Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
Open accessAbstract
Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed, several skeletal diseases, such as bone fracture, osteonecrosis, and inflammation are characterized by excessive osteocyte death. Herein we show that osteoclasts sense damage-associated molecular patterns (DAMPs) released by necrotic osteocytes via macrophage-inducible C-type lectin (Mincle), which induced their differentiation and triggered bone loss. Osteoclasts showed robust Mincle expression upon exposure to necrotic osteocytes in vitro and in vivo. RNA sequencing and metabolic analyses demonstrated that Mincle activation triggers osteoclastogenesis via ITAM-based calcium signaling pathways, skewing osteoclast metabolism toward oxidative phosphorylation. Deletion of Mincle in vivo effectively blocked the activation of osteoclasts after induction of osteocyte death, improved fracture repair, and attenuated inflammation-mediated bone loss. Furthermore, in patients with osteonecrosis, Mincle was highly expressed at skeletal sites of osteocyte death and correlated with strong osteoclastic activity. Taken together, these data point to what we believe is a novel DAMP-mediated process that allows osteoclast activation and bone loss in the context of osteocyte death.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DAMPs can directly regulate osteoclast formation by activating the membrane-bound C-type lectin receptor Mincle; Mincle activation triggers calcium signaling and oxidative phosphorylation in osteoclasts, inducing osteoclast differentiation.
“DAMPs can directly regulate osteoclast formation by activating the membrane-bound C-type lectin receptor Mincle. Mincle activation triggers calcium signaling and oxidative phosphorylation in osteoclasts, inducing osteoclast differentiation.74”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [74]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 2× · see citing works
“This rather well-understood process is orchestrated by blood-derived monocytes that differentiate into bone-resorbing osteoclasts (1).”
BackgroundCirculating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works
Fracture healing: mechanisms and interventions
Einhorn, T. A., & Gerstenfeld, L. C. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.164 · Cited by 1,832 · see citing works
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778 · see citing works
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. (2003) · Nature reviews genetics · doi:10.1038/nrg1122 · Cited by 1,733 · see citing works
The ovariectomized rat model of postmenopausal bone loss
Kalu, D. N. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90124-i · Cited by 1,364 · see citing works
Matrix-embedded cells control osteoclast formation
Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304 · see citing works
Damage-associated molecular patterns in inflammatory diseases
Roh, J. S., & Sohn, D. H. (2018) · Immune Network · doi:10.4110/in.2018.18.e27 · Cited by 1,261 · see citing works
Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · cited 1× · see citing works
“Dentin matrix protein 1 (DMP1) is almost exclusively expressed in mature osteocytes (26, 27).”
BackgroundA Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
Buch, T., Heppner, F. L., Tertilt, C., Heinen, T. J. A. J., Kremer, M., Wunderlich, F. T., Jung, S., & Waisman, A. (2005) · Nature Methods · doi:10.1038/nmeth762 · Cited by 922 · see citing works
Necrotic death as a cell fatePreprint
Zong, W., & Thompson, C. B. (2006) · Genes & Development · doi:10.1101/gad.1376506 · Cited by 912 · see citing works
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848 · see citing works
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Ishikawa, E., Ishikawa, T., Morita, Y. S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., & Yamasaki, S. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091750 · Cited by 794 · see citing works
Mincle is an ITAM-coupled activating receptor that senses damaged cells
Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K., & Saito, T. (2008) · Nature Immunology · doi:10.1038/ni.1651 · Cited by 740 · see citing works
Verborgt, O., Gibson, G. J., & Schaffler, M. B. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.60 · Cited by 731 · see citing works
From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins
Korganow, A., Ji, H., Mangialaio, S., Duchatelle, V., Pelanda, R., Martin, T., Degott, C., Kikutani, H., Rajewsky, K., Pasquali, J., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80045-x · Cited by 691 · see citing works
