Cited by 269Chemokine receptors and signalingNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease

Xia, Meng Qi, Bacskai, Brian J, Knowles, Roger B, Qin, Shi Xin, Hyman, Bradley T·2000·Journal of Neuroimmunology

Abstract

Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed in a subpopulation of astrocytes in normal brain, and was markedly elevated in astrocytes in AD brains. Many IP-10(+) astrocytes were associated with senile plaques and had an apparently coordinated upregulation of MIP-1beta. Moreover, we showed that CXCR3 ligands, IP-10 and Mig, were able to activate ERK1/2 pathway in mouse cortical neurons, suggesting a novel mechanism of neuronal-glial interaction.

Integrity signals

Registry

Crossref · 10.1016/s0165-5728(00)00285-x

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 55 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Xia, M. Q., Bacskai, B. J., Knowles, R. B., Qin, S. X., & Hyman, B. T.
Affiliations
Harvard University (US)
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2000-08
Volume
108
Issue
1-2
Pages
227-235
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2002670780
Cited by
269
References
55
Citations by year
2026: 6 · 2025: 11 · 2024: 15 · 2023: 16 · 2022: 14 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 3 · 2015: 4 · 2014: 11 · 2013: 13 · 2012: 4
FWCI
4.86
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (P50 AG05134, P50AG005134)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
CXCR3, CXCL10, CCL22, MIP-1β, Alzheimer's disease, reactive astrocytes, neurons, ERK1/2 activation, neuron-glia interactions, amyloid plaques, chemokines, neuroinflammation, cortical neurons
MeSH terms
Aged, Alzheimer Disease, Animals, Astrocytes, Cells, Cultured, Cerebral Cortex, Enzyme Activation, Female, Glial Fibrillary Acidic Protein, Humans, Ligands, Neurons, Phosphorylation, Up-Regulation, Macrophage Inflammatory Proteins, Receptors, Chemokine, Chemokines, CXC, Gene Expression Profiling, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Intercellular Signaling Peptides and Proteins, Mice, Chemokine CXCL10, Receptors, CXCR3, Chemokine CXCL9, Chemokine CCL4, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review