The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Open accessAbstract
Adipose tissue plays a central role in the control of energy homeostasis through the storage and turnover of triglycerides and through the secretion of factors that affect satiety and fuel utilization. Agents that enhance insulin sensitivity, such as rosiglitazone, appear to exert their therapeutic effect through adipose tissue, but the precise mechanisms of their actions are unclear. Rosiglitazone changes the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes. To examine the relevance of these effects in vivo, we studied white adipocytes from ob/ob mice during the development of obesity and after treatment with rosiglitazone. The levels of approximately 50% of gene transcripts encoding mitochondrial proteins were decreased with the onset of obesity. About half of those genes were upregulated after treatment with rosiglitazone, and this was accompanied by an increase in mitochondrial mass and changes in mitochondrial structure. Functionally, adipocytes from rosiglitazone-treated mice displayed markedly enhanced oxygen consumption and significantly increased palmitate oxidation. These data reveal mitochondrial remodeling and increased energy expenditure in white fat in response to rosiglitazone treatment in vivo and suggest that enhanced lipid utilization in this tissue may affect whole-body energy homeostasis and insulin sensitivity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“White adipocyte mitochondrial content is decreased in both rodent and human obesity (177, 188 -191) and correlates with insulin resistance that accompanies obesity.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [177]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Administration of thiazolidinediones induces changes in mitochondrial content and remodeling in white adipocytes concomitantly with an improvement in insulin sensitivity (170, 173, 177, 190, 194 -198).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [177]
In the citing paper
“Higher mitochondrial density and even UCP1 can be induced in response to pharmacological or genetic alterations of white adipocytes (170 -177), suggesting that white adipose tissue could potentially be induced to acquire more oxidative metabolic phenotypes, promoting increased fuel consumption and thus energy expenditure.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [177]
In the citing paper
“Conversely, both genetic and dietinduced obesity result in decreased mitochondrial density and OXPHOS activity in adipose tissue (127, 177, 189 -191), potentially contributing to adipose tissue dysfunction and exacerbation of insulin resistance.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [177]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,204
Okuno, A., Tamemoto, H., Kazuuki, T. O. B. E., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1235 · Cited by 995
Miyazaki, Y., Mahankali, A., Matsuda, M., Mahankali, S., Hardies, J., Cusi, K., Mandarino, L. J., & DeFronzo, R. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8567 · Cited by 726
Cited by
Sorted by citations
Items 401–500 of 623
The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes
Bond, S. T., Moody, S. C., Liu, Y., Civelek, M., Villanueva, C. J., Gregorevic, P., Kingwell, B. A., Hevener, A. L., Lusis, A. J., Henstridge, D. C., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00394.2018 · Cited by 23
Schöttl, T., Pachl, F., Giesbertz, P., Daniel, H., Küster, B., Fromme, T., & Klingenspor, M. (2020) · Obesity · doi:10.1002/oby.22737 · Cited by 23
Barberio, M. D., Nadler, E. P., Sevilla, S., Lu, R., Harmon, B. T., & Hubal, M. J. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0494-y · Cited by 23
Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis
Cignarelli, A., Giorgino, F., & Vettor, R. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.796996 · Cited by 22
Monaco, C. M. F., Proudfoot, R., Miotto, P. M., Herbst, E. A. F., MacPherson, R. E. K., & Holloway, G. P. (2017) · Diabetologia · doi:10.1007/s00125-017-4456-3 · Cited by 22
Pin, L., Ji, H., Li, C., Chen, L., & Du, Z. (2015) · 中国科学通报:英文版 · doi:10.1007/s11434-015-0833-9 · Cited by 22
Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin
Keuper, M., Berti, L., Raedle, B., Sachs, S., Böhm, A., Fritsche, L., Fritsche, A., Häring, H., de Angelis, M. H., Jastroch, M., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.11.006 · Cited by 21
Tapía, P., Fernández‐Galilea, M., Robledo, F., Mardones, P., Galgani, J. E., & Cortés, V. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12389 · Cited by 21
Kim, D. H., Sartor, M. A., Bain, J. R., Sandoval, D. A., Stevens, R. D., Medvedovic, M., Newgard, C. B., Woods, S. C., & Seeley, R. J. (2012) · Diabetes · doi:10.2337/db11-1579 · Cited by 21
Maassen, J. A., Hart, L. M. ‘., & Ouwens, D. M. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0b774 · Cited by 21
Pagel, I., Schwartz, D. R., Arena, R. A., Minerbi, D. C., Johnson, D., Waclawiw, M. A., Cannon, R. O., Balaban, R. S., Tripodi, D. J., & Sack, M. N. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00782.2007 · Cited by 21
Pharmacogenomics of Metabolic Effects of Rosiglitazone
Šeda, O., Šedová, L., Oliyarnyk, O., Kazdová, L., K⊘enová, D., Corbeil, G., Hamet, P., Tremblay, J., & K⊘en, V. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.2.141 · Cited by 21
Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens
Torchon, E., Ray, R. B., Hulver, M. W., McMillan, R. P., & Voy, B. H. (2016) · Adipocyte · doi:10.1080/21623945.2016.1263777 · Cited by 20
Development, activation, and therapeutic potential of thermogenic adipocytes
Emont, M. P., Kim, D., & Wu, J. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.05.004 · Cited by 20
Peng, H., Zhang, C., Wang, M., Zhang, W., Xu, B., Yan, X., Xin, H., & Wang, X. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2020.100577 · Cited by 20
Thonpho, A., Rojvirat, P., Jitrapakdee, S., & MacDonald, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055139 · Cited by 20
Villarroya, J., Dorado, B., Vilà, M. R., García‐Arumí, E., Domingo, P., Giralt, M., Hirano, M., & Villarroya, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029691 · Cited by 20
Yang, J., Yang, J., Wang, L., Moore, A. V., Liang, S. H., & Ran, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-09018-2 · Cited by 20
Peanut Shell Extract and Luteolin Regulate Lipid Metabolism and Induce Browning in 3T3-L1 Adipocytes
Liu, W., Wang, L., & Zhang, J. (2022) · Foods · doi:10.3390/foods11172696 · Cited by 19
Valdivia, L. F., Castro, É., Eichler, R. A. D. S., Moreno, M. F., de Sousa, É., Jardim, G. F. R., Peixoto, Á. S., Moraes, M. N., Castrucci, A. M. D. L., Nedergaard, J., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2022 · Cited by 19
Weighing in on the role of brown adipose tissue for treatment of obesity
Prapaharan, B., Lea, M. B. S., & Beaudry, J. L. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.13157 · Cited by 19
Han, Y., Ye, S., & Liu, B. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1409000 · Cited by 19
Nutrigenomic Functions of PPARs in Obesogenic Environments
Chung, S., Kim, Y. J., Yang, S. J., Lee, Y., & Lee, M. (2016) · PPAR Research · doi:10.1155/2016/4794576 · Cited by 19
Time‐dependent effect of phytocannabinoid treatments in fat cells
Ramlugon, S., Levendal, R. ‐., & Frost, C. L. (2018) · Phytotherapy Research · doi:10.1002/ptr.6047 · Cited by 19
Transcriptional control and hormonal response of thermogenic fat
Emont, M. P., Yu, H. M., & Wu, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0026 · Cited by 19
Key factors involved in obesity development
Wang, Z., Yuan, D., Duan, Y., Li, S., & Hou, S. (2017) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-017-0428-3 · Cited by 19
Finlin, B. S., Memetimin, H., Zhu, B., Confides, A. L., Vekaria, H. J., Khouli, R. H. E., Johnson, Z., Westgate, P. M., Chen, J., Morris, A. J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.143650 · Cited by 19
Hruška, P., Kucera, J., Kuruczová, D., Bužga, M., Pekár, M., Holéczy, P., Potěšil, D., Zdráhal, Z., & Vašků, J. B. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2023 · Cited by 18
Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1
Petrosino, J. M., Longenecker, J. Z., Ramkumar, S., Xu, X., Dorn, L. E., Bratasz, A., Yu, L., Maurya, S. K., Tolstikov, V., Bussberg, V., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141799 · Cited by 18
Novel adipocyte features discovered by adipoproteomics
Renes, J., Rosenow, A., & Mariman, E. C. M. (2009) · Adipobiology · doi:10.14748/adipo.v1.245 · Cited by 18
The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone.