The role of estrogen and androgen receptors in bone health and disease
Manolagas, S. C., O’Brien, C. A., & Almeida, M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.179 · Cited by 579 · see citing works
Current concepts on osteonecrosis of the femoral head
Moya-Angeler, J. (2015) · World Journal of Orthopedics · doi:10.5312/wjo.v6.i8.590 · Cited by 548 · see citing works
Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E. M., Stenger, S., Andersen, P. L., Ruland, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904013 · Cited by 493 · see citing works
Self-citationWells, C. A., Salvage-Jones, J., Li, X., Hitchens, K., Butcher, S., Murray, R. Z., Beckhouse, A. G., Lo, Y.-L.-S., Manzanero, S., Cobbold, C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7404 · Cited by 434 · see citing works
The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone
Tomkinson, A., REEVE, J., Shaw, R. W., & Noble, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4200 · Cited by 417 · see citing works
Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation
Ishii, K.-A., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., et al. (2009) · Nature Medicine · doi:10.1038/nm.1910 · Cited by 410 · see citing works
Apoptosis of Osteocytes in Glucocorticoid-Induced Osteonecrosis of the Hip 1
Weinstein, R. S., Nicholas, R. W., & Manolagas, S. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6714 · Cited by 397 · see citing works
Mechanisms of Disease: a 'DAMP' view of inflammatory arthritis
Foell, D., Wittkowski, H., & Roth, J. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0531 · Cited by 350 · see citing works
DMP1-targeted Cre Expression in Odontoblasts and Osteocytes
Lu, Y., Xie, Y., Zhang, S., Dusevich, V., Bonewald, L. F., & Feng, J. Q. (2007) · Journal of Dental Research · doi:10.1177/154405910708600404 · Cited by 350 · see citing works
Grüneboom, A., Hasenberg, A., Ludwig‐Portugall, I., Medyukhina, A., Männ, L., Brenzel, A., Engel, D. R., Figge, M. T., Kurts, C., & Gunzer, M. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016020232 · Cited by 348 · see citing works
Self-citationAppel, H., Ruiz‐Heiland, G., Listing, J., Zwerina, J., i, M. H., Müeller, R. B., Haibel, H., Baraliakos, X., Hempfing, A., Rudwaleit, M., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24888 · Cited by 326 · see citing works
Self-citationApoptosis of Osteocytes in Glucocorticoid-Induced Osteonecrosis of the Hip
Weinstein, R. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2907 · Cited by 315 · see citing works
A network of trans-cortical capillaries as mainstay for blood circulation in long bones
Grüneboom, A., Hawwari, I., Weidner, D., Culemann, S., Müller, S., Henneberg, S., Brenzel, A., Merz, S. F., Bornemann, L., Zec, K., et al. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0016-5 · Cited by 308 · see citing works
Self-citationJin, Z., Wei, W., Yang, M., Du, Y., & Wan, Y. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.011 · Cited by 283 · see citing works
Woo, S. M., Rosser, J., Dusevich, V., Kalajzic, I., & Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.465 · Cited by 243 · see citing works
Osteocyte apoptosis and control of bone resorption following ovariectomy in mice
Emerton, K. B., Hu, B., Woo, A. A., Sinofsky, A., Hernandez, C., Majeska, R. J., Jepsen, K. J., & Schaffler, M. B. (2010) · Bone · doi:10.1016/j.bone.2009.11.006 · Cited by 220 · see citing works
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050815 · Cited by 216 · see citing works
Osteocyte function, osteocyte death and bone fracture resistance
Noble, B., & REEVE, J. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00174-4 · Cited by 211 · see citing works
A standardized experimental fracture in the mouse tibia
Hiltunen, A., VUORIO, E. I., & Aro, H. T. (1993) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100110219 · Cited by 208 · see citing works
Jilka, R. L., Noble, B., & Weinstein, R. S. (2012) · Bone · doi:10.1016/j.bone.2012.11.038 · Cited by 202 · see citing works
Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
Komori, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122045 · Cited by 176 · cited 2× · see citing works
“However, because phagocytes cannot reach and engulf apoptotic osteocytes in their isolated lacunae, these cells automatically undergo secondary necrosis, losing their membrane integrity and releasing damage-associated molecular patterns (DAMPs) into their environment (10).”
