Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease
Abstract
Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed in a subpopulation of astrocytes in normal brain, and was markedly elevated in astrocytes in AD brains. Many IP-10(+) astrocytes were associated with senile plaques and had an apparently coordinated upregulation of MIP-1beta. Moreover, we showed that CXCR3 ligands, IP-10 and Mig, were able to activate ERK1/2 pathway in mouse cortical neurons, suggesting a novel mechanism of neuronal-glial interaction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CXCL10 and CCL3 were found to be elevated in patients with AD and associated with neurological deficits.
“were found to be elevated in patients with AD and associated with neurological deficits (57–60).”
From Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis (2021) · cites this paper as [59]
Cites
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,494 · see citing works
Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,338 · see citing works
Baggiolini, M., Dewald, B., & Moser, B. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.675 · Cited by 2,193 · see citing works
A new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013 · see citing works
Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1422 · Cited by 1,359 · see citing works
Self-citationHarrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works
Sørensen, T. L., Tani, M., Jensen, J. S., Pierce, V., Lucchinetti, C. F., Folcik, V. A., Qin, S., Rottman, J., Sellebjerg, F. T., Strieter, R. M., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5150 · Cited by 993 · see citing works
Self-citationCCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
He, J., Chen, Y., Farzan, M., Choe, H., Öhagen, Å., Gartner, S., Busciglio, J. A., Yang, X., Hofmann, W., Newman, W., et al. (1997) · Nature · doi:10.1038/385645a0 · Cited by 915 · see citing works
Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2009 · Cited by 870 · see citing works
Legler, D. F., Loetscher, M., Roos, R. S., Clark‐Lewis, I., Baggiolini, M., & Moser, B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.655 · Cited by 838 · see citing works
Griffin, W. S. T., Sheng, J. G., Royston, M. C., Gentleman, S., McKenzie, J. E., Graham, D. I., Roberts, G. W., & Mrak, R. E. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 708 · see citing works
Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
Meucci, O., Fatatis, A., Simen, A. A., Bushell, T. J., Gray, P. W., & Miller, R. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14500 · Cited by 692 · see citing works
Chemokine receptors: Gateways to inflammation and infection
Premack, B. A., & Schall, T. J. (1996) · Nature Medicine · doi:10.1038/nm1196-1174 · Cited by 630 · see citing works
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state.
Drewes, G., Lichtenberg‐Kraag, B., Döring, F., Mandelkow, E. M., Biernat, J., Goris, J., Dorée, M., & Mandelkow, E. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05272.x · Cited by 565 · see citing works
MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia
Alessandrini, A., Namura, S., Moskowitz, M. A., & Bonventre, J. V. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12866 · Cited by 464 · see citing works
Expression of chemokine receptors by subsets of neurons in the central nervous system
Horuk, R., Martin, A. W., Wang, Z., Schweitzer, L., Gerassimides, A., Guo, H.-D., Lu, Z., Hesselgesser, J., Perez, H. D., Kim, J., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2882 · Cited by 385 · see citing works
Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K. S., García-Zepeda, E. A., Hamid, Q. A., & Luster, A. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3549 · Cited by 373 · see citing works
Nishiyori, A., Minami, M., Ohtani, Y., Takami, S., Yamamoto, J., Kawaguchi, N., Kume, T., Akaike, A., & Satoh, M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00583-3 · Cited by 367 · see citing works
Johnstone, M., Gearing, A. J. H., & Miller, K. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00226-4 · Cited by 313 · see citing works
Perry, G., Roder, H., Nunomura, A., Takeda, A., Friedlich, A., Zhu, X.-W., Raina, A., Holbrook, N., Siedlak, S., Harris, P., et al. (1999) · NeuroReport · doi:10.1097/00001756-199908020-00035 · Cited by 296 · see citing works
