CoChat
Sign Up
Cited by 129Lipid metabolism and biosynthesisAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Energy expenditure, sex, and endogenous fuel availability in humans

Open access
Nielsen, Søren, Guo, ZengKui, Albu, Jeanine B., Klein, Samuel, O’Brien, Peter C., Jensen, Michael D.·2003·Journal of Clinical Investigation
DOI 10.1172/jci16253PMC PMC152581
Open this paper in CoChat — free accountOpen PDF

Abstract

Adipose tissue lipolysis supplies circulating FFAs, which largely meet lipid fuel needs; however, excess FFAs, can contribute to the adverse health consequences of obesity. Because "normal" FFA release has not been well defined, average (mean of 4 days) basal FFA release and its potential regulation factors were measured in 50 lean and obese adults (25 women). Resting energy expenditure (REE), but not body composition, predicted most of the interindividual variation in FFA release. There was a significant, positive linear relationship between palmitate release and REE; however, women released approximately 40% more FFA than men relative to REE. Neither plasma palmitate concentrations nor respiratory quotient by indirect calorimetry differed between men and women. Glucose release rates were not different in men and women whether related to REE or fat free mass. These findings indicate that nonoxidative FFA clearance is greater in women than in men. This could be an advantage at times of increased fuel needs. We conclude that "normal" adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci16253

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 43 references

Research works printed but not linked: 2

  1. Hagenfeldt, 1975, Fed. Proc., 34, 2246
  2. 10.1210/jc.86.12.5813 · DOI

Cited by

Sorted by citations

Items 101–129 of 129

Related

See all

Metadata

Authors
Nielsen, S., Guo, Z., Albu, J. B., Klein, S., O’Brien, P. C., & Jensen, M. D.
Affiliations
  • Mayo Clinic (US)
  • Columbia University (US)
  • Washington University in St. Louis (US)
Corresponding author
Jensen, Michael D.
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2003-04-01
Volume
111
Issue
7
Pages
981-988
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci16253
PMC
PMC152581
OpenAlex
W2058262736
Cited by
129
References
43
Citations by year
2025: 4 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 7
FWCI
3.82
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Mayo Foundation for Medical Education and Research
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • U.S. Public Health Service (DK-40484, DK-50456)
  • Medical Research Council
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 40484, P30DK050456, DK50456, DK37948, R37DK040484, R01DK037948, R01DK040484)
  • National Center for Research Resources (RR 0585, M01RR000585)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
resting energy expenditure, adipose tissue lipolysis, free fatty acid release, sex differences, obesity, palmitate, glucose release, respiratory quotient, fat-free mass
MeSH terms
Adipose Tissue, Adult, Basal Metabolism, Body Composition, Calorimetry, Fatty Acids, Nonesterified, Female, Glucose, Humans, Male, Middle Aged, Obesity, Sex Factors, Time Factors, Multivariate Analysis, Palmitic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review