CoChat
Sign Up
Cited by 425Pancreatic function and diabetesDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

Open access
De Vos, A, Heimberg, H, Quartier, E, Huypens, P, Bouwens, L, Pipeleers, D, Schuit, F·1995·Journal of Clinical Investigation
DOI 10.1172/jci118308PMC PMC185903
Open this paper in CoChat — free account

Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci118308

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 40 references

Research works printed but not linked: 2

  1. [9]9. Efrat, S., M. Leiser, Y. J. Wu, D. Fusco-DeMane, O. A. Emran, M. Surana, T. L. Jetton, M. A. Magnuson, G. Weir, and N. Fleischer. 1994. Ribozymemudao ss suss ss eunc mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci. USA. 91:2051–2055.
  2. [17]17. Pipeleers, D. 1994. Treatment of diabetes by islet cell transplantation. In Biomedical and Health Research. Vol. 3, Advances in Medical Biology. C. Baya, editor. IOS Press, Amsterdam. 185–197.

Cited by

Sorted by citations

Items 401–423 of 423

Related

See all

Metadata

Authors
De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., & Schuit, F.
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1995-11-01
Volume
96
Issue
5
Pages
2489-2495
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci118308
PMC
PMC185903
OpenAlex
W2015001567
Cited by
425
References
40
Citations by year
2026: 3 · 2025: 13 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 23 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 27 · 2015: 21 · 2014: 23 · 2013: 23 · 2012: 21
FWCI
11.19
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Eli Lilly and Company
  • Universitaire Stichting
  • Université de Genève
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
pancreatic beta cells, GLUT2, GLUT1, glucokinase, glucose transporter gene expression, glucose detection, glucose homeostasis, alloxan, glucose phosphorylation, diabetes mellitus
MeSH terms
Animals, Cells, Cultured, Glucokinase, Glucose, Humans, Islets of Langerhans, Monosaccharide Transport Proteins, Phosphorylation, Gene Expression, Glucose Transporter Type 1, Glucose Transporter Type 2, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review