Rogers, J. T., Leiter, L. M., McPhee, J., Cahill, C. M., Zhan, S.-S., Potter, H., & Nilsson, L. N. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6421 · Cited by 290 · see citing works
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins
Fields, T. A., & Casey, P. J. (1997) · Biochemical Journal · doi:10.1042/bj3210561 · Cited by 280 · see citing works
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease
Xia, M., & Hyman, B. T. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029743 · Cited by 269 · see citing works
Self-citationSheng, J. G., Ito, K., Skinner, R. D., Mrak, R. E., Rovnaghi, C. R., van Eldik, L. J., & Griffin, W. S. T. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00104-2 · Cited by 269 · see citing works
Xia, M., Qin, S., Wu, L.-J., Mackay, C., & Hyman, B. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65542-3 · Cited by 267 · see citing works
Self-citationFukunaga, K., & Miyamoto, E. (1998) · Molecular Neurobiology · doi:10.1007/bf02740604 · Cited by 256 · see citing works
Lavi, E., Strizki, J., Ulrich, A. M., Zhang, W., Fu, L., Wang, Q., O’Connor, M. J., Hoxie, J. A., & González‐Scarano, F. (1997) · Europe PMC (PubMed Central) · Cited by 238 · see citing works
Araujo, D. M., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90400-h · Cited by 237 · see citing works
Veeranna, Amin, N. D., Ahn, N. G., Jaffe, H., Winters, C. A., Grant, P. G., & Pant, H. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04008.1998 · Cited by 234 · see citing works
Murray, B., Alessandrini, A., Cole, A. J., Yee, A. G., & Furshpan, E. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11975 · Cited by 224 · see citing works
Zaballos, Á., Gutiérrez, J., Varona, R., Ardavı́n, C., & Márquez, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.5671 · Cited by 203 · see citing works
Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
Asensio, V. C., & Campbell, I. L. (1997) · Journal of Virology · doi:10.1128/jvi.71.10.7832-7840.1997 · Cited by 190 · see citing works
Chemokines and chemokine receptors in CNS pathology
Glabinski, A. R., & Ransohoff, R. M. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029740 · Cited by 184 · see citing works
Bailey, C. H., Kaang, B., Chen, M., Martin, K. C., Lim, C., Casadio, A., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80331-1 · Cited by 180 · see citing works
Rundén‐Pran, E., Seglen, P. O., Haug, F. Š., Ottersen, O. P., Wieloch, T. W., Shamloo, M., & Laake, J. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07296.1998 · Cited by 167 · see citing works
Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.
Sasseville, V. G., Smith, M. M., Mackay, C. R., Pauley, D. R., Mansfield, K. G., Ringler, D. J., & Lackner, A. A. (1996) · Europe PMC (PubMed Central) · Cited by 165 · see citing works
Regulated production of the interferon‐γ‐inducible protein−10 (IP‐10) chemokine by human neutrophils
Cassatella, M. A., Gasperini, S., Calzetti, F., Bertagnin, A., Luster, A. D., & McDonald, P. P. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270117 · Cited by 143 · see citing works
A Kinase to Remember: Dual Roles for MAP Kinase in Long-Term Memory
Kornhauser, J. M., & Greenberg, M. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80322-0 · Cited by 132 · see citing works
Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.
Xia, M., Qin, S., McNamara, M. J., Mackay, C. R., & Hyman, B. T. (1997) · Europe PMC (PubMed Central) · Cited by 131 · see citing works
Self-citationTani, M., Glabinski, A. R., Tuohy, V. K., Stoler, M. H., Estes, M. L., & Ransohoff, R. M. (1996) · Europe PMC (PubMed Central) · Cited by 124 · see citing works
Jones, S. A., Moser, B., & Thelen, M. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00397-r · Cited by 111 · see citing works
Trojanowski, J., Mawal-Dewan, M., Schmidt, M., Martin, J. A., & Lee, V. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91286-2 · Cited by 91 · see citing works
Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ
Ragozzino, D., Giovannelli, A., Mileo, A. M., Limatola, C., Santoni, A., & Eusebi, F. (1998) · Neuroreport · doi:10.1097/00001756-199811160-00011 · Cited by 76 · see citing works
Li, B., Veeranna, Gu, J., Grant, P. G., & Pant, H. C. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00372.x · Cited by 60 · see citing works
Knowles, R. B., Chin, J., Ruff, C. T., & Hyman, B. T. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199910000-00007 · Cited by 59 · see citing works
