The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Bmi1, stem cells, and senescence regulation
Open accessAbstract
Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms.Therefore, senescence of stem cells must be prevented.Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.
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“However, many adult stem or progenitor cells do not proliferate indefinitely, whether mouse or human in origin (Geiger and Van Zant, 2002; Chen, 2004; Park et al., 2004; Villa et al., 2004).”
From Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors (2005) · cites this paper as Park et al., 2004
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“Several studies suggest a role for polycomb group proteins in the regulation of expression from the Ink4a/Arf locus, and Bmi1, a key component of the polycomb complex, has been widely implicated in this process (37,38).”
From Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice (2009) · cites this paper as [37]
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Citations
Cites
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A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
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Cited by
Sorted by citations
Identification of Pancreatic Cancer Stem Cells
Li, C., Heidt, D. G., Dalerba, P. D., Burant, C., Zhang, L., Adsay, V. N., Wicha, M. S., Clarke, M. F., & Simeone, D. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2030 · Cited by 3,419
Self-citationSenescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Prince, M. E., Sivanandan, R., Kaczorowski, A., Wolf, G. T., Kaplan, M. J., Dalerba, P. D., Weissman, I. L., Clarke, M. F., & Ailles, L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610117104 · Cited by 2,204
Self-citationInk4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L. K., Klein, O. D., & de Sauvage, F. J. (2011) · Nature · doi:10.1038/nature10408 · Cited by 1,244
Metadata
- Authors
- Park, I.-K., Morrison, S. J., & Clarke, M. F.
- Affiliations
- University of Michigan (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2004-01-15
- Volume
- 113
- Issue
- 2
- Pages
- 175-179
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC311443
- OpenAlex
- W2104666653
- Cited by
- 495
- References
- 59
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 7 · 2023: 13 · 2022: 19 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 19 · 2017: 24 · 2016: 37 · 2015: 33 · 2014: 20 · 2013: 37 · 2012: 30
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- BMI1, stem cells, cellular senescence, stem cell maintenance, longevity, cell death, gene repression
- MeSH terms
- Animals, Cell Line, Gene Expression Regulation, Humans, Models, Biological, Mutation, Nuclear Proteins, Proto-Oncogene Proteins, Repressor Proteins, Stem Cells, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Tumor Suppressor Protein p14ARF, Mice, Polycomb Repressive Complex 1
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