BackgroundBisphosphonates Cause Osteonecrosis of the Jaw-Like Disease in Mice
Bi, Y., Gao, Y., Ehirchiou, D., Cao, C., Kikuiri, T., Lê, A., Shi, S., & Zhang, L. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090592 · Cited by 174 · see citing works
Nagata, M., Izumi, Y., Ishikawa, E., Kiyotake, R., Doi, R., Iwai, S., Omahdi, Z., Yamaji, T., Miyamoto, T., Bamba, T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618133114 · Cited by 172 · see citing works
Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging
Hayashi, M., Nakashima, T., Yoshimura, N., Okamoto, K., Tanaka, S., & Takayanagi, H. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.021 · Cited by 156 · see citing works
Th2 and eosinophil responses suppress inflammatory arthritis
Zhu, C., Andreev, D., Oeser, K., Krljanac, B., Hueber, A. J., Kleyer, A., Voehringer, D., Schett, G. A., & Bözec, A. (2016) · Nature Communications · doi:10.1038/ncomms11596 · Cited by 151 · see citing works
Self-citationNatural History of Osteonecrosis of the Jaw in Patients With Multiple Myeloma
Badros, A. Z., Terpos, E., Katodritou, E., Goloubeva, O. G., Kastritis, E., Verrou, E., Zervas, K., Baer, M. R., Meiller, T. F., & Dimopoulos, M. A. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.9300 · Cited by 143 · see citing works
Favia, G., Pilolli, G. P., & Maiorano, E. (2009) · Bone · doi:10.1016/j.bone.2009.05.008 · Cited by 138 · see citing works
C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity
Drouin, M., Coronilla, J. S., & Chiffoleau, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00251 · Cited by 133 · see citing works
Tmem64 Modulates Calcium Signaling during RANKL-Mediated Osteoclast Differentiation
Kim, H., Kim, T. S., Jeong, B., Cho, I., Han, D., Takegahara, N., Negishi‐Koga, T., Takayanagi, H., Lee, J. H., Sul, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.002 · Cited by 118 · see citing works
CellTracker (not only) for dummies
Piccinini, F., Kiss, A., & Horváth, P. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv686 · Cited by 115 · see citing works
Filgueira, L. (2004) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540405200312 · Cited by 108 · see citing works
Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
Patin, E. C., Orr, S. J., & Schaible, U. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00861 · Cited by 101 · see citing works
Wang, C., Wang, X., Xu, X., Yuan, X., Gou, W.-L., Wang, A., Guo, Q., Peng, J. C., & Lu, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096361 · Cited by 96 · see citing works
Bedogni, A., Bettini, G., Totola, A., Saia, G., & Nocini, P. F. (2010) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2010.02.037 · Cited by 91 · see citing works
Cheung, W. Y., Fritton, J. C., Morgan, S. A., Seref-Ferlengez, Z., Basta-Pljakic, J., Thi, M. M., Suadicani, S. O., Spray, D. C., Majeska, R. J., & Schaffler, M. B. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2740 · Cited by 89 · see citing works
Wang, C., Meng, H., Wang, Y., Zhao, B., Zhao, C., Sun, W., Zhu, Y., Han, B., Yuan, X., Liu, R., et al. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.18334 · Cited by 85 · see citing works
Zhang, B., Hou, R., Zou, Z., Luo, T., Zhang, Y., Wang, L., & Wang, B. (2017) · Redox Biology · doi:10.1016/j.redox.2017.10.021 · Cited by 76 · see citing works
Wu, Y., Torchia, J. A., Yao, W., Lane, N. E., Lanier, L. L., Nakamura, M. C., & Humphrey, M. B. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000586 · Cited by 73 · see citing works
3Dscript: animating 3D/4D microscopy data using a natural-language-based syntax
Schmid, B., Tripal, P., Fraaß, T., Kersten, C., Ruder, B., Grüneboom, A., Huisken, J., & Palmisano, R. (2019) · Nature Methods · doi:10.1038/s41592-019-0359-1 · Cited by 71 · see citing works
Self-citationMoonlighting osteoclasts as undertakers of apoptotic cells
Steffen, U., Keppeler, H., Ipseiz, N., Derer, A., Poller, K., Aigner, M., Schett, G. A., i, M. H., & Lauber, K. (2012) · Autoimmunity · doi:10.3109/08916934.2012.719950 · Cited by 68 · see citing works
Self-citationGroß, C., Weber, M., Creutzburg, K., Möbius, P., Preidl, R. H. M., Amann, K., & Wehrhan, F. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1230-8 · Cited by 59 · see citing works
Self-citationMincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
Patin, E. C., Willcocks, S., Orr, S. J., Ward, T. H., Lang, R., & Schaible, U. E. (2016) · Innate Immunity · doi:10.1177/1753425916636671 · Cited by 43 · see citing works
