Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

Inflammation and Atherosclerosis

Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680 · see citing works

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

Physiological Roles of Mitochondrial Reactive Oxygen Species

Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632 · see citing works

NF-κB, Inflammation, and Metabolic Disease

Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952 · see citing works

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works

TLR signaling

Kawai, T., & Akira, S. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2006.12.004 · Cited by 1,404 · see citing works

T-Cell mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.

Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., et al. (2000) · Nature · doi:10.1038/35046102 · Cited by 1,358 · see citing works

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241 · see citing works

Insulin sensitivity: Modulation by nutrients and inflammation

Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · see citing works

Skeletal remodeling in health and disease

Zaidi, M. (2007) · Nature Medicine · doi:10.1038/nm1593 · Cited by 1,069 · see citing works

Nutrient sensing and inflammation in metabolic diseases

Hotamisligil, G. S., & Erbay, E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2449 · Cited by 1,040 · see citing works

Obesity, inflammation, and atherosclerosis

Rocha, V. Z., & Libby, P. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.55 · Cited by 994 · see citing works

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state

Kushnareva, Y., Murphy, A. N., & Andreyev, A. Y. (2002) · Biochemical Journal · doi:10.1042/bj20021121 · Cited by 677 · see citing works

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

Tal, M. C., Sasai, M., Lee, H. K., Yordy, B., Shadel, G. S., & Iwasaki, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807694106 · Cited by 573 · see citing works

PPAR-γ regulates osteoclastogenesis in mice

Wan, Y., Chong, L.-W., & Evans, R. M. (2007) · Nature Medicine · doi:10.1038/nm1672 · Cited by 513 · see citing works

Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Jimi, E., Aoki, K., Saito, H., D’Acquisto, F., May, M. J., Nakamura, I., Sudo, T., Kojima, T., Okamoto, F., Fukushima, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1054 · Cited by 500 · see citing works

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

Karamanlidis, G., Lee, C. F., Garcia‐Menendez, L., Kolwicz, S. C., Suthammarak, W., Gong, G., Sedensky, M. M., Morgan, P. G., Wang, W., & Tian, R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.002 · Cited by 469 · see citing works

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

Kruse, S. E., Watt, W. C., Marcinek, D. J., Kapur, R. P., Schenkman, K. A., & Palmiter, R. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.004 · Cited by 420 · see citing works

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

Ishii, K.-A., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., et al. (2009) · Nature Medicine · doi:10.1038/nm.1910 · Cited by 410 · see citing works

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

Zhao, B., Takami, M., Yamada, A., Wang, X., Koga, T., Hu, X., Tamura, T., Ozato, K., Choi, Y., Ivashkiv, L. B., et al. (2009) · Nature Medicine · doi:10.1038/nm.2007 · Cited by 313 · see citing works

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

Distelmaier, F., Koopman, W. J. H., van den Heuvel, L. P., Rodenburg, R. J., Mayatepek, E., Willems, P. H. G. M., & Smeitink, J. A. M. (2008) · Brain · doi:10.1093/brain/awp058 · Cited by 310 · see citing works

Rosiglitazone Induces Decreases in Bone Mass and Strength that Are Reminiscent of Aged Bone

Lazarenko, O. P., Rzońca, S., Hogue, W. R., Swain, F. L., Suva, L. J., & Lecka‐Czernik, B. (2007) · Endocrinology · doi:10.1210/en.2006-1587 · Cited by 302 · see citing works

A mitochondrial etiology of Alzheimer and Parkinson disease

Coskun, P. E., Wyrembak, J., Schriner, S. E., Chen, H.-W., Marciniack, C., LaFerla, F. M., & Wallace, D. C. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.008 · Cited by 297 · see citing works

Mitochondria: Sovereign of inflammation?

