Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

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Mechanisms and therapeutics of insulin signaling transduction genes in diabetic cardiomyopathy: a comprehensive updated review

He, Y., Yang, X., He, X., Wang, G., Li, C., Yuan, P., & Li, C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1589695 · Cited by 14

Insulin therapy improves islet functions by restoring pancreatic vasculature in high‐fat diet‐fed streptozotocin‐diabetic rats (胰岛素治疗通过恢复胰腺血管提高高脂饮食联合链脲佐菌素诱导的糖尿病大鼠的胰岛功能)

Gu, H., Xia, X., Chen, Z., Liang, H., Yan, J., Xu, F. L., & Weng, J. (2013) · Journal of Diabetes · doi:10.1111/1753-0407.12095 · Cited by 9

Distinct roles of systemic and local actions of insulin on pancreatic β-cells

Kitamoto, T., Sakurai, K., Lee, E. Y., Yokote, K., Accili, D., & Miki, T. (2018) · Metabolism · doi:10.1016/j.metabol.2017.12.017 · Cited by 8

A genomewide study of body mass index and its genetic correlation with thromboembolic risk

Pena, G. D. G., Ziyatdinov, A., Buil, A., López, S., Fontcuberta, J., Soria, J. M., & Souto, J. C. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-03-0275 · Cited by 8

Insulin and insulin-receptor signaling in the brain

Бондарева, В. М., & Chistyakova, O. V. (2007) · Neurochemical Journal · doi:10.1134/s1819712407030026 · Cited by 8

A positive effect of intranasal insulin on spatial memory in rats with neonatal diabetes mellitus

Chistyakova, O. V., Бондарева, В. М., Шипилов, В. Н., Sukhov, I. B., & Shpakov, A. O. (2011) · Endocrinology Studies · doi:10.4081/es.2011.e16 · Cited by 8

Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader‐Willi syndrome

Kweh, F. A., Sulsona, C. R., Miller, J. L., & Driscoll, D. J. (2023) · Obesity Science & Practice · doi:10.1002/osp4.663 · Cited by 7

Tissue-Specific Ablation of Tsc1 in Pancreatic Beta-Cells

Mori, H., & Guan, K. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_26 · Cited by 7

Identification of proteins highly expressed in uterine fluid from mice with hydrometra

Antonson, P., Nalvarte, I., Varshney, M., Li, X., Windahl, S. H., Humire, P., Ohlsson, C., Gustafsson, J.-Α., & Dahlman‐Wright, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.099 · Cited by 7

Histone deacetylase 6 regulates insulin signaling in pancreatic β cells

Inoue, H., Asahara, S., Sugiura, Y., Kawada, Y., Imai, A., Hara, C., Kanno, A., Kimura-Koyanagi, M., & Kido, Y. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.078 · Cited by 8

Regulation of mitochondrial metabolism by hibernating bear serum: Insights into seasonal metabolic adaptations

Elfeky, M., Tsubota, A., Shimozuru, M., Tsubota, T., Kimura, K., & Okamatsu‐Ogura, Y. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150510 · Cited by 6

Featured Article: Beta cell specific pyruvate dehydrogenase alpha gene deletion results in a reduced islet number and β-cell mass postnatally

Patel, M. S., Srinivasan, M., Strutt, B. J., Mahmood, S., & Hill, D. J. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214531895 · Cited by 6

Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells

Yoshikawa, N., Nemoto, T., Satoh, S., Maruta, T., Yanagita, T., Chosa, E., & Wada, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.08.013 · Cited by 6

Expression of MCP-1 in white adipose tissues induce the resistin-hypersecretion in type 2 diabetes

Hashimoto, H., Eto, T., Kawai, K., Akimoto, T., & Hioki, K. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100286 · Cited by 5

Hormonal, electrolyte disturbances and features of hemostasis in term newborn infants of mothers with gestational diabetes mellitus.

Mikhalev, E. V., Shanina, O. M., & Саприна, Т. В. (2015) · Diabetes Mellitus · doi:10.14341/dm2015178-86 · Cited by 5

Contribution of insulin signaling to the regulation of pancreatic beta-cell mass during the catch-up growth period in a low birth weight mouse model

Yoshida, Y., Fuchita, M., Kimura-Koyanagi, M., Kanno, A., Matsuda, T., Asahara, S., Hashimoto, N., Isagawa, T., Ogawa, W., Aburatani, H., et al. (2013) · Diabetology International · doi:10.1007/s13340-013-0127-x · Cited by 4

Insulin and Leptin Levels in Appropriate-for-Gestational-Age Infants of Diabetic Mother.

Vela-Huerta, M. M., Amador‐Licona, N., Anaya-Aguirre, S., Mendoza, J. M. G., Velazquez-Bustamante, A., & Murillo-Ortiz, B. O. (2012) · Europe PMC (PubMed Central) · Cited by 4

Transcriptomic and epigenetic alterations in aging-related genes in the medaka liver due to ancestral BPA exposure

Chakraborty, S., Nickel, T. J., Anand, S. K., & Bhandari, R. K. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag028 · Cited by 2

Gut-Derived GLP-1 Released by Rare Sugar d -Allulose Cooperates With Insulin to Activate Left-Sided Vagal Afferents and Enhance Insulin Sensitivity

Ohbayashi, K., Tanida, M., Abe, C., Ishihara, H., Omi, W., Kubota, N., Drucker, D. J., Yada, T., & Iwasaki, Y. (2026) · Diabetes · doi:10.2337/db25-1134 · Cited by 4

Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis

Taniguchi, C. M., & Kahn, C. R. (2011) · Energy balance and cancer · doi:10.1007/978-1-4419-9911-5_2 · Cited by 5

Obese Mouse Models

Good, D. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-285-4_71 · Cited by 3

The potentiality of histone deacetylase inhibitors for diabetes and obesity

El-Serafi, A. T., & Serafi, I. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816422-8.00015-5 · Cited by 3

Obesity: Nature or Nurture?

Lustig, R. H. (2010) · Endocrine updates · doi:10.1007/978-1-4419-7034-3_1 · Cited by 2

Insulin Action in the Islet β-Cell

Kulkarni, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-72204-7_7 · Cited by 2

Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice

Senda, S., Inoue, A., Mahmood, A., Suzuki, R., Kamei, N., Kubota, N., Watanabe, T., Aoyama, M., Nawaz, A., Ohkuma, Y., et al. (2015) · Diabetology International · doi:10.1007/s13340-015-0205-3 · Cited by 2

The role of insulin receptor substrate 2 in hypothalamic and β cell function

Choudhury, A. I., Heffron, H., Smith, M. A., Al‐Qassab, H., Xu, A. W., Selman, C., Simmgen, M., Clements, M., Claret, M., MacColl, G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24445 · Cited by 244

The role of insulin receptor substrate 2 in beta cell function

Heffron, H. (2007) · Doctoral thesis, UCL (University College London).

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Kubota, N., Tobe, K., Terauchi, Y., Eto, K., Yamauchi, T., Suzuki, R., Tsubamoto, Y., Komeda, K., Nakano, R., Miki, H., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1880 · Cited by 519

Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes

Lin, X., Taguchi, A., Park, S., Kushner, J. A., Li, F., Li, Y., & White, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22217 · Cited by 313

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

Cantley, J., Choudhury, A. I., Asare‐Anane, H., Selman, C., Lingard, S. J., Heffron, H., Herrera, P. L., Persaud, S. J., & Withers, D. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0637-9 · Cited by 79