Cited by 495Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

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Bmi1, stem cells, and senescence regulation

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Park, In-Kyung, Morrison, Sean J., Clarke, Michael F.·2004·Journal of Clinical Investigation

DOI 10.1172/jci200420800PMC PMC311443

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Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms.Therefore, senescence of stem cells must be prevented.Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

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Self-citation
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,848
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,889
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Self-citation
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485

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Research works printed but not linked: 5

Pathak, 2002, Anticancer Res., 22, 1353
Haupt, 1993, Oncogene., 8, 316
Bea, 2001, Cancer Res., 61, 2409
Quelle, 1995, Cell., 84, 993
Dimri, 2002, Cancer Res., 62, 4736

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Histone modifications silence the GATA transcription factor genes in ovarian cancer
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Authors: Park, I.-K., Morrison, S. J., & Clarke, M. F.
Affiliations: University of Michigan (US)
ORCID: Park, In-Kyung
Morrison, Sean J.
Clarke, Michael F.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-01-15
Volume: 113
Issue: 2
Pages: 175-179
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200420800
PMC: PMC311443
OpenAlex: W2104666653
Cited by: 495
References: 59
Citations by year: 2026: 7 · 2025: 11 · 2024: 7 · 2023: 13 · 2022: 19 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 19 · 2017: 24 · 2016: 37 · 2015: 33 · 2014: 20 · 2013: 37 · 2012: 30
FWCI: 15.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: BMI1, stem cells, cellular senescence, stem cell maintenance, longevity, cell death, gene repression
MeSH terms: Animals, Cell Line, Gene Expression Regulation, Humans, Models, Biological, Mutation, Nuclear Proteins, Proto-Oncogene Proteins, Repressor Proteins, Stem Cells, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Tumor Suppressor Protein p14ARF, Mice, Polycomb Repressive Complex 1

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Bmi1, stem cells, and senescence regulation

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