Tschopp, J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141436 · Cited by 294 · see citing works

Respiratory chain complex I deficiency

Kirby, D. M., Crawford, M., Cleary, M., Dahl, H. ‐. M., Dennett, X., & Thorburn, D. R. (1999) · Neurology · doi:10.1212/wnl.52.6.1255 · Cited by 266 · see citing works

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

Wei, W., Wang, X., Yang, M., Smith, L. C., Dechow, P. C., & Wan, Y. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.015 · Cited by 243 · see citing works

Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation

Samuvel, D. J., Sundararaj, K. P., Nareika, A., Lopes-Virella, M. F., & Huang, Y. Q. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802059 · Cited by 220 · see citing works

Mitochondria-Rich, Proton-Secreting Epithelial Cells

Brown, D., & Breton, S. (1996) · Journal of Experimental Biology · doi:10.1242/jeb.199.11.2345 · Cited by 206 · see citing works

Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by β-Catenin

Wei, W., Zeve, D., Suh, J. M., Wang, X., Du, Y., Zerwekh, J. E., Dechow, P. C., Graff, J. M., & Wan, Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05980-11 · Cited by 181 · see citing works

Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes

Zinman, B., Haffner, S. M., Herman, W. H., Holman, R. R., Lachin, J. M., Kravitz, B. G., Paul, G., Jones, N. C., Aftring, R. P., Viberti, G. C., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0572 · Cited by 180 · see citing works

Enhanced Marrow Adipogenesis and Bone Resorption in Estrogen-Deprived Rats Treated with the PPARgamma Agonist BRL49653 (Rosiglitazone)

Sottile, V., Seuwen, K., & Kneissel, M. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0224-8 · Cited by 178 · see citing works

Mitochondrial oxidative stress and the metabolic syndrome

James, A. M., Collins, Y., Logan, A., & Murphy, M. P. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.008 · Cited by 145 · see citing works

PPARγ in bone homeostasis

Wan, Y. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.006 · Cited by 134 · see citing works

Modulation of Osteoclastogenesis by Fatty Acids

Cornish, J., MacGibbon, A. K. H., Lin, J., Watson, M., Callon, K. E., Tong, P. C., Dunford, J. E., van der Does, Y., Williams, G. A., Grey, A. B., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0111 · Cited by 128 · see citing works

Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption

Chang, E., Ha, J., Oerlemans, F. T. J. J., Lee, Y. J., Lee, S. W., Ryu, J., Kim, H. J., Lee, Y., Kim, H., Choi, J., et al. (2008) · Nature Medicine · doi:10.1038/nm.1860 · Cited by 114 · see citing works

Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milkPreprint

Wan, Y., Saghatelian, A., Chong, L.-W., Zhang, C.-L., Cravatt, B. F., & Evans, R. M. (2007) · Genes & Development · doi:10.1101/gad.1567207 · Cited by 103 · see citing works

Palmitic Acid and DGAT1 Deficiency Enhance Osteoclastogenesis, while Oleic Acid-Induced Triglyceride Formation Prevents It

Drosatos-Tampakaki, Z., Drosatos, K., Siegelin, Y., Gong, S., Khan, S., Dyke, T. V., Goldberg, I., Schulze, P. C., & Schulze-Späte, U. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2150 · Cited by 101 · see citing works

Hair and Skin Disorders as Signs of Mitochondrial Disease

Bodemer, C., Rötig, A., Rustin, P., et al. (1999) · PEDIATRICS · doi:10.1542/peds.103.2.428 · Cited by 96 · see citing works

Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression

Kwak, H. B., Lee, B. K., Oh, J., Yeon, J., Choi, S., Cho, H. J., Lee, M. S., Kim, J.-J., Bae, J., Kim, S. H., et al. (2009) · Bone · doi:10.1016/j.bone.2009.10.042 · Cited by 88 · see citing works

Cell Biological Consequences of Mitochondrial NADH: Ubiquinone Oxidoreductase Deficiency

