The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension
Open accessAbstract
Hypertension is a clinical syndrome characterized by increased vascular tone. However, the molecular mechanisms underlying vascular dysfunction during acquired hypertension remain unresolved. Localized intracellular Ca2+ release events through ryanodine receptors (Ca2+ sparks) in the sarcoplasmic reticulum are tightly coupled to the activation of large-conductance, Ca2+-activated K+ (BK) channels to provide a hyperpolarizing influence that opposes vasoconstriction. In this study we tested the hypothesis that a reduction in Ca2+ spark-BK channel coupling underlies vascular smooth muscle dysfunction during acquired hypertension. We found that in hypertension, expression of the beta1 subunit was decreased relative to the pore-forming alpha subunit of the BK channel. Consequently, the BK channels were functionally uncoupled from Ca2+ sparks. Consistent with this, the contribution of BK channels to vascular tone was reduced during hypertension. We conclude that downregulation of the beta1 subunit of the BK channel contributes to vascular dysfunction in hypertension. These results support the novel concept that changes in BK channel subunit composition regulate arterial smooth muscle function.
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Self-citationVasoregulation by the β1 subunit of the calcium-activated potassium channel
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Cited by
Coronary Microvascular Dysfunction
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Metadata
- Authors
- Amberg, G. C., Bonev, A. D., Rossow, C. F., Nelson, M. T., & Santana, L. F.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-09-01
- Volume
- 112
- Issue
- 5
- Pages
- 717-724
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2003272398
- Cited by
- 259
- References
- 34
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Amberg, G. C., Bonev, A. D., Rossow, C. F., Nelson, M. T., & Santana, L. F. (2003). Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension. Journal of Clinical Investigation. https://doi.org/10.1172/jci18684
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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