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Cited by 488

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

Open access
Zimmermann, Nives, King, Nina E., Laporte, Johanne, Yang, Ming, Mishra, Anil, Pope, Sam M., Muntel, Emily E., Witte, David P., Pegg, Anthony A., Foster, Paul S., Hamid, Qutayba, Rothenberg, Marc E.·2003·Journal of Clinical Investigation
DOI 10.1172/jci17912
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Abstract

Asthma is on the rise despite intense, ongoing research underscoring the need for new scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an approach involving expression profiling of lung tissue from mice with experimental asthma. Employing asthma models induced by different allergens and protocols, we identified 6.5% of the tested genome whose expression was altered in an asthmatic lung. Notably, two phenotypically similar models of experimental asthma were shown to have distinct transcript profiles. Genes related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes. In situ hybridization demonstrated marked staining of arginase I, predominantly in submucosal inflammatory lesions. Arginase activity was increased in allergen-challenged lungs, as demonstrated by increased enzyme activity, and increased levels of putrescine, a downstream product. Lung arginase activity and mRNA expression were strongly induced by IL-4 and IL-13, and were differentially dependent on signal transducer and activator of transcription 6. Analysis of patients with asthma supported the importance of this pathway in human disease. Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders.

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Metadata

Authors
Zimmermann, N., King, N. E., Laporte, J., Yang, M., Mishra, A., Pope, S. M., Muntel, E. E., Witte, D. P., Pegg, A. A., Foster, P. S., Hamid, Q., & Rothenberg, M. E.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2003-06-15
Volume
111
Issue
12
Pages
1863-1874
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci17912
OpenAlex
W2129431737
Cited by
488
References
50
FWCI
25.33
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. https://app.cochat.ai/papers/10.1172/jci17912
The paper
Zimmermann, N., King, N. E., Laporte, J., Yang, M., Mishra, A., Pope, S. M., Muntel, E. E., Witte, D. P., Pegg, A. A., Foster, P. S., Hamid, Q., & Rothenberg, M. E. (2003). Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. Journal of Clinical Investigation. https://doi.org/10.1172/jci17912

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.