Cited by 1,298Liver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic DiseasesAlcohol Consumption and Health Effects

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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

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Xu, Aimin, Wang, Yu, Keshaw, Hussila, Xu, Lance Yi, Lam, Karen S.L., Cooper, Garth J.S.·2003·Journal of Clinical Investigation

DOI 10.1172/jci200317797PMC PMC162288

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Abstract

Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained weight loss without affecting food intake. Here we report its potential roles in alcoholic and nonalcoholic fatty liver diseases in mice. Circulating concentrations of adiponectin decreased significantly following chronic consumption of high-fat ethanol-containing food. Delivery of recombinant adiponectin into these mice dramatically alleviated hepatomegaly and steatosis (fatty liver) and also significantly attenuated inflammation and the elevated levels of serum alanine aminotransferase. These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Furthermore, adiponectin treatment could suppress the hepatic production of TNF-α and plasma concentrations of this proinflammatory cytokine. Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases.

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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007

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10.1073/pnas.041591798 · DOI
Kubota, 2002, J. Biol. Chem., 277, 35863
Wilkes, 1996, Am. J. Physiol., 271, E477
Winder, 1999, Am. J. Physiol., 277, E1
10.1210/jc.84.5.1513 · DOI
Funabiki, 2002, Diabetes., 51(Suppl. 2), 32a

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Faheem, S. A., Saeed, N. M., El‐Naga, R. N., Ayoub, I. M., & Azab, S. S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00218 · Cited by 62
Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring
Hyatt, M. A., Gardner, D. S., Sebert, S. P., Wilson, V., Davidson, N. J., Nigmatullina, Y., Chan, L. L. Y., Budge, H., & Symonds, M. E. (2010) · Reproduction · doi:10.1530/rep-10-0325 · Cited by 61
Targeted Overexpression of Inducible 6-Phosphofructo-2-kinase in Adipose Tissue Increases Fat Deposition but Protects against Diet-induced Insulin Resistance and Inflammatory Responses
Huo, Y., Guo, X., Li, H., Xu, H., Halim, V., Zhang, W., Wang, H., Fan, Y.-Y., Ong, K. T., Woo, S., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.370379 · Cited by 63
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling
Wang, L., Luo, Y., Luo, L., Wu, D., Ding, X., Zheng, H., Wu, H., Liu, B., Yang, X., Silva, F. D., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191054 · Cited by 58
Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease
Gatselis, N., Ntaios, G., Makaritsis, K. P., & Dalekos, G. Ν. (2013) · Clinical and Experimental Medicine · doi:10.1007/s10238-012-0227-0 · Cited by 62
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
Tsuchiya, M., Ji, C., Kosyk, O., Shymonyak, S., Melnyk, S., Kono, H., Tryndyak, V., Muskhelishvili, L., Pogribny, I. P., Kaplowitz, N., et al. (2012) · Hepatology · doi:10.1002/hep.25641 · Cited by 60
Current Experimental Perspectives on the Clinical Progression of Alcoholic Liver Disease
Breitkopf, K., Nagy, L. E., Beier, J. I., Mueller, S., Weng, H., & Dooley, S. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01015.x · Cited by 60
Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice
Shen, H., Jiang, L., Lin, J. D., Omary, M. B., & Rui, L. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124376 · Cited by 62
High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes
Neumeier, M., Sigrüener, A., Eggenhofer, E., Weigert, J., Weiß, T. S., Schaeffler, A., Schlitt, H. J., Aslanidis, C., Piso, P., Langmann, T., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.058 · Cited by 59
Pharmacological agents for NASH
Ratziu, V. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.193 · Cited by 59
Adipokines and Redox Signaling: Impact on Fatty Liver Disease
Parola, M., & Marra, F. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3848 · Cited by 60
Preatherosclerosis and Adiponectin Subfractions in Obese Adolescents
Mangge, H., Almer, G., Haj‐Yahya, S., Pilz, S., Gasser, R. N. A., Möller, R., & Horejsi, R. (2008) · Obesity · doi:10.1038/oby.2008.439 · Cited by 59
Vitamin D in liver disease: Current evidence and potential directions
Elangovan, H., Chahal, S., & Gunton, J. E. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.001 · Cited by 59
Visceral Adiposity Predicts Severity of Acute Pancreatitis
Natu, A., Stevens, T., Kang, L., Yasinow, S., Mansoor, E., López, R., Glessing, B. R., Remer, E. M., Richards, T. J., Gupta, A. B., et al. (2017) · Pancreas · doi:10.1097/mpa.0000000000000845 · Cited by 56
A novel role for adiponectin in regulating the immune responses in chronic hepatitis C virus infection†‡
Palmer, C. S., Hampartzoumian, T., Lloyd, A. R., & Zekry, A. (2008) · Hepatology · doi:10.1002/hep.22387 · Cited by 59
Nonalcoholic Fatty Liver Disease: Clinical Features and Pathogenesis.
Başaranoğlu, M., & Neuschwander‐Tetri, B. A. (2006) · PubMed Central · Cited by 58
Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis
Zeng, T., & Xie, K. (2009) · Archives of Toxicology · doi:10.1007/s00204-009-0457-4 · Cited by 58
Mapping body fat distribution: A key step towards the identification of the vulnerable patient?
Arsenault, B. J., Pelletier-Beaumont, É., Després, J., & Larose, É. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.605387 · Cited by 57
The multifaceted and controversial immunometabolic actions of adiponectin
Esmaili, S., Xu, A., & George, J. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.06.001 · Cited by 57
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Serum Adiponectin Is Reduced in Acromegaly and Normalized after Correction of Growth Hormone Excess
Lam, K. S. L., Xu, A., Tan, K. C. B., Wong, L. S. L., Tiu, S.-C., & Tam, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032023 · Cited by 58
Self-citation
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity
Baeza-Raja, B., Sachs, B. D., Li, P., Frank, C., Vagena, E., Davalos, D., Moan, N. L., Ryu, J. K., Sikorski, S. L., Chan, J. P., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.12.028 · Cited by 62
MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease
Μacut, D., Antić, I. B., Bjekić-Macut, J., & Τζιόμαλος, Κ. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-1063 · Cited by 58
Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B
Hui, C., Zhang, H., Lee, N. P. Y., Chan, W., Yueng, Y., Leung, K.-W., Lu, L., Leung, N. W. Y., Lo, C., Fan, S.-T., et al. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.02.023 · Cited by 56
Self-citation
Vascular Actions of Adipokines
Xu, A., Wang, Y., Lam, K. S. L., & Vanhoutte, P. M. (2010) · Advances in pharmacology · doi:10.1016/b978-0-12-385061-4.00008-8 · Cited by 58
Self-citation
Metastasis suppression by adiponectin
Saxena, N. K., & Sharma, D. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.3.11541 · Cited by 57
Adiponectin and lipid metabolism in skeletal muscle
Lee, B., & Shao, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.008 · Cited by 62
Alleviation of High-Fat Diet-Induced Fatty Liver Damage in Group IVA Phospholipase A2-Knockout Mice
Ii, H., Yokoyama, N., Yoshida, S., Tsutsumi, K., Hatakeyama, S., Sato, T., Ishihara, K., & Akiba, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008089 · Cited by 57

