Cited by 425Pancreatic function and diabetesDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

Open access

De Vos, A, Heimberg, H, Quartier, E, Huypens, P, Bouwens, L, Pipeleers, D, Schuit, F·1995·Journal of Clinical Investigation

DOI 10.1172/jci118308PMC PMC185903

Open this paper in CoChat — free account

Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci118308

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Functional specialization of different hepatocyte populations
Jungermann, K. A., & Katz, N. R. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.3.708 · Cited by 655
Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes
Matschinsky, F. M. (1990) · Diabetes · doi:10.2337/diab.39.6.647 · Cited by 636
STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells
Schnedl, W. J., Ferber, S., Johnson, J. H., & Newgard, C. B. (1994) · Diabetes · doi:10.2337/diab.43.11.1326 · Cited by 483
Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.
Eizirik, D. L., Korbutt, G. S., & Hellerström, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115989 · Cited by 313
Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms
Gould, G. W., THOMAS, H. M., Jess, T. J., & Bell, G. I. (1991) · Biochemistry · doi:10.1021/bi00235a004 · Cited by 303
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.
Matschinsky, F. M., Liang, Y. T., Kesavan, P., Wang, L., Froguel, P., Velho, G., Cohen, D., Permutt, M. A., Tanizawa, Y., & Jetton, T. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116809 · Cited by 287
Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells
Unger, R. H. (1991) · Science · doi:10.1126/science.2006409 · Cited by 263
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
Eizirik, D. L., PIPELEERS, D. G., Ling, Z., Welsh, N., Hellerström, C., & Andersson, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9253 · Cited by 261
Self-citation
The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.
Johnson, J. H., Newgard, C. B., Milburn, J. L., Lodish, H. F., & Thorens, B. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39181-1 · Cited by 207
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young
Velho, G. (1992) · The Lancet · doi:10.1016/0140-6736(92)91768-4 · Cited by 202

Flagged first, then by citations

Show all 40 references

Research works printed but not linked: 2

[9]9. Efrat, S., M. Leiser, Y. J. Wu, D. Fusco-DeMane, O. A. Emran, M. Surana, T. L. Jetton, M. A. Magnuson, G. Weir, and N. Fleischer. 1994. Ribozymemudao ss suss ss eunc mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci. USA. 91:2051–2055.
[17]17. Pipeleers, D. 1994. Treatment of diabetes by islet cell transplantation. In Biomedical and Health Research. Vol. 3, Advances in Medical Biology. C. Baya, editor. IOS Press, Amsterdam. 185–197.

