Role and Regulation of Wnt/β-Catenin in Hepatic Perivenous Zonation and Physiological Homeostasis

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Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

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Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

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β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

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Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

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New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

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Functional Hepatocellular Heterogeneity

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Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

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Conditional Deletion of β-Catenin Reveals Its Role in Liver Growth and Regeneration

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The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

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Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice†‡

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A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

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New molecular insights into the mechanisms of cholestasis.

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Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

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Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

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Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

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Differential gene expression in periportal and perivenous mouse hepatocytes

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Zonation of hepatic cytochrome P-450 expression and regulation

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Dishevelled and Wnt signaling: is the nucleus the final frontier?

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Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model

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β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

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The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

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T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

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Bile acid synthesis from cholesterol: regulatory and auxiliary pathways

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Role of regucalcin in maintaining cell homeostasis and function (Review)

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Wnt Signaling Regulates Hepatic Metabolism

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Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism

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Cholestasis is a marker for hepatocellular carcinomas displaying β‐<i>catenin</i> mutations

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Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

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Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor

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Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

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OATP1B3 expression is strongly associated with Wnt/β-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma

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Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

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Unbound Bilirubin and Kernicterus in Low-Birth-Weight Infants

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Convergence of Wnt Signaling on the HNF4α-Driven Transcription in Controlling Liver Zonation

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HO-1 overexpression and underexpression: Clinical implications

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WNT10B mutations in human obesity

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Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation

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Liver-Specific β-Catenin Knockout Mice Exhibit Defective Bile Acid and Cholesterol Homeostasis and Increased Susceptibility to Diet-Induced Steatohepatitis

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Regulation of the blood?biliary barrier: interaction between gap and tight junctions in hepatocytes

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The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue

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Untitled work

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Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid–enhanced MR Imaging

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Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

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Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

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Functional compensation precedes recovery of tissue mass following acute liver injury

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A -catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors

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β-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice

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Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

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Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

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Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator–Activated Receptor Alpha (PPARα)

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Transcription dynamics in a physiological process: β-catenin signaling directs liver metabolic zonation.

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Proteomic analysis of β‐catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway

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Glucagon contributes to liver zonation

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Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1

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Liver-Specific β-Catenin Knockout Mice Have Bile Canalicular Abnormalities, Bile Secretory Defect, and Intrahepatic Cholestasis

Yeh, T.-H., Krauland, L., Singh, V., Zou, B., Devaraj, P., Stolz, D. B., Franks, J., Monga, S. P. S., Sasatomi, E., & Behari, J. (2010) · Hepatology · doi:10.1002/hep.23801 · Cited by 81 · see citing works

Hepatic HNF4α deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes

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The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis

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Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

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Cell Polarity Development and Protein Trafficking in Hepatocytes Lacking E-Cadherin/β-Catenin–based Adherens Junctions

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Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus.

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B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

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Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling

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Wnt/β-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver

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β‐Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis

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β-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice

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Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8

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β-Catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice

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Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver

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A Spatial Atlas of Wnt Receptors in Adult Mouse Liver

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Ammonium Hydroxide Enhancement of Dietary Protein in High-Fat Diets Modulates Liver Metabolism Signaling in a Sex- and Age-Dependent Manner in C3H/HeJ Mice

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Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint

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Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint

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Heart-of-Glass: A Regulator at the Heart of Liver Morphogenesis and Metabolic Zonation

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A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liverPreprint

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Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint

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Helping the liver regenerate itself could give patients with end-stage liver disease a treatment option besides waiting for a transplant

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Aider le foie à se régénérer : une piste prometteuse pour des patients condamnés

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Recapitulating Liver Embryology—Lessons to Be Learned for Liver Diseases

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Insulin Growth Factor Binding Protein-6 and the Liver

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Endothelial and Hepatic Stellate Cells Conditioned Media Promote Hepatocyte-like Cell Differentiation and Functional Maturation of mESCs Cultured on 3D Scaffold

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Single-cell and spatial omics in liver identify cell-cell communication regulators in aging and insulin resistance

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Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis

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MASLD: Spatial Mechanisms and New Therapeutics

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