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Cited by 462

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.

Open access
Panina-Bordignon, P, Mazzeo, D, Lucia, P D, D'Ambrosio, D, Lang, R, Fabbri, L, Self, C, Sinigaglia, F·1997·Journal of Clinical Investigation
DOI 10.1172/jci119674
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Abstract

Interleukin 12 (IL-12) plays a central role in the immune system by skewing the immune response towards T helper 1 (Th1) type responses which are characterized by high interferon-gamma and low IL-4 production. In this report we present evidence that beta2-agonists inhibit IL-12 production by both human monocytes in response to lipopolysaccharide (LPS) and dendritic cells stimulated via CD40. Inhibition of IL-12 production is selective, as other cytokines produced by monocytes are unaffected. IL-12 inhibition is dependent on beta2-adrenoceptor stimulation and correlates with increased levels of intracellular cAMP. In conjunction with their ability to suppress IL-12 production, when beta2-agonists are added at priming of neonatal T lymphocytes, they inhibit the development of Th1-type cells, while promoting T helper 2 (Th2) cell differentiation. Further, the in vivo administration of a therapeutic dose of salbutamol results in the selective inhibition of IL-12 production by whole blood lymphocytes stimulated in vitro with LPS. These findings provide new insight into the immunological consequences of the clinical use of beta2-agonists and may suggest new approaches for the treatment of Th1-mediated diseases.

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Metadata

Authors
Panina-Bordignon, P., Mazzeo, D., Lucia, P. D., D'Ambrosio, D., Lang, R., Fabbri, L., Self, C., & Sinigaglia, F.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1997-09-15
Volume
100
Issue
6
Pages
1513-1519
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci119674
OpenAlex
W2067989244
Cited by
462
References
35
FWCI
10.70
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. https://app.cochat.ai/papers/10.1172/jci119674
The paper
Panina-Bordignon, P., Mazzeo, D., Lucia, P. D., D'Ambrosio, D., Lang, R., Fabbri, L., Self, C., & Sinigaglia, F. (1997). Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. Journal of Clinical Investigation. https://doi.org/10.1172/jci119674

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.