Self-citationSun, D., Hu, X., Liu, X., Whitaker, J. N., & Walker, W. S. G. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970501)48:3 · Cited by 57 · see citing works
Shyamala, V., & Khoja, H. (1998) · Biochemistry · doi:10.1021/bi9811415 · Cited by 52 · see citing works
Vanguri, P. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)00131-7 · Cited by 49 · see citing works
Fisher, S. N., Vanguri, P., Shin, H. S., & Shin, M. L. (1995) · Brain Behavior and Immunity · doi:10.1006/brbi.1995.1031 · Cited by 37 · see citing works
Interferon-Inducible Protein-10 and the Pathogenesis of Cutaneous T-Cell Lymphomas
Sarris, A. H., Daliani, D., Ulmer, R., Crow, M. K., Broxmeyer, H. E., Pugh, W. C., Reiß, M., Cabanillas, F., Deisseroth, A. B., & Duvic, M. A. (1996) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199609045718 · Cited by 14 · see citing works
Ohtani, Y., Minami, M., Kawaguchi, N., Nishiyori, A., Yamamoto, J., Takami, S., & Satoh, M. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)82046-4 · Cited by 4 · see citing works
Flagged first, then by citations
2 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
González‐Scarano, F., & Martín‐García, J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1527 · Cited by 1,095 · see citing works
The blood-brain barrier in Alzheimer’s disease
Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767 · see citing works
Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639 · see citing works
Chemokines, neuronal–glial interactions, and central processing of neuropathic pain
Gao, Y., & Ji, R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.002 · Cited by 629 · see citing works
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00822-1 · Cited by 531 · see citing works
Cartier, L., Hartley, O., Dubois‐Dauphin, M., & Krause, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.021 · Cited by 507 · see citing works
Chemokines and Their Receptors in the Central Nervous System
Bajetto, A., Bonavia, R., Barbero, S., Florio, T., & Schettini, G. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0214 · Cited by 416 · see citing works
Human Astrocytes: Secretome Profiles of Cytokines and Chemokines
Choi, S. S., Lee, H. J., Lim, I., Satoh, J., & Kim, S. U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092325 · Cited by 411 · see citing works
Garwood, C. J., Pooler, A. M., Atherton, J., Hanger, D. P., & Noble, W. (2011) · Cell Death & Disease · doi:10.1038/cddis.2011.50 · Cited by 379 · see citing works
The Multifaceted Profile of Activated Microglia
Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 323 · see citing works
Bajetto, A., Bonavia, R., Barbero, S., & Schettini, G. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01091.x · Cited by 318 · see citing works
CXCR3 ligands in disease and therapy
Raemdonck, K. V., den Steen, P. E. V., Liekens, S., Damme, J. V., & Struyf, S. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.11.009 · Cited by 313 · see citing works
Chemokine receptors: signposts to brain development and disease
Tran, P. B., & Miller, R. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1116 · Cited by 295 · see citing works
Müller, M., Carter, S., Hofer, M. J., & Campbell, I. L. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01089.x · Cited by 293 · see citing works
Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease
Li, C., Zhao, R., Gao, K., Wei, Z. Z., Yin, M. Y., Lau, L. T., Chui, D., & Yu, A. C. (2011) · Current Alzheimer Research · doi:10.2174/156720511794604543 · Cited by 291 · see citing works
Intrathecal Chemokine Synthesis in Mild Cognitive Impairment and Alzheimer Disease
Galimberti, D., Schoonenboom, N., Scheltens, P., Fenoglio, C., Bouwman, F., Venturelli, E., Guidi, I., Blankenstein, M. A., Bresolin, N., & Scarpini, E. (2006) · Archives of Neurology · doi:10.1001/archneur.63.4.538 · Cited by 289 · see citing works
MCP‐1 (CCL2) protects human neurons and astrocytes from NMDA or HIV‐tat‐induced apoptosis
Eugenin, E. A., D’Aversa, T. G., Lopez, L., Calderon, T. M., & Berman, J. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01775.x · Cited by 288 · see citing works
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279 · see citing works
Fingolimod provides long‐term protection in rodent models of cerebral ischemia