Authors: Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L., & Cooper, G. J. S.
Affiliations: University of Auckland (NZ)
University of Hong Kong (HK)
Corresponding author: Xu, Aimin
ORCID: Xu, Aimin
Wang, Yu
Lam, Karen S.L.
Cooper, Garth J.S.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2003-07-01
Volume: 112
Issue: 1
Pages: 91-100
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200317797
PMC: PMC162288
OpenAlex: W2120590109
Cited by: 1,298
References: 68
Citations by year: 2026: 12 · 2025: 15 · 2024: 29 · 2023: 34 · 2022: 34 · 2021: 43 · 2020: 38 · 2019: 35 · 2018: 54 · 2017: 50 · 2016: 50 · 2015: 69 · 2014: 75 · 2013: 59 · 2012: 68
FWCI: 49.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: Auckland Medical Research Foundation
University of Hong Kong
Health Research Council of New Zealand
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: adiponectin, alcoholic fatty liver, non-alcoholic fatty liver disease, hepatic steatosis, hepatomegaly, liver inflammation, TNF-α, carnitine palmitoyltransferase 1, hepatic fatty acid oxidation, fatty acid synthesis, acetyl-CoA carboxylase, fatty acid synthase, alanine aminotransferase, ob/ob mice, obesity
MeSH terms: Alanine Transaminase, Animals, Fatty Acids, Fatty Liver, Fatty Liver, Alcoholic, Liver, Male, Mice, Inbred C57BL, Obesity, Morbid, Oxidation-Reduction, Proteins, Recombinant Proteins, Tumor Necrosis Factor-alpha, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin

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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

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