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Cited by 764

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Cardiac autophagy is a maladaptive response to hemodynamic stress

Open access
Zhu, Hongxin, Tannous, Paul, Johnstone, Janet L., Kong, Yongli, Shelton, John M., Richardson, James A., Le, Vien, Levine, Beth, Rothermel, Beverly A., Hill, Joseph A.·2007·Journal of Clinical Investigation
DOI 10.1172/jci27523
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Abstract

Cardiac hypertrophy is a major predictor of heart failure and a prevalent disorder with high mortality. Little is known, however, regarding mechanisms governing the transition from stable cardiac hypertrophy to decompensated heart failure. Here, we tested the role of autophagy, a conserved pathway mediating bulk degradation of long-lived proteins and cellular organelles that can lead to cell death. To quantify autophagic activity, we engineered a line of "autophagy reporter" mice and confirmed that cardiomyocyte autophagy can be induced by short-term nutrient deprivation in vivo. Pressure overload induced by aortic banding induced heart failure and greatly increased cardiac autophagy. Load-induced autophagic activity peaked at 48 hours and remained significantly elevated for at least 3 weeks. In addition, autophagic activity was not spatially homogeneous but rather was seen at particularly high levels in basal septum. Heterozygous disruption of the gene coding for Beclin 1, a protein required for early autophagosome formation, decreased cardiomyocyte autophagy and diminished pathological remodeling induced by severe pressure stress. Conversely, Beclin 1 overexpression heightened autophagic activity and accentuated pathological remodeling. Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention.

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Metadata

Authors
Zhu, H., Tannous, P., Johnstone, J. L., Kong, Y., Shelton, J. M., Richardson, J. A., Le, V., Levine, B., Rothermel, B. A., & Hill, J. A.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2007-07-02
Volume
117
Issue
7
Pages
1782-1793
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci27523
OpenAlex
W1976761774
Cited by
764
References
13
FWCI
19.47
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cardiac autophagy is a maladaptive response to hemodynamic stress. https://app.cochat.ai/papers/10.1172/jci27523
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Zhu, H., Tannous, P., Johnstone, J. L., Kong, Y., Shelton, J. M., Richardson, J. A., Le, V., Levine, B., Rothermel, B. A., & Hill, J. A. (2007). Cardiac autophagy is a maladaptive response to hemodynamic stress. Journal of Clinical Investigation. https://doi.org/10.1172/jci27523

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