Self-citationZimmerman, S. M., Heard‐Lipsmeyer, M. E., Dimori, M., Thostenson, J. D., Mannen, E. M., O’Brien, C. A., & Morello, R. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.06.008 · Cited by 40 · see citing works
Brown, G. D. (2008) · Nature Immunology · doi:10.1038/ni1008-1099 · Cited by 39 · see citing works
Development of a Mouse Model of Ischemic Osteonecrosis
Kamiya, N., Yamaguchi, R., Aruwajoye, O. O., Adapala, N. S., & Kim, H. K. W. (2015) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-015-4172-6 · Cited by 36 · see citing works
Córdova, L. A., Guilbaud, F., Amiaud, J., Battaglia, S., Charrier, C., Lézot, F., Piot, B., Rédiní, F., & Heymann, D. (2016) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2016.07.015 · Cited by 25 · see citing works
Interaction between the immune system and bone metabolism: an emerging field of osteoimmunology
Takayanagi, H. (2007) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.83.136 · Cited by 24 · see citing works
RSK2 protects mice against TNF-induced bone loss
Böhm, C., Derer, A., Axmann, R., Hillienhoff, U., Zaiss, M. M., Luther, J., Zech, C., Stock, M., Scholtysek, C., Engelke, K., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.096008 · Cited by 18 · see citing works
Self-citationZhou, L., Yoon, S., Jang, K. Y., Moon, Y. J., Wagle, S., Lee, K. B., Park, B., & Kim, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110593 · Cited by 17 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mechanical regulation of bone remodeling
Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641 · see citing works
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works
The role of autophagy in bone metabolism and clinical significance
Wang, J., Zhang, Y., Cao, J., Wang, Y., Anwar, N., Zhang, Z., Zhang, D., Ma, Y., Xiao, Y., Xiao, L., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2186112 · Cited by 327 · see citing works
Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
Yang, Y., Lin, Y., Wang, M., Yuan, K., Wang, Q., Mu, P., Du, J., Yu, Z., Yang, S., Huang, K., et al. (2022) · Bone Research · doi:10.1038/s41413-022-00198-w · Cited by 267 · see citing works
Targeting strategies for bone diseases: signaling pathways and clinical studies
Xu, H., Wang, W., Liu, X., Huang, W. H., Chen, Z., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01467-8 · Cited by 173 · see citing works
The effects of microgravity on bone structure and function
Man, J., Graham, T., Squires-Donelly, G., & Laslett, A. L. (2022) · npj Microgravity · doi:10.1038/s41526-022-00194-8 · Cited by 160 · see citing works
Lotus seedpod-inspired internal vascularized 3D printed scaffold for bone tissue repair
Han, X., Sun, M., Chen, B., Saiding, Q., Zhang, J., Song, H., Deng, L., Wang, P., Gong, W., & Cui, W. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.11.019 · Cited by 141 · see citing works
Myeloid C-type lectin receptors in innate immune recognition
Sousa, C. R. E., Yamasaki, S., & Brown, G. D. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.005 · Cited by 130 · see citing works
The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens
Mills, E., Yang, L. Y., Nielsen, M. F., Kassem, M. S., Dhillo, W. S., & Comninos, A. N. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab015 · Cited by 131 · see citing works
Neurophysiological mechanisms of cancer-induced bone pain
Zheng, X.-Q., Wu, Y., Huang, J.-F., & Wu, A. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.06.006 · Cited by 115 · see citing works
Hypertension meets osteoarthritis — revisiting the vascular aetiology hypothesis
Ching, K. Z., Houard, X., Berenbaum, F., & Wen, C. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00650-x · Cited by 109 · see citing works
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis
Jiang, Z., Qi, G., He, X., Yu, Y., Cao, Y., Zhang, C., Zou, W., & Yuan, H. (2024) · Advanced Science · doi:10.1002/advs.202307388 · Cited by 108 · see citing works
Zhang, Y., Li, Y., Lu, P., Dai, G.-C., Chen, X.-X., & Rui, Y. (2021) · Food & Function · doi:10.1039/d0fo03468a · Cited by 88 · see citing works
Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases
Oton, L., Mazziotta, C., Iaquinta, M. R., Mazzoni, E., Nocini, R., Trevisiol, L., D’Agostino, A., Tognon, M. G., Rotondo, J. C., & Martini, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031500 · Cited by 77 · see citing works
Guan, Y., Zhang, W., Mao, Y., & Li, S. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02161-1 · Cited by 85 · see citing works