Sorted by citations

Items 301–400 of 423

Involvement of Calcium and Vitamin C in Type 2 Diabetes
Shukla, A. (2012) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-0210920 · Cited by 4
Molecular Aspects of Glucose Regulation of Pancreatic β Cells
Gasa, R., Gomis, R., Novials, A., & Servitja, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00013-0 · Cited by 4
The Metabolic Basis of Insulin Secretion
Doliba, N. M., & Matschinsky, F. M. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-310-1_6 · Cited by 4
[Transcription factors in the adult beta cell].
Lazo-de-la-Vega-Monroy, M.-L., & Fernández‐Mejía, C. (2009) · PubMed · Cited by 4
A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal DiabetesPreprint
Zhou, Z., Gong, M., Pande, A., Lisewski, U., Roepke, T. K., Purfürst, B., Liang, L., Jia, S., Frühler, S., Margineanu, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.24.457485 · Cited by 4
In vivo Anti-Diabetic Studies of Sulfonylurea-Sulfonamide Hybrids
Ahmad, T., Mehmood, T., Shahid, M. M., Ahmad, A., Basra, M. A. R., Zia‐ur‐Rahman, M., & Munawar, M. A. (2019) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/20190614140636 · Cited by 3
Regulation of Insulin Secretion and Islet Cell Function
Weir, G., Bonner-Weir, S., & Sharma, A. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1028-7_1 · Cited by 4
Comparative genomics: beyond the horizon of the next research grant
Schuit, F. C. (2015) · Diabetologia · doi:10.1007/s00125-015-3620-x · Cited by 3
Self-citation
Small Molecule Modulation of GLUT1-Mediated Glucose Transport
Ojelabi, O. (2017) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m2r69f · Cited by 3
Type 2 diabetes: gluco-lipo-toxicity and pancreatic β-cell dysfunction
Roche, E. (2003) · Cited by 3
Islet Function and Insulin Secretion
Jones, P. M., & Persaud, S. J. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch7 · Cited by 3
Insulin-Secreting Cell Lines
Persaud, S. J., Hauge-Evans, A. C., & Jones, P. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408134-5.00015-9 · Cited by 11
Strategies for optimization of hypoglycemia rat models
Zher, L. Y., Kong, E. Q. Z., Raymond, R. E., Jie, Y. Z., & Yap, C. G. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70045 · Cited by 3
SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells
Domingo, J. S., Lassueur, S., Galindo, A. N., Álvarez-Illera, P., Romero-Sanz, S., Caldero-Escudero, E., de la Fuente, S., Dayon, L., & Wiederkehr, A. (2023) · Journal of Cell Science · doi:10.1242/jcs.260049 · Cited by 3
Targets for pollutants in rat and human pancreatic beta-cells: The effect of prolonged exposure to sub-lethal concentrations of hexachlorocyclohexane isomers on the expression of function- and survival-related proteins
Pavlíková, N., Šrámek, J., Jaček, M., Kovár̆, J., & Němcová‐Fürstová, V. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104299 · Cited by 2
Normal Pancreatic Development
Henley, K. D., & Gannon, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.04901-7 · Cited by 1
D-Glucose Combined Chronic Toxicity and Carcinogenicity Studdjs in Sprague-Dawley Rats and Syrian Golden Hamsters
Bomhard, E. M., Bischoff, H., Mager, H., Krötlinger, F., & Schilde, B. (1998) · Drug and Chemical Toxicology · doi:10.3109/01480549809002209 · Cited by 2
Pathophysiology of Glut2 in Diabetes Mellitus
Thorens, B. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1669-9_20 · Cited by 2
Contributions of Mitochondrial Dysfunction to β Cell Failure in Diabetes Mellitus
Parnis, J., & Rutter, G. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00009-2 · Cited by 2
Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture
Suwitheechon, O.-U., & Schermerhorn, T. (2021) · American Journal of Veterinary Research · doi:10.2460/ajvr.82.2.110 · Cited by 2
Regulation of insulin signaling and its developmental and functional roles on peptidergic neurons in the Drosophila central nervous system
Luo, J. (2013) · DiVA (Stockholm University) · Cited by 2
Drug delivery in the anterior chamber of the eye for islet transplantation as a diabetic treatment
Fan, Y. (2018) · doi:10.32657/10356/75793 · Cited by 2
High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cellsPreprint
Cuozzo, F., Viloria, K., Shilleh, A. H., Nasteska, D., Frazer-Morris, C., Jiao, Z., Boufersaoui, A., Marzullo, B. P., Smith, H., Bonner, C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.21.521364 · Cited by 2
Les transporteurs d'hexoses chez l'homme: leur rôle dans l'insulinosensibilité des tissus périphériques