Wei, Y., Yemişçi, M., Kim, H., Yung, L., Shin, H. K., Hwang, S., Guo, S., Qin, T., Alsharif, N., Brinkmann, V., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22186 · Cited by 277 · see citing works
Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis
Bagyinszky, E., Giau, V. V., Shim, K., Suk, K., An, S. S. A., & Kim, S. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.03.031 · Cited by 265 · see citing works
CXCR3-Dependent Microglial Recruitment Is Essential for Dendrite Loss after Brain Lesion
Rappert, A., Bechmann, I., Pivneva, T., Mahlo, J., Biber, K., Nolte, C., Kovac, A. D., Gerard, C., Boddeke, H. W. G. M., Nitsch, R., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2451-04.2004 · Cited by 259 · see citing works
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction
Victorelli, S., Lagnado, A., Halim, J., Moore, W., Talbot, D., Barrett, K., Chapman, J., Birch, J., Ogrodnik, M., Meves, A., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019101982 · Cited by 258 · see citing works
CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration
Koper‐Lenkiewicz, O. M., Kamińska, J., Sawicki, K., & Kemona, H. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/68846 · Cited by 217 · see citing works
Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease
Farfara, D., Lifshitz, V., & Frenkel, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00314.x · Cited by 216 · see citing works
Jorfi, M., Park, J., Hall, C. K., Lin, C.-C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01415-3 · Cited by 214 · see citing works
Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks
Domingues, C., Silva, O. A. B. D. C. E., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 212 · see citing works
Neuronal Chemokines: Versatile Messengers In Central Nervous System Cell Interaction
Haas, A. H. D., van Weering, H. R. J., de Jong, E. K., Boddeke, H. W. G. M., & Biber, K. P. H. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0036-8 · Cited by 182 · see citing works
van Marle, G., Henry, S. D., Todoruk, T. R., Sullivan, A., Silva, C., Rourke, S. B., Holden, J. K., McArthur, J. C., Gill, M. J., & Power, C. (2004) · Virology · doi:10.1016/j.virol.2004.08.024 · Cited by 180 · see citing works
Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.
(2014) · Europe PMC (PubMed Central) · Cited by 177 · see citing works
Croitoru‐Lamoury, J., Guillemin, G. J., Boussin, F. D., Mognetti, B., Gigout, L. I., Chéret, A., Vaslin, B., Grand, R. L., Brew, B. J., & Dormont, D. (2003) · Glia · doi:10.1002/glia.10181 · Cited by 177 · see citing works
CXCL10‐induced cell death in neurons: role of calcium dysregulation
Sui, Y., Stehno‐Bittel, L., Li, S., Loganathan, R., Dhillon, N. K., Pinson, D. M., Nath, A., Kolson, D. L., Narayan, O., & Buch, S. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04631.x · Cited by 173 · see citing works
Chemokines and Chemokine Receptors in Neurological Disease: Raise, Retain, or Reduce?
Savarin-Vuaillat, C., & Ransohoff, R. M. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.07.004 · Cited by 173 · see citing works
A role for human brain pericytes in neuroinflammation
Jansson, D., Rustenhoven, J., Feng, S. X., Hurley, D., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-104 · Cited by 168 · see citing works
Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives
McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 167 · see citing works
Cerciat, M., Unkila, M., García‐Segura, L. M., & Arévalo, M. (2009) · Glia · doi:10.1002/glia.20904 · Cited by 160 · see citing works
CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model
Krauthausen, M., Kummer, M. P., Zimmermann, J., Reyes-Irisarri, E., Terwel, D., Bulic, B., Heneka, M. T., & Müller, M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66771 · Cited by 147 · see citing works
Chemokine Receptor CXCR3: An Unexpected Enigma
Liu, L., Callahan, M. K., Huang, D., & Ransohoff, R. M. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)68006-4 · Cited by 145 · see citing works
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome
Flores-Aguilar, L., Iulita, M. F., Kovecses, O., Torres, M. D., Levi, S. M., Zhang, Y., Askenazi, M., Wisniewski, T., Busciglio, J., & Cuello, A. C. (2020) · Brain · doi:10.1093/brain/awaa326 · Cited by 138 · see citing works
Cytokines and Myelination in the Central Nervous System
