Cholesterol, lipid rafts, and disease

Kai Simons; Robert Ehehalt

doi:10.1172/jci16390

Cited by 989

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Cholesterol, lipid rafts, and disease

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Kai Simons, Robert Ehehalt·2002·Journal of Clinical Investigation

DOI 10.1172/jci16390

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Abstract

Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in eukaryotic cells. In this Perspective, we briefly summarize the structure and regulation of lipid rafts before turning to their evident medical importance. Here, we will give some examples of how rafts contribute to our understanding of the pathogenesis of different diseases. For more information on rafts, the interested reader is referred to recent reviews (1, 2).

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Authors: Simons, K., & Ehehalt, R.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2002-09-01
Volume: 110
Issue: 5
Pages: 597-603
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci16390
OpenAlex: W2061306848
Cited by: 989
References: 2
FWCI: 17.28
Type: journal article
Language: en
Open access: green

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Cholesterol, lipid rafts, and disease

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