Goetzman, E. S. (2009) · Obesity · doi:10.1038/oby.2008.467 · Cited by 17
Festuccia, W. T., Blanchard, P.-G., de Oliveira, T. B., Magdalon, J., Paschoal, V. A., Richard, D., & Deshaies, Y. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00299.2012 · Cited by 17
White adipose tissue mitochondrial bioenergetics in metabolic diseases
Sabaratnam, R., Hansen, D. R., & Svenningsen, P. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09827-z · Cited by 17
Guallar, J. P., Rojas‐García, R., García‐Arumí, E., Domingo, J. C., Gallardo, E., Andreu, A. L., Domingo, P., Illa, I., Giralt, M., & Villarroya, F. (2008) · Journal of Medical Case Reports · doi:10.1186/1752-1947-2-284 · Cited by 17
Hammarstedt, A., Pihlajamäki, J., Graham, T. E., Kainulainen, S., Kahn, B. B., Laakso, M., & Smith, U. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01914.x · Cited by 17
Martens, L. G., Luo, J. M., Wermer, M. J. H., van Dijk, K. W., Hägg, S., Graßmann, F., Noordam, R., & van Heemst, D. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.06.1012 · Cited by 16
AlZaim, I., Eid, A. H., Abd‐Elrahman, K. S., & EL‐Yazbi, A. F. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115337 · Cited by 16
cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis
Desai, A., Loureiro, Z. Y., DeSouza, T., Yang, Q., Solivan-Rivera, J., & Corvera, S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102051 · Cited by 17
Self-citationMirzaei, K., Hossein‐Nezhad, A., Emamgholipour, S., Ansar, H., Khosrofar, M., Tootee, A., & Alatab, S. (2012) · Lifestyle Genomics · doi:10.1159/000337352 · Cited by 16
Yin, Y., Wu, Y., Zhang, X., Zhu, Y., Sun, Y., Yu, J., Gong, Y., Sun, P. G., Lin, H., & Han, X. (2021) · Diabetes · doi:10.2337/db20-0622 · Cited by 16
LMO3 reprograms visceral adipocyte metabolism during obesity
Wagner, G., Fenzl, A., Lindroos‐Christensen, J., Einwallner, E., Husa, J., Witzeneder, N., Rauscher, S., Gröger, M., Derdak, S. V., Mohr, T. T., et al. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02089-9 · Cited by 16
Vincent, A., Louveau, I., Gondret, F., Lebret, B., & Damon, M. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00098.2012 · Cited by 16
Bacterial oxygenases: In vivo enzyme biosensors for organic pollutants
Tizzard, A. C., & Lloyd-Jones, G. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2006.08.027 · Cited by 16
Sharkey, D., Fainberg, H. P., Wilson, V., Harvey, E., Gardner, D. S., Symonds, M. E., & Budge, H. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.122812 · Cited by 16
EID1-induces brown-like adipocyte traits in white 3T3-L1 pre-adipocytes
Lizcano, F., & Vargas, D. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.034 · Cited by 15
Raj, R. R., Lofquist, S., & Lee, M. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03377-w · Cited by 16
Pardo, R., Velilla, M., Herrero, L., Cervela‐Cardona, L., Ribeiro, M. L., Simó, R., & Villena, J. A. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000672 · Cited by 15
Rocha, K. K. H. R., Souza, G. A., Seiva, F. R. F., Ebaid, G. M. X., & Novelli, E. L. B. (2010) · Alcohol and Alcoholism · doi:10.1093/alcalc/agq085 · Cited by 15
Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes
Hartig, S. M., Bader, D. A., Abadie, K., Motamed, M., Hamilton, M. P., Long, W., York, B., Mueller, M., Wagner, M., Trauner, M., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1084 · Cited by 15
Alligier, M., Dewulf, E. M., Salazar, N., Mairal, A., Neyrinck, A. M., Cani, P. D., Langin, D., & Delzenne, N. M. (2014) · Obesity · doi:10.1002/oby.20733 · Cited by 14
