The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
Open accessAbstract
Epidemiological evidence points to the inverse relationship between microbial exposure and the prevalence of allergic asthma and autoimmune diseases in Westernized countries.The molecular basis for this observation has not yet been completely delineated.Here we report that the administration of certain toll-like receptor (TLR) ligands, via the activation of innate immunity, induces high levels of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism in various organs.TLR9 ligand-induced pulmonary IDO activity inhibits Th2-driven experimental asthma.IDO activity expressed by resident lung cells rather than by pulmonary DCs suppressed lung inflammation and airway hyperreactivity.Our results provide a mechanistic insight into the various formulations of the hygiene hypothesis and underscore the notion that activation of innate immunity can inhibit adaptive Th cell responses.Nonstandard abbreviations used: airway hyperreactivity (AHR); 7-amino actinomycin D (7-AAD); bone marrow-derived DC (BMDC); enhanced pause (Penh); flagellin (Flag); IFN-α/β receptor (IFN-α/βR); IL-1β receptor (IL-1βR); immunostimulatory sequence oligodeoxynucleotide (ISS-ODN); indoleamine 2,3 dioxygenase (IDO); kynurenine (KYN); methacholine (MCh); 1-methyl-DL-tryptophan (M-trp); Pam3Cys-Ser-(Lys)-4-3HCl (P3C); poly I:C (pI:C); regulatory T cell (Treg); transgenic (Tg); tryptophan (trp). Conflict of interest:The authors have declared that no conflict of interest exists.
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Cites
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Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism
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Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
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Modulation of tryptophan catabolism by regulatory T cells
Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M.-L., & Puccetti, P. (2003) · Nature Immunology · doi:10.1038/ni1003 · Cited by 1,374
The Inverse Association Between Tuberculin Responses and Atopic Disorder
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CTLA-4–Ig regulates tryptophan catabolism in vivo
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Cited by
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells
Marigo, I., Dolcetti, L., Serafini, P., Zanovello, P., & Bronte, V. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00602.x · Cited by 608
Hou, D.-Y., Muller, A. J., Sharma, M. D., DuHadaway, J., Banerjee, T., Johnson, M., Mellor, A. L., Prendergast, G. C., & Munn, D. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2925 · Cited by 586
NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns
Massudi, H., Grant, R., Guillemin, G. J., & Braidy, N. (2012) · Redox Report · doi:10.1179/1351000212y.0000000001 · Cited by 158
Forsythe, P. (2011) · Chest · doi:10.1378/chest.10-1861 · Cited by 131
Metadata
- Authors
- Hayashi, T., Beck, L., Rossetto, C., Gong, X., Takikawa, O., Takabayashi, K., Broide, D. H., Carson, D. A., & Raz, E.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-07-15
- Volume
- 114
- Issue
- 2
- Pages
- 270-279
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2057001364
- Cited by
- 344
- References
- 49
- FWCI
- 20.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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