powell, D. W. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114715 · Cited by 90
Cited by
Yegutkin, G. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.024 · Cited by 1,154
Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.013 · Cited by 1,030
Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660
Self-citationBerkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 601
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
Stagg, J., Divisekera, U., McLaughlin, N., Sharkey, J., Pommey, S., Denoyer, D., Dwyer, K. M., & Smyth, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908801107 · Cited by 572
Metadata
- Authors
- Madara, J. L., Patapoff, T. W., Gillece-Castro, B., Colgan, S. P., Parkos, C. A., Delp, C., & Mrsny, R. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-05-01
- Volume
- 91
- Issue
- 5
- Pages
- 2320-2325
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2002978565
- Cited by
- 291
- References
- 12
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. https://app.cochat.ai/papers/10.1172/jci116462
- The paper
- Madara, J. L., Patapoff, T. W., Gillece-Castro, B., Colgan, S. P., Parkos, C. A., Delp, C., & Mrsny, R. J. (1993). 5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. Journal of Clinical Investigation. https://doi.org/10.1172/jci116462
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