Botezelli, J. D., Overby, P., Lindo, L., Wang, S., Haïda, O., Lim, G. E., Templeman, N. M., Pauli, J. R., & Johnson, J. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00128.2020 · Cited by 14
Ye, F., Lemieux, H., Hoppel, C. L., Hanson, R. W., Hakimi, P., Croniger, C. M., Puchowicz, M. A., Anderson, V. E., Fujioka, H., & Stavnezer, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.292029 · Cited by 14
Kodde, A., van der Beek, E. M., Phielix, E., Engels, E., Schipper, L., & Oosting, A. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0191-5 · Cited by 15
Physiological regulation and metabolic role of browning in white adipose tissue
Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14
PDE 5 inhibitor improves insulin sensitivity by enhancing mitochondrial function in adipocytes
Yu, H. M., Chung, H. K., Kim, K. S., Lee, J. M., Hong, J. H., & Park, K. S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.140 · Cited by 14
Wessels, B., Honecker, J., Schöttl, T., Stecher, L., Klingenspor, M., Hauner, H., & Skurk, T. (2019) · Obesity · doi:10.1002/oby.22435 · Cited by 14
Peng, H., Zhou, Y., Zhang, C., Wang, M., Zhao, S., Xu, Y., Zhang, W., Xin, H., & Wang, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01547d · Cited by 14
Mitochondrial dysfunction in adipocytes: the culprit in type 2 diabetes?
Maassen, J. A. (2006) · Diabetologia · doi:10.1007/s00125-006-0165-z · Cited by 14
Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies
Cheng, Y., Liang, S., Zhang, S., & Hui, X. H. (2024) · Biomedicines · doi:10.3390/biomedicines12071474 · Cited by 13
Miotto, P. M., Frendo‐Cumbo, S., Sacco, S. M., Wright, D. C., Ward, W. E., & Holloway, G. P. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500870 · Cited by 13
Tomczyk, M., Braczko, A., Mierzejewska, P., Podlacha, M., Król, O., Jabłońska, P., Jędrzejewska, A., Pierzynowska, K., Węgrzyn, G., Slominska, E. M., et al. (2022) · Cells · doi:10.3390/cells11172662 · Cited by 13
Dihydrosanguinarine Enhances Glucose Uptake in Mouse 3T3-L1 Cells
Chow, Y., Iwata, Y., & Sato, F. (2017) · ACS Omega · doi:10.1021/acsomega.7b01134 · Cited by 13
Cui, T., Xing, T., Huang, J., Mu, F., Jin, Y., You, X., Chu, Y., Li, H., & Wang, N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01823 · Cited by 13
de Souza, M. C., Agneis, M. L. G., das Neves, K. A., de Almeida, M. R., Feltran, G. D. S., Cruz, E. M. S., Schoffen, J. P. F., Chuffa, L. G. D. A., & Seiva, F. R. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104652 · Cited by 12
Zhao, J., Deliard, S., Aziz, A. R., & Grant, S. F. A. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-89 · Cited by 12
Novelli, E. L. B., Souza, G. A., Ebaid, G. M. X., Rocha, K. K. H. R., Seiva, F. R. F., Mani, F., de Campos, K. E., & Sforcin, J. M. (2009) · Obesity · doi:10.1038/oby.2009.470 · Cited by 12
Lu, K.-Y., Lin, S., Dass, K. T. P., Lin, W.-J., Liu, S., & Harn, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111687 · Cited by 12
Seto, S. W., Lam, T. Y., Leung, G., Au, A. L. S., Ngai, S. M., Chan, S., & Kwan, Y. W. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.070 · Cited by 12
Nazari, M., Khorshidian, A., Alizadeh, S., Falahati, A. M., Haghparast, A., Ghasemifar, S., Babakhanzadeh, E., & Khodadadian, A. (2022) · Human Gene · doi:10.1016/j.humgen.2022.201123 · Cited by 11
Research on the mechanism of microwave-toughened starch on glucolipid metabolism in mice
Li, Y., Liu, W., Xu, Z., Xiao, J., Zong, A., Qiu, B., Jia, M., Liu, L., & Xu, T. (2020) · Food & Function · doi:10.1039/d0fo02093a · Cited by 11
