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Cited by 611

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Why there are two cyclooxygenase isozymes

Open access
Smith, William L., Langenbach, Robert·2001·Journal of Clinical Investigation
DOI 10.1172/jci13271
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Abstract

Prostaglandins and their precursorsPhysiological processes for which PGHS-2 is responsible Ovulation and implantation.PGHS-2-null female mice are infertile (3).Although follicular development is observed in PGHS-2-deficient mice, ovulation is greatly reduced and, of the eggs released, very few are fertilized (8).Ovarian PGE 2 production is increased by pituitary gonadotropins in wild-type and PGHS-1-null mice, but not in PGHS-2-null mice, indicating that PGHS-2 is responsible for this increased ovarian PGE 2 production.Because ovulation in PGHS-2-null mice can be restored by PGE 2 administration (11), PGE 2 formed via PGHS-2 is believed to be the product that is responsible for ovulation.In addition to affecting ovu-Why there are two cyclooxygenase isozymes

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Cites

Show all 4 references

Research works printed but not linked: 34

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Metadata

Authors
Smith, W. L., & Langenbach, R.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2001-06-15
Volume
107
Issue
12
Pages
1491-1495
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci13271
OpenAlex
W2125376440
Cited by
611
References
4
FWCI
28.35
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Why there are two cyclooxygenase isozymes. https://app.cochat.ai/papers/10.1172/jci13271
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Smith, W. L., & Langenbach, R. (2001). Why there are two cyclooxygenase isozymes. Journal of Clinical Investigation. https://doi.org/10.1172/jci13271

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.