Burst-like control of lipolysis by the sympathetic nervous system in vivo

Hücking, Katrin; Hamilton-Wessler, Marianthe; Ellmerer, Martin; Bergman, Richard N.

doi:10.1172/jci14466

Cited by 89Lipid metabolism and biosynthesisAdipose Tissue and MetabolismLipid metabolism and disorders

Burst-like control of lipolysis by the sympathetic nervous system in vivo

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Hücking, Katrin, Hamilton-Wessler, Marianthe, Ellmerer, Martin, Bergman, Richard N.·2003·Journal of Clinical Investigation

DOI 10.1172/jci14466PMC PMC151855

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Abstract

Rapid oscillations of visceral lipolysis have been reported. To examine the putative role of the CNS in oscillatory lipolysis, we tested the effects of beta(3)-blockade on pulsatile release of FFAs. Arterial blood samples were drawn at 1-minute intervals for 120 minutes from fasted, conscious dogs (n = 7) during the infusion of saline or bupranolol (1.5 micro g/kg/min), a high-affinity beta(3)-blocker. FFA and glycerol time series were analyzed and deconvolution analysis was applied to estimate the rate of FFA release. During saline infusion FFAs and glycerol oscillated in phase at about eight pulses/hour. Deconvolution analysis showed bursts of lipolysis (nine pulses/hour) with time-dependent variation in burst frequency. Bupranolol completely removed rapid FFA and glycerol oscillations. Despite removal of lipolytic bursts, plasma FFAs (0.31 mM) and glycerol (0.06 mM) were not totally suppressed and deconvolution analysis revealed persistent non-oscillatory lipolysis (0.064 mM/min). These results show that lipolysis in the fasting state consists of an oscillatory component, which appears to be entirely dependent upon sympathetic innervation of the adipose tissue, and a non-oscillatory, constitutive component, which persists despite beta(3)-blockade. The extinction of lipid fuel bursts by beta(3)-blockade implies a role for the CNS in the maintenance of cyclic provision of lipid fuels.

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Exogenous administration of cortisol or norepinephrine induces total body and cellular insulin resistance.
“Indeed, exogenous administration of cortisol or norepinephrine, 2 hormones that are hypersecreted when the hypothalamic–pituitary–adrenal axis and sympathetic nervous system are respectively activated, has been shown to induce total body (36–38) and cellular (39) insulin resistance.”
From Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study (2012) · cites this paper as [39]
The Discussion links free-fatty-acid bursts to possible obesity-related insulin resistance, but does not report that administering cortisol or norepinephrine induces insulin resistance. Searches for cortisol, norepinephrine administration, and insulin resistance found no passage establishing the claimed whole-body or cellular effect. (LLM, conf=0.76)
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Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Metabolic Implications of Body Fat Distribution
Björntorp, P. A. (1991) · Diabetes Care · doi:10.2337/diacare.14.12.1132 · Cited by 1,056 · see citing works
Receptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979 · see citing works
Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection
Veldhuis, J. D., & Johnson, M. L. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.4.e486 · Cited by 855 · see citing works
New insights into sympathetic regulation of glucose and fat metabolism
Nonogaki, K. (2000) · Diabetologia · doi:10.1007/s001250051341 · Cited by 576 · see citing works
The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.
Veldhuis, J. D., Carlson, M. L., & Johnson, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7686 · Cited by 556 · see citing works
In vivo regulation of lipolysis in humans.
Coppack, S. W., Jensen, M. D., & Miles, J. M. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41207-6 · Cited by 403 · see citing works
Absence of Low-Frequency Variability of Sympathetic Nerve Activity in Severe Heart Failure
van de Borne, P., Montano, N., Pagani, M., Oren, R. M., & Somers, V. K. (1997) · Circulation · doi:10.1161/01.cir.95.6.1449 · Cited by 376 · see citing works
Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue
Bamshad, M., Aoki, V. T., Adkison, M., Warren, W. S., & Bartness, T. J. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r291 · Cited by 344 · see citing works
Thyroid and lipid metabolism
Pucci, E., Chiovato, L., & Pinchera, A. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801292 · Cited by 342 · see citing works
Regulation of plasma free fatty acid turnover
Armstrong, D. T., Steele, R., ALTSZULER, N., Dunn, A., Bishop, J. S., & de Bodo, R. C. (1961) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1961.201.1.9 · Cited by 331 · see citing works
Model for the regulation of energy balance and adiposity by the central nervous system
Schwartz, M. W., Baskin, D. G., Kaiyala, K. J., & Woods, S. C. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.4.584 · Cited by 323 · see citing works
Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.