Reyad‐ul‐Ferdous, M., Abdalla, M., & Song, Y. (2022) · Journal of Saudi Chemical Society · doi:10.1016/j.jscs.2022.101454 · Cited by 11
Herbers, E., Patrikoski, M., Wagner, A., Jokinen, R., Hassinen, A., Heinonen, S., Miettinen, S., Peltoniemi, H. H., Pirinen, E., & Pietiläinen, K. H. (2022) · Stem Cells International · doi:10.1155/2022/3308194 · Cited by 11
Mitochondria: Ultrastructure, Dynamics, Biogenesis and Main Functions
Devin, A., Bouchez, C. L., Molinié, T., David, C., Duvezin‐Caubet, S., Rojo, M., Mourier, A., Avéret, N., & Rigoulet, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00001-8 · Cited by 11
Maturation of White Adipose Tissue Function in C57BL/6j Mice From Weaning to Young Adulthood
Kodde, A., Engels, E., Oosting, A., van Limpt, K., van der Beek, E. M., & Keijer, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00836 · Cited by 11
Research and prospect of peptides for use in obesity treatment (Review)
Gao, Y., Yuan, X., Zhu, Z., Wang, D., Liu, Q., & Gu, W. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9364 · Cited by 12
Xiao, Q., Wibowo, T. A., Wu, X., Michal, J. J., Reeves, J. J., Busboom, J. R., Thorgaard, G. H., & Jiang, Z. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.06.021 · Cited by 11
Neuregulin-4, an Adipokine, as a Residual Risk Factor of Atherosclerotic Coronary Artery Disease
Sato, T., & Minatsuki, S. (2019) · International Heart Journal · doi:10.1536/ihj.18-654 · Cited by 10
Zu, Y., Pahlavani, M., Ramalingam, L., Jayarathne, S., Andrade, J., Scoggin, S. O., Festuccia, W. T., Kalupahana, N. S., & Moustaïd‐Moussa, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108708 · Cited by 10
Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer
Lecoutre, S., Clément, K., & Dugail, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020632 · Cited by 10
Yapışlar, H., Hacıosmanoğlu, E., Sarıoğlu, T., & Ekmekçioğlu, C. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101763 · Cited by 10
Quelle, F. W., & Sigmund, C. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.300870 · Cited by 10
Wnt3a regulates mitochondrial biogenesis through p38/CREB pathway
Ning, X., He, J., Shi, X., Yu, T., & Yang, G. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.05.004 · Cited by 10
Role of Mitochondria in Adipose Tissues Metabolism and Plasticity
Carrière, A., & Casteilla, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00007-9 · Cited by 9
Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications
Wang, F., Huynh, P. M., & An, Y. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230009 · Cited by 10
Yesian, A. R., Chalom, M. M., Knudsen, N. H., Hyde, A. L., Personnaz, J., Cho, H., Liou, Y.-H., Starost, K. A., Lee, C., Tsai, D.-Y., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci169152 · Cited by 10
Villarroya, F., Domingo, P., & Giralt, M. (2007) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32810fd785 · Cited by 9
Hogan, H. H., Hutzenbiler, B. D. E., Robbins, C. T., & Jansen, H. T. (2022) · Journal of Comparative Physiology B · doi:10.1007/s00360-021-01428-z · Cited by 9
Croft, A. J., Kelly, C., Chen, D., Haw, T. J., Sverdlov, A. L., & Ngo, D. T. M. (2023) · Antioxidants · doi:10.3390/antiox12051137 · Cited by 9
Tseng, H., Yeh, W., Tu, Y., Yang, B., Lai, Y., Lee, H., Yang, Y.-C., Huang, H., Lee, Y., Ou, C., et al. (2018) · FEBS Letters · doi:10.1002/1873-3468.13061 · Cited by 9
Adipose Tissue Inflammation and Insulin Resistance
