Cited by 623Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsMitochondrial Function and Pathology

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Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

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Wilson-Fritch, Leanne, Nicoloro, Sarah, Chouinard, My, Lazar, Mitchell A., Chui, Patricia C., Leszyk, John, Straubhaar, Juerg, Czech, Michael P., Corvera, Silvia·2004·Journal of Clinical Investigation

DOI 10.1172/jci21752PMC PMC524228

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Abstract

Adipose tissue plays a central role in the control of energy homeostasis through the storage and turnover of triglycerides and through the secretion of factors that affect satiety and fuel utilization. Agents that enhance insulin sensitivity, such as rosiglitazone, appear to exert their therapeutic effect through adipose tissue, but the precise mechanisms of their actions are unclear. Rosiglitazone changes the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes. To examine the relevance of these effects in vivo, we studied white adipocytes from ob/ob mice during the development of obesity and after treatment with rosiglitazone. The levels of approximately 50% of gene transcripts encoding mitochondrial proteins were decreased with the onset of obesity. About half of those genes were upregulated after treatment with rosiglitazone, and this was accompanied by an increase in mitochondrial mass and changes in mitochondrial structure. Functionally, adipocytes from rosiglitazone-treated mice displayed markedly enhanced oxygen consumption and significantly increased palmitate oxidation. These data reveal mitochondrial remodeling and increased energy expenditure in white fat in response to rosiglitazone treatment in vivo and suggest that enhanced lipid utilization in this tissue may affect whole-body energy homeostasis and insulin sensitivity.

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Authors: Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S.
Affiliations: University of Massachusetts Chan Medical School (US)
University of Pennsylvania (US)
Corresponding author: Corvera, Silvia
ORCID: Nicoloro, Sarah
Lazar, Mitchell A.
Straubhaar, Juerg
Czech, Michael P.
Corvera, Silvia
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-11-01
Volume: 114
Issue: 9
Pages: 1281-1289
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci21752
PMC: PMC524228
OpenAlex: W2022473709
Cited by: 616
References: 32
Citations by year: 2026: 4 · 2025: 13 · 2024: 21 · 2023: 19 · 2022: 23 · 2021: 17 · 2020: 34 · 2019: 22 · 2018: 28 · 2017: 32 · 2016: 32 · 2015: 36 · 2014: 42 · 2013: 44 · 2012: 33
FWCI: 15.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK60837-02)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondrial remodeling, adipose tissue, obesity, rosiglitazone, white adipocytes, ob/ob mice, insulin sensitivity, energy homeostasis, mitochondrial mass, mitochondrial structure, oxygen consumption, palmitate oxidation, lipid utilization, 3T3-L1 adipocytes, mitochondrial gene expression
MeSH terms: Rosiglitazone, Adipose Tissue, Animals, Blood Glucose, Fatty Acids, Insulin, Mice, Inbred C57BL, Mice, Obese, Mice, Transgenic, Microscopy, Fluorescence, Mitochondria, Obesity, Oxygen, RNA, Messenger, Mass Spectrometry, Time Factors, Vasodilator Agents, Blotting, Northern, Blotting, Western, Adipocytes, RNA, Complementary, Chaperonin 60, Palmitic Acid, Oligonucleotide Array Sequence Analysis, 3T3-L1 Cells, Thiazolidinediones, PPAR gamma, Mice

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Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

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