Zhang, Y., Xie, R., Dai, C.-S., Gao, H., Zhou, G., Qi, T., Wang, W.-Y., Wang, H., & Yi-min, C. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.08.008 · Cited by 77 · see citing works
Masters, E. A., Bentley, K. L. D. M., Gill, A. L., Hao, S. P., Galloway, C. A., Salminen, A. T., Guy, D. R., McGrath, J. L., Awad, H. A., Gill, S. R., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008988 · Cited by 68 · see citing works
Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system
Xin, L., Zhou, F., Zhang, C., Zhong, W., Xu, S., Jing, X., Wang, D., Wang, S., Chen, T., & Song, J. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00177-1 · Cited by 66 · see citing works
Skeletal regeneration for segmental bone loss: Vascularised grafts, analogues and surrogates
Dalisson, B., Charbonnier, B., Aoude, A., Gilardino, M. S., Harvey, E. J., Makhoul, N. M., & Barralet, J. E. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.09.053 · Cited by 64 · see citing works
Zhang, L., Jiao, G., You, Y., Li, X., Liu, J., Sun, Z., Li, Q., Dai, Z., Ma, J., Zhou, H., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1369 · Cited by 61 · see citing works
Aguirre, J. I., Castillo, E. J., & Kimmel, D. B. (2021) · Bone · doi:10.1016/j.bone.2021.116168 · Cited by 60 · see citing works
Innate immune memory in inflammatory arthritis
Jeljeli, M. M., & Adamopoulos, I. E. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01009-0 · Cited by 59 · see citing works
Lu, J., Yu, N., Liu, Q., Xie, Y., & Lei, Z. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s409664 · Cited by 58 · see citing works
The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity
Malamud, M., & Brown, G. D. (2024) · EMBO Reports · doi:10.1038/s44319-024-00296-2 · Cited by 57 · see citing works
Wu, Y., Teng, Y., Zhang, C., Pan, Y. H., Zhang, Q., Zhu, X. H., Liu, N., Su, X., & Lin, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01320-0 · Cited by 56 · see citing works
Wei, F., Ruan, B., Dong, J. P., Yang, B., Zhang, G., Yeung, W. K. K., Wang, H., Cao, W., & Wang, Y. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.11.036 · Cited by 53 · see citing works
The osteocyte and its osteoclastogenic potential
Marahleh, A., Kitaura, H., Ohori, F., Noguchi, T., & Mizoguchi, I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1121727 · Cited by 53 · see citing works
Occlusal Force Maintains Alveolar Bone Homeostasis via Type H Angiogenesis
Chen, Y., Yin, Y., Luo, M., Wu, J., Chen, A., Deng, L., Xie, L., & Han, X. (2023) · Journal of Dental Research · doi:10.1177/00220345231191745 · Cited by 50 · see citing works
Li, W., Xu, J.-W., Chai, J.-L., Guo, C., Li, G.-Z., Gao, M., & Liang, X. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001327 · Cited by 50 · see citing works
Roles of inflammatory cell infiltrate in periprosthetic osteolysis
Panez-Toro, I., Heymann, D., Gouin, F., Amiaud, J., Heymann, M., & Córdova, L. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1310262 · Cited by 49 · see citing works
Yu, G., Chen, Y., Yang, N., Zhang, H., Zhang, X., Geng, Y., Zhao, J., Chen, Z., Dong, C., Lin, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202307238 · Cited by 49 · see citing works
Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis
Masters, E. A., Muthukrishnan, G., Ho, L., Gill, A. L., Bentley, K. L. D. M., Galloway, C. A., McGrath, J. L., Awad, H. A., Gill, S. R., & Schwarz, E. M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.723498 · Cited by 44 · see citing works
Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis
Zhang, L., & Wen, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126522 · Cited by 47 · see citing works
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review
Hu, Y., Huang, J., Chen, C., Wang, Y., Hao, Z., Chen, T., Wang, J., & Li, J. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb14010018 · Cited by 44 · see citing works
Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk
Semenistaja, S., Skuja, S., Kadisa, A., & Groma, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044120 · Cited by 47 · see citing works
Non-bone metastatic cancers promote osteocyte-induced bone destruction
Pin, F., Prideaux, M., Huot, J. R., Essex, A. L., Plotkin, L. I., Bonetto, A., & Bonewald, L. F. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.030 · Cited by 36 · see citing works
Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
