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Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
Open accessAbstract
Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed, several skeletal diseases, such as bone fracture, osteonecrosis, and inflammation are characterized by excessive osteocyte death. Herein we show that osteoclasts sense damage-associated molecular patterns (DAMPs) released by necrotic osteocytes via macrophage-inducible C-type lectin (Mincle), which induced their differentiation and triggered bone loss. Osteoclasts showed robust Mincle expression upon exposure to necrotic osteocytes in vitro and in vivo. RNA sequencing and metabolic analyses demonstrated that Mincle activation triggers osteoclastogenesis via ITAM-based calcium signaling pathways, skewing osteoclast metabolism toward oxidative phosphorylation. Deletion of Mincle in vivo effectively blocked the activation of osteoclasts after induction of osteocyte death, improved fracture repair, and attenuated inflammation-mediated bone loss. Furthermore, in patients with osteonecrosis, Mincle was highly expressed at skeletal sites of osteocyte death and correlated with strong osteoclastic activity. Taken together, these data point to what we believe is a novel DAMP-mediated process that allows osteoclast activation and bone loss in the context of osteocyte death.
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“DAMPs can directly regulate osteoclast formation by activating the membrane-bound C-type lectin receptor Mincle. Mincle activation triggers calcium signaling and oxidative phosphorylation in osteoclasts, inducing osteoclast differentiation.74”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [74]
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Metadata
- Authors
- Andreev, D., Liu, M., Weidner, D., Kachler, K., Faas, M., Grüneboom, A., Schlötzer-Schrehardt, U., Muñoz, L. E., Steffen, U., Grötsch, B., Killy, B., Krönke, G., Luebke, A. M., Niemeier, A., Wehrhan, F., Lang, R., Schett, G., & Bozec, A.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2020-08-10
- Volume
- 130
- Issue
- 9
- Pages
- 4811-4830
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7456234
- OpenAlex
- W3047914933
- Cited by
- 188
- References
- 68
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 41 · 2023: 35 · 2022: 24 · 2021: 19 · 2020: 6
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (CRC‐1181, FOR 2886 (TP02, FOR2886, BO‐3811/5‐1, BO-3811/6-1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteoclastogenesis, Mincle, damage-associated molecular patterns, bone loss, avascular necrosis, fracture healing, ITAM signaling, calcium signaling, oxidative phosphorylation, RANKL
- MeSH terms
- RNA-Seq, Animals, Bone Resorption, Membrane Proteins, Necrosis, Osteoclasts, Osteocytes, Mice, Knockout, Lectins, C-Type, Mice
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