Rebrin, K., Steil, G. M., Mittelman, S. D., & Bergman, R. N. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118846 · Cited by 288 · see citing works
Self-citation
Innervation of mammalian white adipose tissue: implications for the regulation of total body fat
Bartness, T. J., & Bamshad, M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1399 · Cited by 285 · see citing works
Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin
Rebrin, K., Steil, G. M., Getty‐Kaushik, L., & Bergman, R. N. (1995) · Diabetes · doi:10.2337/diab.44.9.1038 · Cited by 270 · see citing works
Self-citation
The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin
Kim, M. S., Small, C. J., Stanley, S. A., Morgan, D. G. A., Seal, L. J., Kong, W. M., Edwards, C. M. B., Abusnana, S., Sunter, D., Ghatei, M. A., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8857 · Cited by 256 · see citing works
Ba2+ inhibition of VIP- and A23187-stimulated Cl- secretion by T84 cell monolayers
Mandel, K. G., McRoberts, J. A., Beuerlein, G., Foster, E. S., & Dharmsathaphorn, K. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.3.c486 · Cited by 251 · see citing works
STRUCTURE AND FUNCTION OF THE β3-ADRENERGIC RECEPTOR
Strosberg, A. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.421 · Cited by 250 · see citing works
The -Adrenergic Receptors and the Control of Adipose Tissue Metabolism and Thermogenesis
Collins, S. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.309 · Cited by 249 · see citing works
Central Role of the Adipocyte in the Metabolic Syndrome
Bergman, R. N., Van Citters, G. W., Mittelman, S. D., Dea, M. K., Hamilton-Wessler, M., Kim, S. P., & Ellmerer, M. (2001) · Journal of Investigative Medicine · doi:10.2310/6650.2001.34108 · Cited by 202 · see citing works
Self-citation
Are Increased Plasma Non-Esterified Fatty Acid Concentrations a Risk Marker for Coronary Heart Disease and other Chronic Diseases?
Frayn, K. N., Williams, C. M., & Arner, P. (1996) · Clinical Science · doi:10.1042/cs0900243 · Cited by 201 · see citing works
Estimating false-positive and false-negative errors in analyses of hormonal pulsatility
Cauter, E. V. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.6.e786 · Cited by 177 · see citing works
Validation of a new method for determination of free fatty acid turnover
Miles, J. M., Ellman, M., McClean, K. L., & Jensen, M. D. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.3.e431 · Cited by 161 · see citing works
Free Fatty Acids—The Link Between Obesity and Insulin Resistance
Boden, G. H. (2001) · Endocrine Practice · doi:10.4158/ep.7.1.44 · Cited by 154 · see citing works
Analysis of techniques to obtain plasma for measurement of levels of free fatty acids
Zambon, A., Hashimoto, S., & Brunzell, J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39687-5 · Cited by 143 · see citing works
Kinetic studies of plasma free fatty acid and triglyceride metabolism in man
Eaton, R. P., Berman, M., & Steinberg, D. H. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106122 · Cited by 133 · see citing works
Removal and mobilization of individual free fatty acids in dogs
Miller, H. I., Gold, M., & Spitzer, J. J. (1962) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1962.202.2.370 · Cited by 126 · see citing works
Energy Metabolism in Feasting and Fasting
Owen, O. E., Reichard, G., Patel, M. S., & Boden, G. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0734-2_8 · Cited by 116 · see citing works
Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo
Coppack, S. W., Persson, M., Judd, R. L., & Miles, J. M. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.2.e233 · Cited by 103 · see citing works
Lipolytic response to glucose infusion in human subjects
Wolfe, R. R., & Peters, E. J. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.2.e218 · Cited by 101 · see citing works
Mechanism of free fatty acid re-esterification in human adipocytes in vitro.
Edens, N. K., Leibel, R., & Hirsch, J. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42613-6 · Cited by 99 · see citing works
Role of β1- and β3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes
Atgié, C., Dallaire, F., & Bukowiecki, L. J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1136 · Cited by 98 · see citing works
New model for the regulation of energy balance and adiposity by the central nervous system
Kaiyala, K., Woods, S. C., & Schwartz, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.5.1123s · Cited by 98 · see citing works
Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion.
