The DOI matches its OpenAlex record; 55 of the 55 references it cites were found in a registry or an index.
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
Open accessAbstract
Membrane lipids of the sphingolipid class contain a long-chain sphingoid base backbone (such as sphingosine), an amide-linked, long-chain fatty acid, and one of various polar head groups. The structure of these head groups defines the various sphingolipid subtypes, with a hydroxyl group found in ceramide, phosphorylcholine in sphingomyelin (SM), and carbohydrates in glycosphingolipids (Figure (Figure11 and not shown). Because SM is concentrated in the outer leaflet of the plasma membrane and provides a barrier to the extracellular environment (1), it was long assumed to serve only structural roles. However, in 1987 our laboratory reported for the first time rapid sphingomyelinase (SMase) activation in response to 1,2-diacylglycerols but not phorbol esters (2), and proposed the existence of an SM-based signaling pathway (3, 4). Subsequently, Hannun and coworkers showed that this pathway can be activated by receptor-mediated mechanisms (5) and provided evidence that ceramide is a second messenger (6). Indeed, sphingolipid metabolism has proved to be a dynamic process, and sphingolipid metabolites — including ceramide, sphingosine, and sphingosine 1-phosphate (S1P) — are now recognized as messengers playing essential roles in cell growth, survival, and death (7, 8). Figure 1 Schematic representation of sphingolipid intermediary metabolism.
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Cites
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
Mandala, S., Hajdu, R., Bergstrom, J., Quackenbush, E., Xie, J., Milligan, J., Thornton, R., Shei, G.-J., Card, D., Keohane, C., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,690
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
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Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice
Paris, F., Fuks, Z., Kang, A., Capodieci, P., Juan, G., Ehleiter, D., Haimovitz-Friedman, A., Cordon-Cardo, C., & Kolesnick, R. (2001) · Science · doi:10.1126/science.1060191 · Cited by 1,283
Self-citationSimons, K., & Ikonen, E. (2000) · Science · doi:10.1126/science.290.5497.1721 · Cited by 1,275
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
Olivera, A., & Spiegel, S. (1993) · Nature · doi:10.1038/365557a0 · Cited by 889
Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., & Kolesnick, R. (1995) · Cell · doi:10.1016/0092-8674(95)90429-8 · Cited by 826
Self-citationSignal transduction of stress via ceramide
MATHIAS, S., PEÑA, L. A., & KOLESNICK, R. N. (1998) · Biochemical Journal · doi:10.1042/bj3350465 · Cited by 682
Self-citationLiu, H., Sugiura, M., Nava, V. E., Edsall, L. C., Kono, K., Poulton, S., Milstien, S., Kohama, T., & Spiegel, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002759200 · Cited by 667
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
Siegel, R. M., Frederiksen, J. K., Zacharias, D. A., Chan, F. K.-M., Johnson, M., Lynch, D., Tsien, R. Y., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2354 · Cited by 662
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
Okazaki, T., Bell, R. M., & Hannun, Y. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47268-2 · Cited by 621
Cited by
Sphingosine-1-phosphate: an enigmatic signalling lipid
Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,075
Ceramide-orchestrated signalling in cancer cells
Morad, S. A. F., & Cabot, M. C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3398 · Cited by 1,014
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16390 · Cited by 989
Levy, M., & Futerman, A. H. (2010) · IUBMB Life · doi:10.1002/iub.319 · Cited by 632
“SLs is ceramide, which has received wide attention over the past couple of decades because of its proposed role as an important intracellular signaling molecule involved in regulating differentiation, proliferation, and apoptosis (1, 2).”
BackgroundNutritional and technological aspects of milk fat globule membrane material
Dewettinck, K., Rombaut, R., Thienpont, N., Le, T. T., Messens, K., & Van Camp, J. (2008) · International Dairy Journal · doi:10.1016/j.idairyj.2007.10.014 · Cited by 585
Metadata
- Authors
- Kolesnick, R.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2002-07-01
- Volume
- 110
- Issue
- 1
- Pages
- 3-8
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2093847817
- Cited by
- 393
- References
- 55
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
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