Wang, Z., Lin, X., Cao, J., Liu, Y.-W., Luo, Z.-W., Rao, S.-S., Wang, Y., Wang, Y.-Y., Chen, C., Zhu, G., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02367-x · Cited by 35 · see citing works
Gong, S., Lang, S., Wang, Y., Li, X., Tian, A., Ma, J., & Ma, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s456545 · Cited by 35 · see citing works
Wang, Z., Niu, Y., Tian, X., Yu, N. H., Yin, X., Xing, Z., Li, Y., Dong, L., & Wang, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007408 · Cited by 35 · see citing works
Seeling, M., Pöhnl, M., Kara, S., Horstmann, N., Riemer, C., Wöhner, M., Liang, C., Brückner, C., Eiring, P., Werner, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.02.019 · Cited by 35 · see citing works
Self-citationTang, Y., Su, S., Yu, R., Liao, C., Dong, Z., Jia, C., Yau, V., Wu, L., Guo, W., & Zheng, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01969-6 · Cited by 35 · see citing works
In-depth phenotyping for clinical stratification of Gaucher disease
D’Amore, S., Page, K., Donald, A., Taiyari, K., Tom, B. D. M., Deegan, P. B., Tan, C. Y., Poole, K. E. S., Jones, S. A., Mehta, A. B., et al. (2021) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-021-02034-6 · Cited by 34 · see citing works
Osteocyte ferroptosis induced by ATF3 / TFR1 contributes to cortical bone loss during ageing
Yin, Y., Chen, G., Yang, C., Wang, J., Peng, J., Huang, X., Tang, Q., & Chen, L. (2024) · Cell Proliferation · doi:10.1111/cpr.13657 · Cited by 33 · see citing works
Roper, P., Shao, C., & Veis, D. (2020) · Cells · doi:10.3390/cells9102157 · Cited by 30 · see citing works
Deng, Z., Ren, Y., Park, M. S., & Kim, H. K. W. (2021) · Bone · doi:10.1016/j.bone.2021.116215 · Cited by 32 · see citing works
Energy homeostasis in the bone
Zhou, M., An, Y.-Z., Guo, Q., Zhou, H., & Luo, X. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.12.009 · Cited by 32 · see citing works
Xie, X., Peng, C. M., Hu, L., Zhou, W., Zhang, D., Knoedler, S. A., Liu, G., Xiong, Y., Xue, H., Hu, Y., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01726-8 · Cited by 27 · see citing works
From death to birth: how osteocyte death promotes osteoclast formation
Zhao, W., Qian, J., Li, J., Su, T., Deng, X., Fu, Y., Liang, X., & Cui, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1551542 · Cited by 26 · see citing works
Osteoclast Activation and Inflammatory Bone Diseases: Focusing on Receptors in Osteoclasts
Zhao, W., Li, J., Su, T., Wang, C., Fu, Y., Li, C., Hua, P., Liang, X., Zhu, Y., & Cui, H. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s507269 · Cited by 27 · see citing works
Lyu, R., Chen, Y., Shuai, Y., Wang, J., Lu, L., Cheng, Q., Cai, J., Mao, C., & Yang, M. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c17554 · Cited by 26 · see citing works
Eggshell Microparticle Reinforced Scaffolds for Regeneration of Critical Sized Cranial Defects
Wu, X., Gauntlett, O. C., Zhang, T., Suvarnapathaki, S., McCarthy, C., Wu, B., & Camci‐Unal, G. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c19884 · Cited by 25 · see citing works
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Yan, M., Tsukasaki, M., Muro, R., Ando, Y., Nakamura, K., Komatsu, N., Nitta, T., Okamura, T., Okamoto, K., & Takayanagi, H. (2023) · Bone Research · doi:10.1038/s41413-023-00277-6 · Cited by 23 · see citing works
Nano-Drug Delivery Systems for Bone Metastases: Targeting the Tumor–Bone Microenvironment
Bakir, M. A., Dawalibi, A., Mufti, M. A., Behiery, A., & Mohammad, K. S. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050603 · Cited by 21 · see citing works
Dai, J., Hu, Z., Zeng, F., Gong, X., Tang, H., Deng, J., Li, J., & Dong, S. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109827 · Cited by 21 · see citing works
TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis
Cui, H., Li, J., Li, X., Su, T., Wen, P., Wang, C., Deng, X., Fu, Y., Zhao, W., Li, C., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117050 · Cited by 20 · see citing works
Huang, J., Ma, T., Wang, C., Wang, Z., Wang, X., Hua, B., Jiang, C., & Yan, Z. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00933-5 · Cited by 20 · see citing works
Ma, C., Park, M. S., do Monte, F. A., Gokani, V., Aruwajoye, O. O., Ren, Y., Liu, X., & Kim, H. K. W. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00322-2 · Cited by 20 · see citing works
Castillo, E. J., Messer, J. G., Abraham, A., Jiron, J. M., Alekseyenko, A. V., Israel, R., Thomas, S., González-Pérez, G., Croft, S., Gohel, A., et al. (2021) · Bone · doi:10.1016/j.bone.2021.115866 · Cited by 20 · see citing works