Carpéné, C., Galitzky, J., Collon, P., Esclapez, F., Dauzats, M., & Lafontan, M. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38092-4 · Cited by 92 · see citing works
Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat
Shi, H., & Bartness, T. J. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00455-x · Cited by 83 · see citing works
Evolution of Deconvolution Analysis as a Hormone Pulse Detection Method
Johnson, M. L., & Veldhuis, J. D. (1995) · Methods in neurosciences · doi:10.1016/s1043-9471(06)80027-3 · Cited by 72 · see citing works
STRUCTURE AND FUNCTION OF THE 3 -ADRENERGIC RECEPTOR
Strosberg, A. D. (1997) · Cited by 68 · see citing works
Regulation of lipid metabolism in adipose tissue during early starvation
Samra, J. S., Clark, M. L., Humphreys, S. M., Macdonald, I. A., & Frayn, K. N. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e541 · Cited by 68 · see citing works
Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions
Dunbar, J. C., & Lu, H. (2000) · Peptides · doi:10.1016/s0196-9781(99)00192-8 · Cited by 67 · see citing works
Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS
van Dam, E. W. C. M., Roelfsema, F., Veldhuis, J. D., Helmerhorst, F. M., Frölich, M., Meinders, A. E., Krans, H. M. J., & Pijl, H. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00458.2001 · Cited by 63 · see citing works
Role of GH in regulating nocturnal rates of lipolysis and plasma mevalonate levels in normal and diabetic humans
Boyle, P. J., Avogaro, A., Smith, L., Bier, D. M., Pappu, A. S., Illingworth, D. R., & Cryer, P. E. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.1.e168 · Cited by 54 · see citing works
Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo
Getty‐Kaushik, L., Panteleon, A. E., Mittelman, S. D., Dea, M. K., & Bergman, R. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7815 · Cited by 52 · see citing works
Self-citation
Alterations in adipocyte free fatty acid re-esterification associated with obesity and weight reduction in man
Leibel, R. L., Hirsch, J., Berry, E., & Gruen, R. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.2.198 · Cited by 47 · see citing works
Detection of low- and high-frequency rhythms in the variability of skin sympathetic nerve activity
Cogliati, C. B., Magatelli, R., Montano, N., Narkiewicz, K., & Somers, V. K. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.4.h1256 · Cited by 42 · see citing works
Regional glycerol and free fatty acid metabolism before and after meal ingestion
Jensen, M. D. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e863 · Cited by 39 · see citing works
Interrelationship of FFA and glycerol turnovers in resting and exercising dogs
Shaw, W. A., Issekutz, T. B., & Issekutz, B., Jr. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.39.1.30 · Cited by 38 · see citing works
Coexistence of beta 1-, beta 2-, and beta 3-adrenoceptors in dog fat cells and their differential activation by catecholamines
Galitzky, J., Reverte, M., Portillo, M. P., Carpéné, C., Lafontan, M., & Berlan, M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.3.e403 · Cited by 32 · see citing works
Regulation of fatty acid delivery in vivo.
Frayn, K. (1998) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4899-1928-1_16 · Cited by 30 · see citing works
Mechanism of the lipid-mobilizing effect of alpha-2 adrenergic antagonists in the dog.
Taouis, M., Berlan, M., Montastruc, P., & Lafontan, M. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13275-8 · Cited by 25 · see citing works
Effects of Fasting on Physiologically Pulsatile Insulin Release in Healthy Humans
Juhl, C. B., Grøfte, T., Butler, P. C., Veldhuis, J. D., Schmitz, O., & Pørksen, N. K. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s255 · Cited by 25 · see citing works
GH Secretion Is Impaired in Patients with Primary Hyperparathyroidism
Gasperi, M., Cecconi, E., Grasso, L., Bartalena, L., Centoni, R., Aimaretti, G., Broglio, F., Miccoli, P., Marcocci, C., Ghigo, E., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8451 · Cited by 24 · see citing works
Participation of the CNS in the control of FFA mobilization during fasting in rabbits
Paschoalini, M. A., & Migliorini, R. H. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90109-h · Cited by 19 · see citing works
Effect of electrical stimulation of the hypothalamus on plasma free fatty acid concentration in cats
Barkai, A., & Allweis, C. L. (1972) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39342-1 · Cited by 17 · see citing works
Postganglionic sympathetic nerve discharges can contain both central and pulse-related oscillations simultaneously in rabbits
Ando, S., Imaizumi, T., Harada, S., Suzuki, S. O., Sugimachi, M., Sunagawa, K., Hirooka, Y., & Takeshita, A. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90180-5 · Cited by 4 · see citing works
Measurement of free fatty acid kinetics during non‐equilibrium tracer conditions in man: implications for the estimation of the rate of appearance of free fatty acids
Riemens, S., Dullaart, R., Franssen, E., Piers, D., Reitsma, W., & Sluiter, W. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00249.x · Cited by 4 · see citing works
Sugar-beet Seed
Cockerell, T. D. A. (1920) · Nature · doi:10.1038/104661a0 · Cited by 1 · see citing works
Untitled work
Kuzawa, C. W. (1998) · doi:10.1002/(sici)1096-8644(1998)107:27+

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Frayn, K. N., Karpe, F., Fielding, B. A., Macdonald, I. A., & Coppack, S. W. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802326 · Cited by 467 · see citing works
Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study
Broussard, J. L., Ehrmann, D. A., Van Cauter, E., Tasali, E., & Brady, M. J. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-8-201210160-00005 · Cited by 364 · see citing works
“Changes in sympathetic nervous system activity are readily transmitted to adipose tissue by means of direct innervation (40), whereas increases in circulating cortisol and norepinephrine levels result in increased binding to specific cellular receptors (41, 42).”
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Arnardóttir, E. S., Mackiewicz, M., Gíslason, Þ., Teff, K. L., & Pack, A. I. (2009) · SLEEP · doi:10.1093/sleep/32.4.447 · Cited by 347 · see citing works
Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes
Reutrakul, S., & Van Cauter, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12355 · Cited by 321 · see citing works
Abdominal Obesity: Role in the Pathophysiology of Metabolic Disease and Cardiovascular Risk
Bergman, R. N., Kim, S. P., Hsu, I. R., Catalano, K. J., Chiu, J. D., Kabir, M., Richey, J. M., & Ader, M. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.11.012 · Cited by 287 · see citing works
Self-citation
Lipolysis and the integrated physiology of lipid energy metabolism
Wang, S., Soni, K. G., Semache, M., Casavant, S., Fortier, M., Pan, L., & Mitchell, G. A. (2008) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2008.06.012 · Cited by 169 · see citing works
Metabolic syndrome, hyperinsulinemia, and cancer
Hsu, I. R., Kim, S. P., Kabir, M., & Bergman, R. N. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.867s · Cited by 159 · see citing works
Self-citation
Direct Stimulation of Ghrelin Secretion by Sympathetic Nerves
Mundinger, T. O., Cummings, D. E., & Taborsky, G. J. (2006) · Endocrinology · doi:10.1210/en.2005-1182 · Cited by 153 · see citing works
Continuous Positive Airway Pressure Reduces Postprandial Lipidemia in Obstructive Sleep Apnea: A Randomized, Placebo-Controlled Crossover Trial
Phillips, C. L., Yee, B. J., Marshall, N. S., Liu, P. Y., Sullivan, D. R., & Grunstein, R. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201102-0316oc · Cited by 145 · see citing works
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 137 · see citing works
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Larcher, S., Benhamou, P., Pépin, J., & Borel, A. (2015) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.12.004 · Cited by 134 · see citing works
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Wang, Y., Tang, Y., He, Z., Ma, H., Wang, L., Liu, Y., Yang, Q., Pan, D., Zhu, C., Qian, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00482-9 · Cited by 132 · see citing works
Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis
Albaugh, V. L., Judson, J., She, P., Lang, C. H., Maresca, K. P., Joyal, J. L., & Lynch, C. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.33 · Cited by 114 · see citing works
Orchestration of Glucose Homeostasis
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Self-citation
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Kawahara, Y., Grimberg, A., Teegarden, S., Mombereau, C., Liu, S., Bale, T. L., Blendy, J. A., & Nishikura, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3896-08.2008 · Cited by 105 · see citing works
Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men
Robertson, M. D., Russell-Jones, D., Umpleby, A. M., & Dijk, D.-J. (2013) · Metabolism · doi:10.1016/j.metabol.2012.07.016 · Cited by 100 · see citing works
Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
Song, S. O., He, K., Narla, R. R., Kang, H. G., Ryu, H. U., & Boyko, E. J. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0256 · Cited by 101 · see citing works
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Self-citation
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Oben, J. A., Roskams, T., Yang, S., Lin, H., Sinelli, N., Li, Z., Torbenson, M. S., THOMAS, S. A., & Diehl, A. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01360-3 · Cited by 68 · see citing works
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Blouet, C., & Schwartz, G. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6498-10.2011 · Cited by 53 · see citing works
Mitochondrial DNA alteration in obstructive sleep apnea
Lacedonia, D., Carpagnano, G. E., Crisetti, E., Cotugno, G., Palladino, G. P., Patricelli, G., Sabato, R., & Barbaro, M. P. F. (2015) · Respiratory Research · doi:10.1186/s12931-015-0205-7 · Cited by 54 · see citing works
Adipose tissue fatty acid metabolism and cardiovascular disease
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Chow, C. C., Periwal, V., Csako, G., Ricks, M., Courville, A. B., Miller, B. V., Vega, G. L., & Sumner, A. E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0532 · Cited by 50 · see citing works
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Blouet, C., Liu, S., Jo, Y., Chua, S. C., & Schwartz, G. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-12.2012 · Cited by 48 · see citing works
GH Does Not Modulate the Early Fasting-Induced Release of Free Fatty Acids in Mice
Steyn, F. J., Leong, J. W., Huang, L., Tan, H. Y., Xie, T. Y., Nelson, C., Waters, M. J., Veldhuis, J. D., Epelbaum, J., & Chen, C. (2012) · Endocrinology · doi:10.1210/en.2011-1681 · Cited by 44 · see citing works
Clock genes and sleep
Landgraf, D., Shostak, A., & Oster, H. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1003-9 · Cited by 43 · see citing works
Androgens, Obesity, and Sleep-Disordered Breathing in Men
Liu, P. Y., Caterson, I. D., Grunstein, R. R., & Handelsman, D. J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.002 · Cited by 43 · see citing works
Beyond Feast–Famine: Brain Evolution, Human Life History, and the Metabolic Syndrome
Kuzawa, C. W. (2010) · Human Evolutionary Biology · doi:10.1017/cbo9780511781193.037 · Cited by 39 · see citing works
Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes
Mahmood, W. A. W., Draman, M. S., Behan, L., Perna, A., Tun, T. K., McDermott, J., & Sreenan, S. (2013) · International Journal of Endocrinology · doi:10.1155/2013/341506 · Cited by 38 · see citing works
Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia
Wang, M., Wang, Q., & Whim, M. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517275113 · Cited by 36 · see citing works
Beneficial effects of weekend catch-up sleep on metabolic syndrome in chronic short sleepers
Kim, D. J., Mun, S. J., Choi, J. S., Kim, J., Lee, G.-H., Kim, H.-W., Park, M., & Cho, J. W. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.09.025 · Cited by 33 · see citing works
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., & Challet, É. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00009-3 · Cited by 32 · see citing works
SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity
Deng, Y., Xiao, Y., Yuan, F., Liu, Y., Jiang, X., Deng, J., Fejes‐Tóth, G., Náray‐Fejes‐Tóth, A., Chen, S., Chen, Y., et al. (2018) · Diabetes · doi:10.2337/db17-1069 · Cited by 31 · see citing works
Free Fatty Acid Regulation of Glucose-Dependent Intrinsic Oscillatory Lipolysis in Perifused Isolated Rat Adipocytes
Getty‐Kaushik, L., Richard, A.-M. T., & Corkey, B. E. (2005) · Diabetes · doi:10.2337/diabetes.54.3.629 · Cited by 30 · see citing works
Shengmai San formula alleviates high-fat diet-induced obesity in mice through gut microbiota-derived bile acid promotion of M2 macrophage polarization and thermogenesis
Wang, Z., Wang, X., Fu, L., Xu, S., Wang, X., Liao, Q., Zhuang, T., Liu, L., Zhang, H., Li, W., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155938 · Cited by 27 · see citing works
Oscillations of Fatty Acid and Glycerol Release From Human Subcutaneous Adipose Tissue In Vivo
Karpe, F., Fielding, B. A., Coppack, S. W., Lawrence, V., Macdonald, I. A., & Frayn, K. N. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1297 · Cited by 26 · see citing works
Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice
Chen, D., Qi, Y., Zhang, J., & Yang, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-35258-6 · Cited by 25 · see citing works
Neurohumoral stimulation in type-2-diabetes as an emerging disease concept
Pliquett, R., Faßhauer, M., Blüher, M., & Paschke, R. (2004) · Cardiovascular Diabetology · doi:10.1186/1475-2840-3-4 · Cited by 25 · see citing works
Effect of Endothelin‐1 on Lipolysis in Rat Adipocytes
Juan, C., Chang, L., Huang, S., Chang, C., Lee, C., Chien, Y., Hsu, Y.-P., Ho, P., Chen, Y., & Ho, L. (2006) · Obesity · doi:10.1038/oby.2006.53 · Cited by 24 · see citing works
How type of parturition and health status influence hormonal and metabolic profiles in newborn foals
Panzani, S., Comin, A., Galeati, G., Romano, G., de Ruijter‐Villani, M., Faustini, M., & Veronesi, M. C. (2011) · Theriogenology · doi:10.1016/j.theriogenology.2011.10.023 · Cited by 23 · see citing works
Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze
Sharma, V. S. (2011) · World Journal of Cardiology · doi:10.4330/wjc.v3.i9.281 · Cited by 22 · see citing works
The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension
Eikelis, N., Hering, D., Marušić, P., Duval, J., Hammond, L. J., Walton, A., Lambert, É., Esler, M., Lambert, G. W., & Schlaich, M. P. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00369 · Cited by 18 · see citing works
PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure
Tang, G., Ma, C., Li, L., Zhang, S., Li, F., Wu, J., Yin, Y., Zhu, Q. S., Liang, Y., Wang, R., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2157-y · Cited by 17 · see citing works
The GLP-1 Receptor Agonist Dulaglutide Attenuates Hepatic Steatosis in Obesity via a Weight-Independent Mechanism
Shantaram, D., Rima, X. Y., Bradley, D. P., Liu, J. Z., Wright, V. P., AMARI, A., Jalilvand, A., Rottinghaus, J., Fernandes, J. M., Smith, A. J., et al. (2025) · Diabetes · doi:10.2337/db24-0861 · Cited by 16 · see citing works
Obstructive sleep apnea and endothelial progenitor cells
Feng, J., Qing, W. A. N. G., Wu, Q., & Xin, S. U. N. (2013) · Patient Preference and Adherence · doi:10.2147/ppa.s51562 · Cited by 16 · see citing works
Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure
Xiao, Y., Xia, T., Yu, J., Deng, Y., Liu, H., Liu, B., Chen, S., Liu, Y., & Guo, F. (2016) · Open Biology · doi:10.1098/rsob.160131 · Cited by 16 · see citing works
Sleep characteristic profiles and the correlation with spectrum of metabolic syndrome among older adult: a cross-sectional study
Liu, X., Huang, L., Wu, Q., Chen, Y., Chen, X., Chen, H., Gao, J., & Xiao, Q. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03074-8 · Cited by 14 · see citing works
Intergenerational Memories of Past Nutritional Deprivation: The Phenotypic Inertia Model
Kuzawa, C. W., & Fried, R. L. (2017) · Springer eBooks · doi:10.1007/978-1-4939-4038-7_2 · Cited by 13 · see citing works
Glucose‐dependent Insulin Modulation of Oscillatory Lipolysis in Perifused Rat Adipocytes
Getty‐Kaushik, L., Richard, A.-M. T., & Corkey, B. E. (2005) · Obesity Research · doi:10.1038/oby.2005.255 · Cited by 13 · see citing works
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., Turek, F. W., & Cauter, E. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00011-3 · Cited by 14 · see citing works
Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-mediated Mechanism
Okada, A. K., Teranishi, K., Isas, J. M., Bedrood, S., Chow, R. H.-P., & Langen, R. (2016) · Scientific Reports · doi:10.1038/srep31094 · Cited by 11 · see citing works
Triacylglycerol metabolism in adipose tissue
Frayn, K. N., & Langin, D. (2003) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)33017-6 · Cited by 11 · see citing works
The 6th Annual World Congress on the Insulin Resistance Syndrome
Bloomgarden, Z. T. (2009) · Diabetes Care · doi:10.2337/dc09-zb09 · Cited by 11 · see citing works
Study of blood lipids, cortisol and haemodynamic variations under stress in male adults.
Qureshi, G. M., Seehar, G. M., Zardari, M. K., Pirzado, Z. A., & Abbasi, S. A. (2009) · PubMed · Cited by 11 · see citing works
Unraveling the complex roles of macrophages in obese adipose tissue: an overview
Peng, C. S., Chen, J., Wu, R., Jiang, H., & Li, J. X. (2024) · Frontiers of Medicine · doi:10.1007/s11684-023-1033-7 · Cited by 10 · see citing works
Metabolic disturbances: role of the circadian timing system and sleep
Adhikary, N., Shrestha, S. L., & Sun, J. Z. (2016) · Diabetology International · doi:10.1007/s13340-016-0279-6 · Cited by 10 · see citing works
Impact of Sleep and Circadian Disturbances on Glucose Metabolism and Type 2 Diabetes
Reutrakul, S., Punjabi, N. M., & Cauter, E. V. (2018) · Cited by 9 · see citing works
Unraveling the complex relationship between night shift work and diabetes: exploring mechanisms and potential interventions
Zhu, Y., & Mi, J. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1539679 · Cited by 8 · see citing works
Rhamnose Displays an Anti-Obesity Effect Through Stimulation of Adipose Dopamine Receptors and Thermogenesis
Lv, S., Hu, T., Zhang, R., Zhou, Y., Yu, W., Wang, Z., Shi, C., Lian, J.-J., Huang, S., Pei, G., et al. (2022) · Diabetes · doi:10.2337/db22-0552 · Cited by 8 · see citing works
TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner
Li, Y., Zhu, S., Du, D., Li, Q., Xie, K., Chen, L., Feng, X., Wu, X., Sun, Z., Zhou, J., et al. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100368 · Cited by 8 · see citing works
Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway
Wang, X., Wang, X., Yu, S., Huang, L., Xue, Q., Yang, X., Wang, Z., Lin, W., Jiang, Y., Xu, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67172-y · Cited by 7 · see citing works
The Etiology of Hypertension in the Metabolic Syndrome Part Two: The Gene-Environment Interaction
Publisher, B. S. P. B. S. (2006) · Current Vascular Pharmacology · doi:10.2174/157016106778521661 · Cited by 7 · see citing works
The benefits of hypoglycemic therapy for patients with obstructive sleep apnea
Lin, R., Yan, W., He, M., Liu, B., Su, X., Yi, M., & Zhang, Y. (2024) · Sleep And Breathing · doi:10.1007/s11325-024-03015-2 · Cited by 5 · see citing works
Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity
Zhang, W., Wang, S., Liu, Z., Qian, P., Li, Y., & Wu, J. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112283 · Cited by 5 · see citing works
Pulsatile changes in free fatty acids augment hepatic glucose production and preserves peripheral glucose homeostasis
Hsu, I. R., Zuniga, E. A., & Bergman, R. N. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2009 · Cited by 5 · see citing works
Self-citation
Fat Metabolism in Insulin Resistance and Type 2 Diabetes
Duez, H., & Lewis, G. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_4 · Cited by 4 · see citing works
Sleep health predicted glucose metabolism among pregnant women: A prospective cohort study
Wang, Y., Chen, P., Wang, J., Lin, Q., Hong, L., Izci‐Balserak, B., Yuan, J., Zhao, R., & Zhu, B. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111570 · Cited by 3 · see citing works
An unexpected role for the brain in the pathogenesis of diabetic ketoacidosis
Mirzadeh, Z., Morton, G. J., Hirsch, I. B., & Schwartz, M. W. (2025) · Journal of Clinical Investigation · doi:10.1172/jci196357 · Cited by 2 · see citing works
Deconvolution as a Novel Approach to Analyze Moment‐to‐Moment Free Fatty Acid Release
Hücking, K., Hsu, I. R., Ionut, V., & Bergman, R. N. (2007) · Obesity · doi:10.1038/oby.2007.287 · Cited by 2 · see citing works
Self-citation
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Shawer, G. A., Samaha, S. R., Khalifa, E.-E., & Abd-El-Monsef, A. S. (2016) · Al-Azhar Medical Journal · doi:10.12816/0033124 · Cited by 2 · see citing works
Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion
Moniruzzaman, M., Bezerra, A. B., Mohibullah, M., Judd, R. L., Granneman, J. G., & Easley, C. J. (2024) · Lab on a Chip · doi:10.1039/d4lc00664j · Cited by 1 · see citing works
Environmental Inputs, Intake of Nutrients, and Endogenous Molecules Contributing to the Regulation of Energy Homeostasis
Kelesidis, T., Kelesidis, I., & Mantzoros, C. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-453-1_3 · Cited by 1 · see citing works
Control of Weight: How Do We Get Fat?
Bray, G. A. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch8 · Cited by 1 · see citing works
Sleep, Energy Homeostasis and Metabolic Syndrome Alterations
Tsang, A. H. K., Husse, J., & Oster, H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5082-5_6
Role of Energy Expenditure in Regulation of Energy Homeostasis
Bachman, E. S. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_6
Aging, Carbohydrate Metabolism and the Autonomic Nervous System
Madden, K. M., & Meneilly, G. S. (2004) · KARGER eBooks · doi:10.1159/000077929
Pathogenesis of the metabolic syndrome and the influence of cannabinoids
Marzo, V. D., Kunos, G., Bergman, R. N., Després, J., & Brewer, B. (2008)
Self-citation
Health and Disease
Muehlenbein, M. P. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511781193.033
Molecular mechanisms underlying the effects of CB1 antagonism in canine model of obesity
Iyer, M. S. (2015) · University of Southern California Digital Library · doi:10.25549/usctheses-m2706
Regulation of adipocyte triglyceride storage
Karpe, F., & Tan, G. (2003) · CRC Press eBooks · doi:10.3109/9780203481165-16
Insulin receptor sensitization improves affective pathology in various mouse models
Nunes, J. P. D. C. A. V. (2015) · doi:10.26481/dis.20151221jc
Studies of adipose tissue in humans with special reference to innervation by the sympathetic nervous system
Lawrence, V. (2016)
Visceral adiposity syndrome and cardiometabolism
Lopes, H. F., & Egan, B. M. (2021) · Scripta Medica · doi:10.5937/scriptamed52-32717
References
(2011) · CRC Press eBooks · doi:10.1201/b10790-15
Faculty Opinions recommendation of Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.
Jockers, R., & Kamal, M. T. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1145166.602310
STUDY OF PHYSIOLOGICAL AND BIOCHEMICAL VARIATIONS IN POPULATION GROUPS UNDERGOING ACUTE OR CHRONIC STRESS
Kumar, A., Goru, B., KHAN, M. S. A., & Pathapati, R. (2024) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2024.v17i5.50450
Additional file 1 of Sleep characteristic profiles and the correlation with spectrum of metabolic syndrome among older adult: a cross-sectional study
Liu, X., Huang, L., Wu, Q., Chen, Y., Chen, X., Chen, H., Gao, J., & Xiao, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19753152

Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo
Getty‐Kaushik, L., Panteleon, A. E., Mittelman, S. D., Dea, M. K., & Bergman, R. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7815 · Cited by 52 · see citing works
Self-citation
Inhibition by β-hydroxybutyrate of lipolysis induced by sympathetic nerve activity in canine subcutaneous adipose tissue in situ
Fredholm, B. B. (1972) · Metabolism · doi:10.1016/0026-0495(72)90064-9 · Cited by 5 · see citing works
Effect of short- and long-term beta-adrenergic blockade on lipolysis during fasting in humans
Klein, S., Peters, E. J., Holland, O. B., & Wolfe, R. R. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.1.e65 · Cited by 76 · see citing works
The characterization of rapid oscillations in plasma free fatty acids and omental lipolysis: The role of insulin and the central nervous system.
Getty‐Kaushik, L. (2014) · University of Southern California Digital Library · doi:10.25549/usctheses-c17-575898
Adaptation to fasting in baboon. II. Regulation of lipolysis early and late in fasting
Koerker, D. J., Goodner, C. J., Chideckel, E. W., & Ensinck, J. W. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.229.2.350 · Cited by 22 · see citing works

Authors: Hücking, K., Hamilton-Wessler, M., Ellmerer, M., & Bergman, R. N.
Affiliations: University of Southern California (US)
Corresponding author: Bergman, Richard N.
ORCID: Bergman, Richard N.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2003-01-15
Volume: 111
Issue: 2
Pages: 257-264
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci14466
PMC: PMC151855
OpenAlex: W2068912594
Cited by: 89
References: 57
Citations by year: 2025: 4 · 2024: 7 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 4
FWCI: 2.37
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (DK27619)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027619, R01DK027619, R01DK029867, DK27619, DK29867)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: lipolysis, sympathetic nervous system, bupranolol, free fatty acids, glycerol, visceral adipose tissue, fasting state, central nervous system regulation, deconvolution
MeSH terms: Animals, Bupranolol, Dogs, Fasting, Fatty Acids, Nonesterified, Glycerol, Lipolysis, Male, Sympathetic Nervous System, Receptors, Adrenergic, beta-3

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Burst-like control of lipolysis by the sympathetic nervous system in vivo

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