Francisco, L., Miriam, H., de Oliveira, A. C., & Alonso‐Vale, M. I. C. (2012) · InTech eBooks · doi:10.5772/53974 · Cited by 9
Festuccia, W. T., & Deshaies, Y. (2009) · Clinical Lipidology · doi:10.2217/clp.09.45 · Cited by 9
Antioxidant peroxiredoxin 3 expression is regulated by 17beta-estradiol in rat white adipose tissue
Bauzá-Thorbrügge, M., M. Galmés-Pascual, B., Sbert-Roig, M., J. García-Palmer, F., Gianotti, M., M. Proenza, A., & Lladó, I. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.05.008 · Cited by 8
Mitochondrial Metabolism and Insulin Action
Turner, N. A. (2013) · InTech eBooks · doi:10.5772/56449 · Cited by 8
Liu, H., Gui, M.-X., Dong, H., Wang, X., & Li, X. (2011) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-011-9468-6 · Cited by 8
Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors
Bayindir‐Buchhalter, I., Wolff, G., Lerch, S., Sijmonsma, T., Schuster, M., Gronych, J., Billeter, A. T., Babaei, R., Krunic, D., Ketscher, L., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708613 · Cited by 8
Sertorio, M. G., Nowrouzi, A., Akbarpour, M., Chetal, K., Salomonis, N., Brons, S., Mascia, A. E., Ionascu, D., McCauley, S., Kupneski, T., et al. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.10.024 · Cited by 8
Sylow, L., Long, J. Z., Lokurkar, I. A., Zeng, X., Richter, E. A., & Spiegelman, B. M. (2016) · Endocrinology · doi:10.1210/en.2016-1398 · Cited by 8
Depot-specific differences in fat mass expansion in WT and ob/ob mice
Wang, X., Yu, C., Feng, J., Chen, J., Jiang, Q. L., Kuang, S., & Wang, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.17938 · Cited by 8
The impact of exercise training on adipose tissue remodelling in cancer cachexia
Ferreira, R. M., Nogueira‐Ferreira, R., Vitorino, R. M. P., Santos, L. L., & Moreira‐Gonçalves, D. (2017) · Porto Biomedical Journal · doi:10.1016/j.pbj.2017.02.006 · Cited by 8
Kumar, R., Chinala, A., Grandhe, D., Endicott, S. J., Garcia, M. A., Campen, M. J., & Gullapalli, R. R. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126844 · Cited by 7
Metadata
- Authors
- Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- University of Pennsylvania (US)
- Corresponding author
- Corvera, Silvia
- Venue
- Journal of Clinical Investigation
- Published
- 2004-11-01
- Volume
- 114
- Issue
- 9
- Pages
- 1281-1289
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC524228
- OpenAlex
- W2022473709
- Cited by
- 616
- References
- 32
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 21 · 2023: 19 · 2022: 23 · 2021: 17 · 2020: 34 · 2019: 22 · 2018: 28 · 2017: 32 · 2016: 32 · 2015: 36 · 2014: 42 · 2013: 44 · 2012: 33
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK60837-02)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial remodeling, adipose tissue, obesity, rosiglitazone, white adipocytes, ob/ob mice, insulin sensitivity, energy homeostasis, mitochondrial mass, mitochondrial structure, oxygen consumption, palmitate oxidation, lipid utilization, 3T3-L1 adipocytes, mitochondrial gene expression
- MeSH terms
- Rosiglitazone, Adipose Tissue, Animals, Blood Glucose, Fatty Acids, Insulin, Mice, Inbred C57BL, Mice, Obese, Mice, Transgenic, Microscopy, Fluorescence, Mitochondria, Obesity, Oxygen, RNA, Messenger, Mass Spectrometry, Time Factors, Vasodilator Agents, Blotting, Northern, Blotting, Western, Adipocytes, RNA, Complementary, Chaperonin 60, Palmitic Acid, Oligonucleotide Array Sequence Analysis, 3T3-L1 Cells, Thiazolidinediones, PPAR gamma, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review