Bastard, J., Jardel, C., Guerre-Millo, M., & Hainque, B. (1998) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(97)83420-0 · Cited by 1
Alloxan☆
Furman, B. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.98061-9 · Cited by 1
Genetically Programmed Defects in β-Cell Function
Pal, A., & Gloyn, A. L. (2011) · Springer eBooks · doi:10.1007/978-1-4419-6956-9_13 · Cited by 1
Rhythms in the Digestive System
Rhoads, D. B., Levitsky, L. L., & Tavakkoli, A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3450-8_10 · Cited by 1
Enhanced Insulin Production From Porcine Islets: More Insulin, Less Islets
Mourad, N. I., & Gianello, P. (2024) · Transplant International · doi:10.3389/ti.2024.13954 · Cited by 1
Apoptosis in Pancreatic β-Islet Cells in Type 1 and Type 2 Diabetes
Tomita, T. (2013) · Springer eBooks · doi:10.1007/978-94-007-6884-0_45-1 · Cited by 1
β‐Cell Biology of Insulin Secretion
Wollheim, C. B., & Maechler, P. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0204 · Cited by 1
Signal Recognition
SCHAFTINGEN, E. V., & Schuit, F. C. (1999) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60094-6 · Cited by 1
Self-citation
In vivo imaging of islet cells and islet revascularization
Nyqvist, D. (2007) · Figshare · Cited by 1
Terapia gênica para o diabetes
Demeterco, C., & Levine, F. (2001) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302001000100013 · Cited by 1
The role of CADM1 in energy and glucose homeostasis
Matthäus, D. (2014) · doi:10.18452/16905 · Cited by 1
Hypoglycemia
Hussain, K., & Dunne, M. J. (2005) · Clinical Pediatric Endocrinology · doi:10.1002/9780470987117.ch22 · Cited by 1
Glycemic Control of Apoptosis in the Pancreatic Beta Cell: Danger of Extremes?
Martens, G. A., & de Casteele, M. V. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.ft-16 · Cited by 1
Glucose transport in brain and retina: implications in the management and complications of diabetes
Kumagai, A. K. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199907/08)15:4 · Cited by 159
Examining the Effect of Maternal High-Fat Diet Consumption on the Physiology and Pancreas Development of Fetal and Juvenile Nonhuman Primate Offspring
Comstock, S. M. (2000) · doi:10.15760/etd.551
Studies Of Regulated Exocytosis From Neuroendocrine Cells
Das, D. M. (2013) · Human Biology
Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase
Harach, T. (2010) · edoc (University of Basel) · doi:10.5451/unibas-005405424
Molecular mechanisms regulating exocytosis : Studies of insulin secretion and neurotransmitter release
Lilja, L. (2005) · Figshare
Insulin Secretion and Actions
Jitrapakdee, S., & Briony, E. (2011) · InTech eBooks · doi:10.5772/21631
Cyclic AMP oscillations in insulin-secreting cells
Sågetorp, J. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Diabetes tipo 2: gluco-lipo-toxicidad y disfunciÓn de la célula β pancreática
Roche, E. (2003) · Institutional Repository of the University of Granada (University of Granada) · doi:10.30827/ars.v44i4.5671 · Cited by 3
Long-chain fatty acids and endoplasmic reticulum stress in pancreatic beta-cells: the role of Protein Kinase R (PKR)
Cooper, A. W. J. (2013) · PEARL (University of Plymouth) · doi:10.24382/4356
Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices
Speier, S. (2004) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-531
Pulsatile insulin release from single islets of Langerhans
Westerlund, J. (2000) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Cell Cycle Regulation in Human Pancreatic Beta Cells
Fiaschi‐Taesch, N., Harb, G., Karsiloglu, E., Takane, K. K., & Stewart, A. F. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-366-4_3
Diabetogenic effects of Glucocorticoids : role of Protein Phosphatase 5 and GLP-1 receptor activation
Fransson, L. (2014) · Figshare
Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
Heimann, E. (2014) · Lund University Publications (Lund University)
Protein expression analysis of Insulin producing cells exposed to endoplasmic reticulum stress
Rosengren, V. (2015) · Figshare
Aspects on the modulation of potassium channels in insulin-producing beta-cells
Ma, Z. (2006) · Figshare
revisão Terapia Gênica para o Diabetes
Demeterco, C., & Levine, F. (2001)
Mitochondrial Factors in the Pathogenesis of Diabetes: A Hypothesis for Treatment Davis W. Lamson, MS, ND,
Plaza, S. M. (2002)
MicroRNA and Diabetes Mellitus
Salö, S., Geiger, J., Sørensen, A. E., & Dalgaard, L. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00021-x