Schmitz, T., & Chew, L. (2008) · The Scientific World JOURNAL · doi:10.1100/tsw.2008.140 · Cited by 137 · see citing works
Qin, X., Wan, Y., & Wang, X. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20612 · Cited by 138 · see citing works
Sui, Y., Potula, R., Dhillon, N. K., Pinson, D. M., Li, S., Nath, A., Anderson, C. F., Turchan, J., Kolson, D. L., Narayan, O., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63714-5 · Cited by 137 · see citing works
de Jong, E. K., Dijkstra, I. M., Hensens, M., Brouwer, N., van Amerongen, M. J., Liem, R. S. B., Boddeke, H. W. G. M., & Biber, K. P. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-05.2005 · Cited by 136 · see citing works
Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice
McManus, R. M., Higgins, S. C., Mills, K. H. G., & Lynch, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.025 · Cited by 132 · see citing works
Yun, H.-M., Kim, H. S., Kr, P., Shin, J., Kang, A.-R., Lee, K. I., Song, S., Kim, Y.-B., Han, S., Chung, H.-M., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.490 · Cited by 128 · see citing works
Role of chemokine systems in cancer and inflammatory diseases
Li, H., Wu, M., & Zhao, X. (2022) · MedComm · doi:10.1002/mco2.147 · Cited by 127 · see citing works
Maru, S., Holloway, K., Flynn, G., Lancashire, C. L., Loughlin, J., Male, D. K., & Romero, I. A. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.029 · Cited by 118 · see citing works
Guedes, J. R., Lao, T., Cardoso, A. L., & El Khoury, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00549 · Cited by 115 · see citing works
Miles, E. A., Rees, D., Banerjee, T., Cazzola, R., Lewis, S., Wood, R., Oates, R., Tallant, A., Cestaro, B., Yaqoob, P., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.002 · Cited by 112 · see citing works
Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia
Biber, K. P. H., Dijkstra, I. M., Trebst, C., Groot, C. J. A. D., Ransohoff, R. M., & Boddeke, H. W. G. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00114-8 · Cited by 111 · see citing works
Xia, M., & Hyman, B. T. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00463-5 · Cited by 105 · see citing works
Self-citationChemokines in the brain: neuroimmunology and beyond
Biber, K. P. H. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00122-9 · Cited by 104 · see citing works
Gimsa, U., Mitchison, N. A., & Brunner-Weinzierl, M. C. (2013) · Mediators of Inflammation · doi:10.1155/2013/320519 · Cited by 100 · see citing works
Ko, E. M., Ma, J. H., Guo, F., Miers, L. A., Lee, E., Bannerman, P. G. C., Burns, T., Ko, D., Sohn, J., Soulika, A. M., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-105 · Cited by 99 · see citing works
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization
Salvi, V., Sozio, F., Sozzani, S., & Prete, A. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00148 · Cited by 99 · see citing works
Grzanna, R., Phan, P. V., Polotsky, A., Lindmark, L., & Frondoza, C. G. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2004.10.1009 · Cited by 98 · see citing works
Role of interleukin-1 in prion disease-associated astrocyte activation.
Schultz, J., Schwarz, A., Neidhold, S., Burwinkel, M., Riemer, C., Simon, D., Kopf, M., Otto, M., & Baier, M. (2004) · American Journal of Pathology · doi:10.1016/s0002-9440(10)63331-7 · Cited by 101 · see citing works
Role of Chemokines in the Development and Progression of Alzheimer’s Disease
Wojcieszak, J., Kuczyńska, K., & Zawilska, J. B. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02047-1 · Cited by 97 · see citing works
Banas, B., Wörnle, M., Berger, T., Nelson, P. J., Cohen, C. D., Kretzler, M., Pfirstinger, J., Mack, M., Lipp, M., Gröne, H., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4301 · Cited by 95 · see citing works
Cross-talk between microglia and neurons regulates HIV latency
Alvarez-Carbonell, D., Ye, F., Ramanath, N., García‐Mesa, Y., Knapp, P. E., Hauser, K. F., & Karn, J. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008249 · Cited by 93 · see citing works
Chemokines and Alzheimer's disease
Streit, W. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00290-1 · Cited by 94 · see citing works
Glaser, J., González, R., Sadr, E., & Keirstead, H. S. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20982 · Cited by 93 · see citing works
Overexpression of IFN-Induced Protein 10 and Its Receptor CXCR3 in Myasthenia Gravis