Smeitink, J. A. M., van den Heuvel, L., Koopman, W. J. H., Nijtmans, L. G. J., Ugalde, C., & Willems, P. H. G. M. (2004) · Current Neurovascular Research · doi:10.2174/1567202043480224 · Cited by 59 · see citing works

Identification of P gene mutations in individuals with oculocutaneous albinism in sub-Saharan Africa

Kerr, R. A., Stevens, G., Manga, P., Salm, S. N., John, P. R., Haw, T., & Ramsay, M. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200002)15:2 · Cited by 50 · see citing works

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicityPreprint

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A., & Wan, Y. (2012) · Genes & Development · doi:10.1101/gad.191031.112 · Cited by 47 · see citing works

The molecular basis of human complex I deficiency

Tucker, E. J., Compton, A. G., Calvo, S. E., & Thorburn, D. R. (2011) · IUBMB Life · doi:10.1002/iub.495 · Cited by 44 · see citing works

Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates

Du, Y., Yang, M., Wei, W., Huynh, H., Herz, J., Saghatelian, A., & Wan, Y. (2012) · Nature Communications · doi:10.1038/ncomms2011 · Cited by 31 · see citing works

Hair anomalies as a sign of mitochondrial disease

Silengo, M., Valenzise, M., Spada, M., et al. (2003) · European Journal of Pediatrics · doi:10.1007/s00431-003-1228-5 · Cited by 25 · see citing works

Skin manifestations of a patient with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS syndrome)

Kubota, Y., Ishii, T., Sugihara, H., et al. (1999) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(99)70123-4 · Cited by 22 · see citing works

Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes

Senn, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.a109.513304 · Cited by 8 · see citing works

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960 · see citing works

Krebs cycle Reborn in macrophage immunometabolism

Ryan, D. G., & O'Neill, L. A. J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081619-104850 · Cited by 444 · see citing works

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

Garaude, J., Acín-Pérez, R., Martínez-Cano, S., Enamorado, M., Ugolini, M., Nistal-Villán, E., Hervás-Stubbs, S., Pelegrín, P., Sander, L. E., Enríquez, J. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3509 · Cited by 313 · see citing works

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

Andreev, D., Liu, M., Weidner, D., Kachler, K., Faas, M., Grüneboom, A., Schlötzer-Schrehardt, U., Muñoz, L. E., Steffen, U., Grötsch, B., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134214 · Cited by 188 · see citing works

Reprogramming of mitochondrial metabolism by innate immunity

Garaude, J. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.010 · Cited by 33 · see citing works

Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations

Sun, D., Wei, Y., Zheng, H.-X., Jin, L., & Wang, J. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00128 · Cited by 21 · see citing works

Regulation of osteoclast-mediated bone resorption by microRNA

Ji, L., Li, X., He, S., & Chen, S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04298-y · Cited by 22 · see citing works

Endotoxin inhibition of macrophage-mediated bone resorption

Kahn, A., & Teitelbaum, S. L. (1981) · Calcified Tissue International · doi:10.1007/bf02409448 · Cited by 17 · see citing works

Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops

Li, J., Zeng, L., Xie, J., Yue, Z., Deng, H., Ma, X., Zheng, C., Wu, X., Luo, J., & Liu, M. (2015) · Scientific Reports · doi:10.1038/srep17605 · Cited by 49 · see citing works

A Comparison of Osteoclast-Rich and Osteoclast-Poor Osteopetrosis in Adult Mice Sheds Light on the Role of the Osteoclast in Coupling Bone Resorption and Bone Formation

Thudium, C. S., Moscatelli, I., Flores, C., Thomsen, J. S., Brüel, A., Gudmann, N. S., Hauge, E.-M., Karsdal, M. A., Richter, J., & Henriksen, K. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9865-4 · Cited by 36 · see citing works

Osteoclast function and bone-resorbing activity: An overview

Soysa, N. S., & Alles, N. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.05.019 · Cited by 131 · see citing works