On Glucose Metabolism in Patients with the m.3243A>G Mutation
Lindroos, M. M. (2013) · UTUPub (University of Turku)
Cell coupling and exocytosis measured in intact pancreatic islets Control of δ -cell somatostatin secretion
Zhang, Q. (2008)
Investigation of promoter histone deacetylation as a mechanism for cyclic adenosine monophospate-stimulated repression of microRNA-375
Stanton, A. R. (2015) · California State University ScholarWorks (system-wide DSpace)
The pro-survival effects of glucose-dependent insulinotropic polypeptide receptor signalling on beta cells
Widenmaier, S. B. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0071070
CFTR in pancreatic islets
Edlund, A. (2016) · Lund University Publications (Lund University)
4. New Insights of Islet Biology and the Pathophysiology of Type 2 Diabetes
Powers, A. C., & Stein, R. W. (2011) · Translational endocrinology & metabolism · doi:10.1210/team.9781879225824.ch4
Pancreatic B -Cell, a Unique Fuel Sensor
Komatsu, M. (2005) · Oxidative stress and disease · doi:10.1201/9781420028362.pt3
Preclinical Safety Assessment of Drug Candidate‐Induced Pancreatic Toxicity
Brenneman, K. A., Ramaiah, S. K., & Gauthier, L. M. (2016) · doi:10.1002/9781119053248.ch17
Cellular Immunological Mechanisms Contributing to Diabetes Pathogenesis
Radenkovic, M. (2016) · Lund University Publications (Lund University)
Regulation of endoplasmic reticulum calcium homeostasis in pancreatic β cells
Tong, X. (2016) · IUScholarWorks (Indiana University) · doi:10.7912/c2ms4g
Studies relating to the differentiation of human embryonic stem cells
Anyfantis, G. (2015) · Research Explorer (The University of Manchester)
Molecular mechanisms of glucose-sensing shared by insulin-secreting cells and glucose-sensing neurons of the rat hypothalamus
Tompkins, L. S. (2000) · UA Campus Repository (The University of Arizona)
Insights into the metabolic regulation of insulin secretion using a metabolomics approach
Huang, M. (2014) · UWSpace (University of Waterloo)
Investigating the Attenuation of Starch Hydrolysis by Synergistic Interaction of Xanthan and Guar Gum Fortification during In Vitro Digestion
Aylward, D. (2018) · The Atrium (University of Guelph)
A Study to Correlate Serum Magnesium, Serum Calcium, HbA1c and Nerve Conduction Parameters in Type 2 Diabetes Mellitus
Vaiz, P. (2017)
Nicotinamide Mononucleotide in the Context of Elevated Plasma Levels of Free Fatty Acids Improves Glucose Tolerance by Decreasing Insulin Clearance
Nahle, A. (2016) · TSpace (University of Toronto)
Novel mechanisms of glucolipotoxic pancreatic beta cell death
Hanna, K. (2018) · Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)
Mecanismos moleculares mediadores da citoproteção de células beta pancreáticas induzidos por prolactina
Mansano, R. A. W. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2019.tde-07052019-111824
Role of insulin-degrading enzyme (IDE) in pancreatic beta-cell function: relevance in health and diabetes mellitus
Díaz, C. M. F. (2019) · doi:10.35376/10324/39208
The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excessPreprint
Nasteska, D., Cuozzo, F., Thakker, A., Bakar, R. B., Westbrook, R. L., Akerman, I., Cantley, J., Tennant, D., & Hodson, D. (2020) · bioRxiv · doi:10.1101/2020.04.30.068106
12-lipoxygenase Promotes Macrophage Infiltration and Pancreatic Islet Dysfunction in the Vertebrate Models of Diabetes Pathogenesis
Kulkarni, A. (2020) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1921
Apoptosis in Pancreatic β-Cells in Type 1 and Type 2 Diabetes
Tomita, T. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_45
Apoptosis in Pancreatic b-Cells in Type 1 and Type 2 Diabetes 31
Tomita, T. (2015)
Biosynthesis, intracellular-trafficking, and exocytosis of insulin granules
Gupta, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820234-0.00006-8
O papel da desnutrição proteica e do exercício físico crônico na modulação mitocondrial da secreção de insulina
Leite, N. C. (2016) · doi:10.47749/t/unicamp.2016.979137
Função da interleucina-6 (IL-6) sobre a modulação da "insulin-degrading enzyme" (IDE) durante o exercício físico agudo
Kurauti, M. A. (2017) · doi:10.47749/t/unicamp.2017.985452
Pancreatic development and maturation of the islet B cell
Madsen, O. D., Jensen, J. N., Blume, N., Petersen, H. V., Lund, K., Karlsen, C., Andersen, F. G., Jensen, P. B., Larsson, L., & Serup, P. (1996) · Springer eBooks · doi:10.1007/978-3-642-60659-5_16