Feferman, T., Maiti, P. K., Berrih‐Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., & Souroujon, M. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5324 · Cited by 92 · see citing works
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Doron, H., Pukrop, T., & Erez, N. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1805 · Cited by 92 · see citing works
Cerebrospinal fluid interferon-γ-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection
Cinque, P. M., Bestetti, A., Marenzi, R., Sala, S., Gisslén, M., Hagberg, L., & Price, R. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.07.002 · Cited by 89 · see citing works
Westhoff, D., Witlox, J., Koenderman, L., Kalisvaart, K. J., de Jonghe, J. F. M., van Stijn, M. F. M., Houdijk, A. P. J., Hoogland, I. C. M., MacLullich, A. M. J., van Westerloo, D. J., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-122 · Cited by 90 · see citing works
Carr, D. J. J., Chodosh, J., Ash, J. D., & Lane, T. E. (2003) · Journal of Virology · doi:10.1128/jvi.77.18.10037-10046.2003 · Cited by 90 · see citing works
Watson, K., & Fan, G.-H. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.004812 · Cited by 88 · see citing works
TNF-α-induced chemokine production and apoptosis in human neural precursor cells
Sheng, W. S., Hu, S., Ni, H. T., Rowen, T. N., Lokensgard, J. R., & Peterson, P. K. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405221 · Cited by 86 · see citing works
Nelson, T. E., & Gruol, D. L. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.07.009 · Cited by 84 · see citing works
Decreased Fractalkine and Increased IP-10 Expression in Aged Brain of APPswe Transgenic Mice
Duan, R., Yang, X., Chen, Z., Lu, M., Morris, C. M., Winblad, B. G., & Zhu, J. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9554-z · Cited by 82 · see citing works
Satish, L., Blair, H. C., Glading, A., & Wells, A. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1922-1941.2005 · Cited by 81 · see citing works
Phares, T. W., Stohlman, S. A., Hinton, D. R., & Bergmann, C. C. (2013) · Journal of Virology · doi:10.1128/jvi.03307-12 · Cited by 79 · see citing works
Antonelli, A., Ferrari, S. M., Frascerra, S., Galetta, F., Franzoni, F., Corrado, A., Miccoli, M., Benvenga, S., Paolicchi, A., Ferrannini, E., et al. (2011) · Cytokine · doi:10.1016/j.cyto.2011.04.022 · Cited by 75 · see citing works
Cheng, Z., Qiu, S., Jiang, L., Zhang, A., Bao, W., Liu, P., & Liu, J. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9834-5 · Cited by 73 · see citing works
Boztuǧ, K., Carson, M. J., Pham-Mitchell, N., Asensio, V. C., DeMartino, J. A., & Campbell, I. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1505 · Cited by 71 · see citing works
A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines
Zhao, Q., Kim, T., Pang, J., Sun, W. Y., Yang, X., Wang, J., Song, Y., Zhang, H., Sun, H., Rangan, V. S., et al. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a0717-302 · Cited by 71 · see citing works
Role of CXCL10 in central nervous system inflammation
McKimmie, C. S., & Michlmayr, D. (2014) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s35953 · Cited by 70 · see citing works
Psenicka, M. W., Smith, B. C., Tinkey, R. A., & Williams, J. L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.654284 · Cited by 69 · see citing works
Viejo, L., Noori, A., Merrill, E., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12753 · Cited by 69 · see citing works
Self-citationCXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice
Kong, Y.-F., Sha, W., Wu, X., Zhao, L., Ma, L.-J., & Gao, Y. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00608-1 · Cited by 68 · see citing works
Sankar, S. B., Pybus, A. F., Liew, A. Y., Sanders, B., Shah, K. J., Wood, L. B., & Buckley, E. M. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.12.018 · Cited by 65 · see citing works
O’Sullivan, J. B., Ryan, K. M., Harkin, A., & Connor, T. J. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.12.007 · Cited by 66 · see citing works
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
Bradburn, S., McPhee, J. S., Bagley, L., Carroll, M. A., SLEVIN, M. A., Al‐Shanti, N., Barnouin, Y., Hogrel, J., Pääsuke, M., Gapeyeva, H., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.11.009 · Cited by 66 · see citing works
Zaheer, A., Zaheer, S. A., Thangavel, R., Wu, Y., Sahu, S. K., & Yang, B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.093 · Cited by 65 · see citing works