Zeng, Z., Fei, L., Yang, J., Zuo, J., Huang, Z., & Li, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.783352 · Cited by 20 · see citing works
Wang, J., Xin, Y., Dong, Z., Li, S., & Yang, G. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112974 · Cited by 21 · see citing works
Cox, T. M., Charrow, J., Lukina, E., Mistry, P. K., Foster, M. C., & Peterschmitt, M. (2022) · Genetics in Medicine · doi:10.1016/j.gim.2022.10.011 · Cited by 19 · see citing works
Madel, M., Halper, J., Ibáñez, L., Claire, L., Rouleau, M., Boutin, A., Mahler, A., Pontier-Bres, R., Ciucci, T., Topi, M., et al. (2023) · eLife · doi:10.7554/elife.82037 · Cited by 19 · see citing works
UBE2E3 regulates cellular senescence and osteogenic differentiation of BMSCs during aging
Liu, Y., Cai, G., Chen, P., Jiang, T., & Xia, Z. (2021) · PeerJ · doi:10.7717/peerj.12253 · Cited by 18 · see citing works
Ghost messages: cell death signals spread
Zhang, M., Lin, Y., Chen, R., Yu, H., Li, Y., Chen, M., Dou, C., Yin, P., Zhang, L., & Tang, P. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01004-0 · Cited by 18 · see citing works
Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy
Wu, D., Sun, X., Zhao, Y., Liu, Y., Gan, Z., Zhang, Z., Chen, X., & Cao, Y. (2023) · Bioengineering · doi:10.3390/bioengineering10030365 · Cited by 17 · see citing works
Osteocyte death promotes bone loss
McHugh, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0498-x · Cited by 16 · see citing works
Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis
Dong, X., Liu, H., Yuan, D., Gulati, K., & Liu, Y. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02628d · Cited by 16 · see citing works
Efferocytosis and Bone Dynamics
Batoon, L., Hawse, J. R., McCauley, L. K., Weivoda, M. M., & Roca, H. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00878-y · Cited by 15 · see citing works
Yang, Z., Yuan, Z., & Ma, X.-L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5338182 · Cited by 15 · see citing works
Ye, W., Liao, Y.-L., Liu, X., Wang, Y., Li, T., Zhao, Y., He, Z., Chen, J., Yin, M., Sheng, Y., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.011 · Cited by 14 · see citing works
Basiri, M., Ghaffari, M. E., Ruan, J., Murugesan, V., Kleytman, N., Belinsky, G. S., Akhavan, A., Lischuk, A. W., Guo, L., Klinger, K. W., et al. (2023) · eLife · doi:10.7554/elife.87537 · Cited by 14 · see citing works
Yang, T., Liu, S., Ma, H., Lai, H., Wang, C., Ni, K., Lu, Y., Li, W., Hu, X., Zhou, Z., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.017 · Cited by 14 · see citing works
Hip prosthetic loosening and periprosthetic osteolysis: A commentary
Mjöberg, B. (2022) · World Journal of Orthopedics · doi:10.5312/wjo.v13.i6.574 · Cited by 14 · see citing works
Chen, T., He, X., Zhou, N., Jia-cui, S., Weng, D., & Li, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114253 · Cited by 13 · see citing works
Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis
Wang, G., Meng, Y., Ouyang, W., Zhao, C., & Zhao, W. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1289843 · Cited by 13 · see citing works
Chen, Y., Zhao, R., Yang, L., & Guo, X.-D. E. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100065 · Cited by 13 · see citing works
Gao, X., Yang, J., Gan, X., Lin, Y., Xu, J., Shan, Z., Han, Z., Chen, S., Huang, B., Fan, B., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152044 · Cited by 13 · see citing works
Shi, X., Gao, T., Yu, C., Fu, S., Guo, T., Xu, W., Li, X., Wang, Y., Zhang, J., Jia, X., et al. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01552-6 · Cited by 13 · see citing works
Kaifu, T., Maruhashi, T., Chung, S.-H., Shimizu, K., Nakamura, A., & Iwakura, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1159058 · Cited by 12 · see citing works
Guillem‐Llobat, P., Marín, M., Rouleau, M., Silvestre, A. M., Blin‐Wakkach, C., Ferrándiz, M. L., Guillén, M. I., & Ibáñez, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031710 · Cited by 12 · see citing works
A review of bacterial and osteoclast differentiation in bone infection
Dong, Q., Zhou, J., Feng, M., Kong, L., Fang, B., & Zhang, Z. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107102 · Cited by 11 · see citing works
Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway
Liu, Y., Fu, Z., Wang, X., Yang, Q., Liu, S., & Zhu, D. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1527316 · Cited by 11 · see citing works
