The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Recent endemic coronavirus infection is associated with less severe COVID-19
Open accessAbstract
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.
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“Epidemiological evidence from a large cohort now supports the possibility of some degree of pre-existing immunity (Sagar et al., 2021).”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Sagar et al., 2021
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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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Research works printed but not linked: 1
- 10.1016/j.medj.2020.05 · DOI
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Adaptive immunity to SARS-CoV-2 and COVID-19
Sette, A., & Crotty, S. (2021) · Cell · doi:10.1016/j.cell.2021.01.007 · Cited by 1,860
The T cell immune response against SARS-CoV-2
Moss, P. A. H. (2022) · Nature Immunology · doi:10.1038/s41590-021-01122-w · Cited by 1,243
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
Swadling, L., Diniz, M. O., Schmidt, N. M., Amin, O. E., Chandran, A., Shaw, E., Pade, C., Gibbons, J. M., Bert, N. L., Tan, A. T., et al. (2021) · Nature · doi:10.1038/s41586-021-04186-8 · Cited by 398
Anderson, E. M., Goodwin, E. C., Verma, A., Arevalo, C. P., Bolton, M. J., Weirick, M. E., Gouma, S., McAllister, C. M., Christensen, S. R., Weaver, J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.010 · Cited by 381
Metadata
- Authors
- Sagar, M., Reifler, K., Rossi, M., Miller, N. S., Sinha, P., White, L. F., & Mizgerd, J. P.
- Affiliations
- Boston University (US)
- Corresponding author
- Sagar, Manish
- Mizgerd, Joseph P.
- Venue
- Journal of Clinical Investigation
- Published
- 2021-01-04
- Volume
- 131
- Issue
- 1
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7773342
- OpenAlex
- W3090049663
- Cited by
- 324
- References
- 20
- Citations by year
- 2026: 13 · 2025: 28 · 2024: 32 · 2023: 59 · 2022: 77 · 2021: 109
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL-135756, AI-145661, AI-052074, GM-122876)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- endemic coronaviruses, SARS-CoV-2, COVID-19 severity, pre-existing immunity, cross-protection, common cold, immune response
- MeSH terms
- COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Female, Humans, Male, Middle Aged, Severity of Illness Index
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