Wu, J., Bie, B., Yang, H., Xu, J. J., Brown, D. L., & Naguib, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.003 · Cited by 62 · see citing works
Ragozzino, D. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100932 · Cited by 62 · see citing works
The Role of CXCR3 in Neurological Diseases
Zhou, Y., Liu, D.-Q., Chen, S., Sun, J., Zhou, X.-R., Xing, C., Ye, D., & Tian, Y. (2019) · Current Neuropharmacology · doi:10.2174/1570159x15666171109161140 · Cited by 62 · see citing works
Haddad, J. J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.002 · Cited by 61 · see citing works
Lynch, M. A. (2014) · Immunology · doi:10.1111/imm.12156 · Cited by 64 · see citing works
Chemokines in Alzheimer’s Disease: New Insights Into Prokineticins, Chemokine-Like Proteins
Zuena, A. R., Casolini, P., Lattanzi, R., & Maftei, D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00622 · Cited by 60 · see citing works
Guzmán, B. C., Chaffey, T. E., Palpagama, T. H., Waters, S., Boix, J., Tate, W. P., Peppercorn, K., Dragunow, M., Waldvogel, H. J., Faull, R. L. M., et al. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.552073 · Cited by 59 · see citing works
van Weering, H. R. J., Boddeke, H. W. G. M., Vinet, J., Brouwer, N., Haas, A. H. D., van Rooijen, N., Thomsen, A. R., & Biber, K. P. H. (2010) · Hippocampus · doi:10.1002/hipo.20742 · Cited by 59 · see citing works
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease
Sushma, & Mondal, A. C. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103414 · Cited by 56 · see citing works
Chemokine Receptors and Neural Function
Cho, C., & Miller, R. J. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290101003 · Cited by 59 · see citing works
Karahan, H., Smith, D. C., Kim, B., Dabin, L. C., Al-Amin, M. M., Wijeratne, H. R. S., Pennington, T., Viana di Prisco, G., McCord, B., Lin, P. B.-C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe3954 · Cited by 53 · see citing works
CCR5 deficiency induces astrocyte activation, Aβ deposit and impaired memory function
Lee, Y. K., Kwak, D. H., Oh, K. W., Nam, S.-Y., Lee, B. J., Yun, Y. W., Kim, Y.-B., Han, S., & Hong, J. T. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.04.003 · Cited by 58 · see citing works
Immunopathogenesis of HIV-associated dementia
Wesselingh, S. L., & Thompson, K. A. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200106000-00018 · Cited by 58 · see citing works
Alpha-chemokine receptors CXCR1–3 and their ligands in idiopathic inflammatory myopathies
Paepe, B. D., Keyzer, K. D., Martin, J., & Bleecker, J. D. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-0989-5 · Cited by 58 · see citing works
Vlkolinský, R., Siggins, G. R., Campbell, I. L., & Krucker, T. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.011 · Cited by 57 · see citing works
Chronic CXCL10 alters neuronal properties in rat hippocampal culture
Cho, J., Nelson, T. E., Bajova, H., & Gruol, D. L. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.007 · Cited by 56 · see citing works
- Authors
- Xia, M. Q., Bacskai, B. J., Knowles, R. B., Qin, S. X., & Hyman, B. T.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 108
- Issue
- 1-2
- Pages
- 227-235
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2002670780
- Cited by
- 269
- References
- 55
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 15 · 2023: 16 · 2022: 14 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 3 · 2015: 4 · 2014: 11 · 2013: 13 · 2012: 4
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50 AG05134, P50AG005134)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- CXCR3, CXCL10, CCL22, MIP-1β, Alzheimer's disease, reactive astrocytes, neurons, ERK1/2 activation, neuron-glia interactions, amyloid plaques, chemokines, neuroinflammation, cortical neurons
- MeSH terms
- Aged, Alzheimer Disease, Animals, Astrocytes, Cells, Cultured, Cerebral Cortex, Enzyme Activation, Female, Glial Fibrillary Acidic Protein, Humans, Ligands, Neurons, Phosphorylation, Up-Regulation, Macrophage Inflammatory Proteins, Receptors, Chemokine, Chemokines, CXC, Gene Expression Profiling, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Intercellular Signaling Peptides and Proteins, Mice, Chemokine CXCL10, Receptors, CXCR3, Chemokine CXCL9, Chemokine CCL4, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review