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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
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Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.
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“In fibrotic diseases it has been shown that the accumulation of ECM components can be driven primarily by inflammatory processes [59].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [59]
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Metadata
- Authors
- Iredale, J. P.
- Affiliations
- Centre for Inflammation Research (GB)
- Corresponding author
- Iredale, John P.
- ORCID
- Iredale, John P.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-03-01
- Volume
- 117
- Issue
- 3
- Pages
- 539-548
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1804370
- OpenAlex
- W2120335459
- Cited by
- 866
- References
- 128
- Citations by year
- 2026: 19 · 2025: 40 · 2024: 45 · 2023: 39 · 2022: 32 · 2021: 39 · 2020: 34 · 2019: 36 · 2018: 39 · 2017: 36 · 2016: 51 · 2015: 63 · 2014: 61 · 2013: 57 · 2012: 55
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Children's Liver Disease Foundation
- Medical Research Council
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- liver fibrosis, wound healing, inflammation, tissue repair, animal models, cell culture model, liver regeneration
- MeSH terms
- Animals, Disease Models, Animal, Extracellular Matrix, Fibroblasts, Humans, Inflammation, Liver Cirrhosis, Liver Cirrhosis, Experimental, Liver Regeneration, Models, Biological, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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