Macrophages and osteoclasts: similarity and divergence between bone phagocytes
Halper, J., Dolfi, B., Ivanov, S., Madel, M., & Blin‐Wakkach, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1683872 · Cited by 11 · see citing works
Pathogenesis, assessment, and management of bone loss in axial spondyloarthritis
Nakamura, A., & Towheed, T. (2023) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2023.152345 · Cited by 10 · see citing works
Xiang, X.-N., He, H., & He, C. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000002094 · Cited by 10 · see citing works
Periprosthetic osteolysis: Mechanisms and potential treatment strategies
Yao, F., Bao, Y., Meng, Q., Chen, Y., Zhao, L., Wang, P. Y., & Zhou, B. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111758 · Cited by 10 · see citing works
Ohori, F., Kitaura, H., Marahleh, A., Ma, J., Miura, M., Ren, J., Narita, K., Fan, Z., Lin, A., & Mizoguchi, I. (2025) · Scientific Reports · doi:10.1038/s41598-025-04697-8 · Cited by 10 · see citing works
Lin, C.-Y., Song, X., Seaman, K., & You, L. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00748-5 · Cited by 10 · see citing works
Tsubosaka, M., Maruyama, M., Lui, E., Moeinzadeh, S., Huang, E. E., Kushioka, J., Hirata, H., Jain, C. M., Storaci, H. W., Chan, C. K., et al. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37495 · Cited by 10 · see citing works
Shao, W., Li, Z., Wang, B., Gong, S., Wang, P., Song, B., Chen, Z.-X., & Feng, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11040992 · Cited by 9 · see citing works
Osteoclast: The novel whistleblower in osteonecrosis of the femoral head
Qi, M., Wang, Y., Yuan, T., Su, Y., Li, Z., & Sun, S. (2023) · Gene Reports · doi:10.1016/j.genrep.2023.101833 · Cited by 10 · see citing works
Carroll, K. A., Sawden, M., & Sharma, S. (2025) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00900-3 · Cited by 8 · see citing works
The Role of Persistent Inflammation in the Pathogenesis of Infected Nonunion: A Narrative Review
Liu, T., Li, F.-J., Yan, Y., Gao, S., Zhou, D.-Q., Jiang, X., Song, C., Fu, Z.-J., & Liu, Z.-C. (2025) · Immunity, Inflammation and Disease · doi:10.1002/iid3.70260 · Cited by 9 · see citing works
Qian, H., Jia, F., & Qin, H. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05512-w · Cited by 7 · see citing works
Pu, H., Ding, L., Jiang, P., Li, G., Wang, W., Jiang, J., & Gan, X. (2025) · Biomedicines · doi:10.3390/biomedicines13102426 · Cited by 7 · see citing works
Panahipour, L., Kargarpour, Z., Laggner, M., Mildner, M., Ankersmit, H. J., & Gruber, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228569 · Cited by 7 · see citing works
Development and validation of a gene signature predicting the risk of postmenopausal osteoporosis
Yuan, W., Yang, M., & Zhu, Y. (2022) · Bone and Joint Research · doi:10.1302/2046-3758.118.bjr-2021-0565.r1 · Cited by 7 · see citing works
Zhang, Z., Zhou, C., & Yu, L. (2024) · BMC Molecular and Cell Biology · doi:10.1186/s12860-024-00523-7 · Cited by 6 · see citing works
Jin, Y., Wang, Y., Wang, C., Zhang, L., Gao, D., Liu, H., Cao, Q., Bian, Y., Bian, Y., & Wang, Y. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60864-8 · Cited by 6 · see citing works
Sun, L., Kuang, S., Li, Y., Wang, G., Sun, J., Zhou, F., & Zhang, C. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s533552 · Cited by 6 · see citing works
- Authors
- Andreev, D., Liu, M., Weidner, D., Kachler, K., Faas, M., Grüneboom, A., Schlötzer-Schrehardt, U., Muñoz, L. E., Steffen, U., Grötsch, B., Killy, B., Krönke, G., Luebke, A. M., Niemeier, A., Wehrhan, F., Lang, R., Schett, G., & Bozec, A.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2020-08-10
- Volume
- 130
- Issue
- 9
- Pages
- 4811-4830
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7456234
- OpenAlex
- W3047914933
- Cited by
- 188
- References
- 68
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 41 · 2023: 35 · 2022: 24 · 2021: 19 · 2020: 6
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (CRC‐1181, FOR 2886 (TP02, FOR2886, BO‐3811/5‐1, BO-3811/6-1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteoclastogenesis, Mincle, damage-associated molecular patterns, bone loss, avascular necrosis, fracture healing, ITAM signaling, calcium signaling, oxidative phosphorylation, RANKL
- MeSH terms
- RNA-Seq, Animals, Bone Resorption, Membrane Proteins, Necrosis, Osteoclasts, Osteocytes, Mice, Knockout, Lectins, C-Type, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review