Islet Regeneration
Xu, X., D’Hoker, J., Leu, N. D., Xiao, X., Heremans, Y., de Casteele, M. V., & Heimberg, H. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-366-4_4
Self-citation
GLUT2 or not GLUT2? That is the question
Available, N. A. N. (1997) · Diabetologia · doi:10.1007/s001250050650
Experimental studies aiming to prevent type 1 diabetes mellitus.
Rydgren, T. (2007) · Uppsala University Publications (Uppsala University)
3 Glycolyse
Schuit, F. C. (2010) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-8225-5_3
Self-citation
Glycolyse
Schuit, F. C. (2015) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-0620-6_3
Self-citation
Alloxan
Furman, B. L. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.61187-0
Glycolyse
Schuit, F. C. (2019) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2358-6_3
Self-citation
اكتشاف جين جديد يساهم في الإصابة بمرض السكري ويؤثر في استقلاب الغلوكوز
تنيرة, ج., الرفاعي, ل., & محمد, ع. ا. (2022) · Arabian Journal of Scientific Research-المجلة العربية للبحث العلمي · doi:10.5339/ajsr.2022.2
Efeitos da ingestão dos sucos de laranja das variedades Pera e Moro sobre o proteoma de camundongos submetidos à dieta hiperlipídica e suplementada com leite condensado
Siqueira, M. D. S. B. (2022) · doi:10.11606/t.9.2022.tde-01122022-182940
A New Gene Contributes to Diabetes and Affects Glucose Metabolism
(2023) · International Journal of Clinical & Experimental Dermatology · doi:10.33140/ijced.08.02.06
Insulin Secretion and the β-Cell 102 Years After the Discovery of the Hormone
Ortis, F., Rebelato, E., Carpinelli, Â. R., & Abdulkader, F. (2024) · Current Molecular Biology Reports · doi:10.1007/s40610-024-00158-9
Minimal SC-β-Cell Properties for Transplantation in Diabetic Patients
Cochrane, V. A., Xiao, Y., Maachi, H., & Hebrok, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_22
An INS-1 β-cell proteome highlights the role of fatty acid biosynthesis in glucose-stimulated insulin secretionPreprint
Stremmel, N., Lemke, O., Textoris‐Taube, K., Ludwig, D., Mülleder, M., Muenzner, J., & Ralser, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.12.603204
Computational Study on the Viability of Encapsulated Pancreatic Islets for Type 1 Diabetes
Félix‐Martínez, G. J., Osorio-Londoño, D., & Godínez-Fernández, J. R. (2025) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-031-89514-2_11
Presenilin-1 controls glucose metabolism and identity of pancreatic beta cellsPreprint
Koshenov, Z., Postić, S., Schosiwohl, G., van Amsterdam, S., Hois, V., Oflaz, F. E., Rost, R., Tiapko, O., Gottschalk, B., Hirtl, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.05.674426
Fructose and insulin: A sweet sabotage hypothesis?
Özer, N., Dalmızrak, Ö., Elabiad, S., & Öğüş, İ. H. (2025) · Endocrine · doi:10.1007/s12020-025-04464-9 · Cited by 2
Substrate Control of Insulin Release
Newgard, C. B., & Matschinsky, F. M. (2001) · Comprehensive physiology · doi:10.1002/j.2040-4603.2001.tb01451.x
Extracellular Matrix-Guided Islet Cell Transplantation Results in Improved Glycemic Control in a NOD-SCID Mouse Model
Korol, R., Even‐Ram, S., Molakandov, K., Puchinsky, D., Hemed, M., Mizrahi, N., Toledo, I., Lazar, D., Chebath, J., Tritel, M., et al. (2025) · Hormone and Metabolic Research · doi:10.1055/a-2734-1983

Authors: De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., & Schuit, F.
ORCID: Heimberg, H
Quartier, E
Huypens, P
Bouwens, L
Pipeleers, D
Schuit, F
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1995-11-01
Volume: 96
Issue: 5
Pages: 2489-2495
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118308
PMC: PMC185903
OpenAlex: W2015001567
Cited by: 425
References: 40
Citations by year: 2026: 3 · 2025: 13 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 23 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 27 · 2015: 21 · 2014: 23 · 2013: 23 · 2012: 21
FWCI: 11.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Eli Lilly and Company
Universitaire Stichting
Université de Genève
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: pancreatic beta cells, GLUT2, GLUT1, glucokinase, glucose transporter gene expression, glucose detection, glucose homeostasis, alloxan, glucose phosphorylation, diabetes mellitus
MeSH terms: Animals, Cells, Cultured, Glucokinase, Glucose, Humans, Islets of Langerhans, Monosaccharide Transport Proteins, Phosphorylation, Gene Expression, Glucose Transporter Type 1, Glucose Transporter Type 2, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks