The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Open accessAbstract
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this hormone in humans is limited. Three morbidly obese children, who were congenitally deficient in leptin, were treated with daily subcutaneous injections of recombinant human leptin for up to 4 years with sustained, beneficial effects on appetite, fat mass, hyperinsulinemia, and hyperlipidemia. Leptin therapy resulted in a rapid and sustained increase in plasma thyroid hormone levels and, through its age-dependent effects on gonadotropin secretion, facilitated appropriately timed pubertal development. Leptin deficiency was associated with reduced numbers of circulating CD4(+) T cells and impaired T cell proliferation and cytokine release, all of which were reversed by recombinant human leptin administration. The subcutaneous administration of recombinant human leptin has major and sustained beneficial effects on the multiple phenotypic abnormalities associated with congenital human leptin deficiency.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998
Self-citationLeptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · cited 1×
“This has been demonstrated recently by the sustained metabolic improvements seen with leptin therapy in human lipodystrophic disorders (39).”
BackgroundSelf-citationA leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158
Ozata, M., Ozdemir, I. C., & Licinio, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.5999 · Cited by 739
Rosenbaum, M., Murphy, E. M., Heymsfield, S. B., Matthews, D. E., & Leibel, R. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.2391 · Cited by 407
Harris, M., Aschkenasi, C., Elias, C. F., Chandrankunnel, A., Nillni, E. A., Bjørbæk, C., Elmquist, J. K., Flier, J. S., & Hollenberg, A. N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10741 · Cited by 341
Mantzoros, C. S. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1066 · Cited by 300
Research works printed but not linked: 31
- Swerdloff, 1976, Endocrinology, 98, 1359, 10.1210/endo-98-6-1359 · DOI · Paper page
- Dubuc, 1977, Horm Metab Res, 9, 95, 10.1055/s-0028-1095550 · DOI
- 10.1038/266060a0 · DOI · Paper page
- Ohtake, 1977, Am J Physiol, 233, 110
- Bray, 1971, Physiol Rev, 51, 598, 10.1152/physrev.1971.51.3.598 · DOI · Paper page
- 10.1038/29795 · DOI · Paper page
- 10.1126/science.7624777 · DOI · Paper page
- 10.1126/science.7624776 · DOI · Paper page
- 10.1038/ng0396-318 · DOI · Paper page
- 10.1210/en.137.7.3144 · doi:10.1210/en.137.7.3144 · Paper page
- 10.1038/43185 · DOI · Paper page
- 10.1079/BJN19970021 · DOI
- Murgatroyd, 1993, Int J Obes Relat Metab Disord, 17, 549
- Fomon, 1982, Am J Clin Nutr, 35, 1169, 10.1093/ajcn/35.5.1169 · DOI · Paper page
- Hamill, 1979, Am J Clin Nutr, 32, 607, 10.1093/ajcn/32.3.607 · DOI · Paper page
- Matarese, 2001, J Immunol, 166, 5909, 10.4049/jimmunol.166.10.5909 · DOI · Paper page
- 10.1001/jama.282.16.1568 · DOI · Paper page
- 10.2337/diabetes.47.4.538 · DOI
- Franssila-Kallunki, 1992, Am J Clin Nutr, 56(Suppl.), 247S, 10.1093/ajcn/56.1.247S · DOI
- 10.1210/jc.85.4.1550 · DOI
- Weinsier, 2000, Am J Clin Nutr, 71, 1138, 10.1093/ajcn/71.5.1138 · DOI · Paper page
- 10.1210/en.140.8.3688 · DOI
- Havel, 2000, Proc Nutr Soc, 59, 69, 10.1017/S0029665100000410 · DOI · Paper page
- 10.1074/jbc.M003549200 · DOI · Paper page
- Dubuc, 1989, Horm Metab Res, 21, 546, 10.1055/s-2007-1009284 · DOI
- 10.1210/jc.84.10.3686 · doi:10.1210/jc.84.10.3686 · Paper page
- 10.1210/en.138.2.855 · doi:10.1210/en.138.2.855 · Paper page
- 10.1038/382250a0 · DOI · Paper page
- 10.1016/S1471-4906(02)02188-9 · DOI · Paper page
- 10.1172/JCI6762 · DOI · Paper page
- 10.1006/cimm.1999.1594 · DOI · Paper page
Cited by
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Obesity in children and young people: a crisis in public health
Lobstein, T., Baur, L., & Uauy, R. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00133.x · Cited by 3,801
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170
Metadata
- Authors
- Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., Lechler, R. I., DePaoli, A. M., & O’Rahilly, S.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-10-15
- Volume
- 110
- Issue
- 8
- Pages
- 1093-1103
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2098025594
- Cited by
- 1,320
- References
- 11
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. https://app.cochat.ai/papers/10.1172/jci15693
- The paper
- Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., Lechler, R. I., DePaoli, A. M., & O’Rahilly, S. (2002). Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Journal of Clinical Investigation. https://doi.org/10.1172/jci15693
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
