The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans
Abstract
Summary: The role of IL-6 as a mediator of haemostatic changes during severe inflammation is controversial. To assess the effect of IL-6 on haemostasis we conducted a controlled cross-over study in eight patients with metastatic renal cell cancer. In all subjects coagulation and fibrinolysis were monitored during and after a 4-h infusion of either 150 μg recombinant human (rh) IL-6, or during infusion of saline (control study). Mean maximum IL-6 concentrations were 1418.0 ± 755.8 pg/ml. Compared to the control study, rhIL-6 induced activation of coagulation as reflected by a 190 ± 55% increase in the plasma levels of thrombin-antithrombin III complexes (p <0.001) and by a 24 ± 11% increase in the plasma levels of in the prothrombin activation fragment F1 + 2 (p <0.001). In contrast, fibrinolysis was not affected. We conclude that in severe inflammation IL-6 may contribute to the activation of coagulation, whereas other factors mediate changes in fibrinolysis.
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Waage, A., Brandtzaeg, P., Halstensen, A., Kierulf, P., & Espevik, T. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.1.333 · Cited by 1,173
van Deventer, S., Buller, H., ten Cate, J., Aarden, L., Hack, C., & Sturk, A. (1990) · Blood · doi:10.1182/blood.v76.12.2520.2520 · Cited by 851
Self-citationC-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
Cermak, J., Key, N., Bach, R., Balla, J., Jacob, H., & Vercellotti, G. (1993) · Blood · doi:10.1182/blood.v82.2.513.513 · Cited by 839
Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects
van der Poll, T., Büller, H. R., ten Cate, H., Wortel, C. H., Bauer, K. A., van Deventer, S. J. H., Hack, C. E., Sauerwein, H. P., Rosenberg, R. D., & ten Cate, J. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006073222302 · Cited by 667
Self-citationSystemic cytokine response after major surgery
Baigrie, R. J., Lamont, P. M., Kwiatkowski, D., Dallman, M. J., & Morris, P. J. (1992) · Journal of British Surgery · doi:10.1002/bjs.1800790813 · Cited by 588
Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.
Creasey, A. A., Chang, A. C., Feigen, L., Wün, T. C., Taylor, F. B., & Hinshaw, L. B. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116529 · Cited by 547
Verheijen, J. H., Mullaart, E., Chang, G. T. G., Kluft, C., & Wijngaards, G. (1982) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657277 · Cited by 475
Le, J., & Vilček, J. (1990) · Pathology Reviews • 1990 · doi:10.1007/978-1-4612-0485-5_7 · Cited by 474
Levi, M., ten Cate, H., Bauer, K. A., van der Poll, T., Edgington, T. S., Büller, H. R., van Deventer, S. J., Hack, C. E., ten Cate, J. W., & Rosenberg, R. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116934 · Cited by 406
Self-citationvan der Poll, T., Levi, M., Hack, C. E., ten Cate, H., van Deventer, S. J., Eerenberg, A. J., de Groot, E. R., Jansen, J., Gallati, H., & Büller, H. R. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1253 · Cited by 383
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Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Acute hyperglycemia and the innate immune system: Clinical, cellular, and molecular aspects
Turina, M., Fry, D. E., & Polk, H. C. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000170106.61978.d8 · Cited by 490
Physical activity and modulation of systemic low-level inflammation
Bruunsgaard, H. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0505247 · Cited by 429
Inflammation and Coagulation in Inflammatory Bowel Disease: The Clot Thickens
Danese, S., Papa, A., Saibeni, S., Repici, A., Malesci, A., & Vecchi, M. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00943.x · Cited by 384
CYTOKINES AND ANTICYTOKINES IN THE PATHOGENESIS OF SEPSIS
van der Poll, T., & van Deventer, S. J. H. (1999) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70083-0 · Cited by 323
Metadata
- Authors
- Stouthard, J. M. L., Levi, M., Hack, C. E., Veenhof, C. H. N., Romijn, H. A., Sauerwein, H. P., & Poll, T. V. D.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1996
- Volume
- 76
- Issue
- 05
- Pages
- 738-742
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W191300012
- Cited by
- 279
- References
- 23
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans. https://app.cochat.ai/papers/10.1055/s-0038-1650653
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- Stouthard, J. M. L., Levi, M., Hack, C. E., Veenhof, C. H. N., Romijn, H. A., Sauerwein, H. P., & Poll, T. V. D. (1996). Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1650653
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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