Cited by 407Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance

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Schenk, Simon, Horowitz, Jeffrey F.·2007·Journal of Clinical Investigation

Abstract

Fatty acid oversupply is a key mediator of skeletal muscle insulin resistance in obesity, primarily via accumulation of fatty acid metabolites and activation of proinflammatory pathways. Herein, we demonstrate that fatty acid-induced insulin resistance in humans is completely prevented the day after 1 session of endurance exercise. Because skeletal muscle is the primary site for systemic glucose disposal and is highly susceptible to impaired insulin action by elevated fatty acid availability, we obtained skeletal muscle samples to investigate possible mechanisms mediating this protective effect of exercise. Prevention of fatty acid-induced insulin resistance after exercise accompanied enhanced skeletal muscle protein expression of key lipogenic enzymes and an increase in muscle triglyceride synthesis. Partitioning more fatty acids toward triglyceride synthesis within muscle reduced the accumulation of fatty acid metabolites and suppressed the proinflammatory response in skeletal muscle, as evidenced by decreased phosphorylation and activation of JNK and increased abundance of inhibitor of NF-kappaB alpha (I kappa B-alpha) and I kappa B-beta. We believe this is the first study to demonstrate that 1 session of exercise completely reverses fatty acid-induced insulin resistance in humans. Reversal of insulin resistance accompanied enhanced lipogenic capacity within skeletal muscle, reduced accumulation of highly bioactive fatty acid metabolites, and suppressed activation of proinflammatory pathways known to impair insulin action.

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Research works printed but not linked: 6

  1. Goodpaster, 2001, J. Clin. Endocrinol. Metab., 86, 5755, 10.1210/jcem.86.12.8075 · DOI · Paper page
  2. Cartee, 1989, Am. J. Physiol., 256, E494
  3. Schrauwen, 1998, Am. J. Physiol., 274, E1027
  4. Schrauwen, 1997, Am. J. Physiol., 273, E623
  5. Horowitz, 1999, Am. J. Physiol., 276, E278
  6. Yang, 1987, Am. J. Physiol., 253, E595

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Metadata

Authors
Schenk, S., & Horowitz, J. F.
Affiliations
University of Michigan (US)
Corresponding author
Horowitz, Jeffrey F.
Venue
Journal of Clinical Investigation
Published
2007-06-01
Volume
117
Issue
6
Pages
1690-1698
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2102453677
Cited by
407
References
56
Citations by year
2026: 4 · 2025: 9 · 2024: 9 · 2023: 17 · 2022: 11 · 2021: 15 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 20 · 2016: 20 · 2015: 23 · 2014: 24 · 2013: 32 · 2012: 37
FWCI
11.27
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • University of Michigan (M01-RR00042)
  • National Institutes of Health (5P60 DK20572, DK20572)
  • National Institute of Diabetes and Digestive and Kidney Diseases (5P60DK-20572, P60DK020572)
  • National Center for Research Resources (M-01RR00042, M01RR000042)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
acute exercise, skeletal muscle insulin resistance, triglyceride synthesis, lipogenic enzymes, fatty acid metabolites, pro-inflammatory pathways, JNK activation, NF-κB, IκBα, obesity, endurance exercise, glucose disposal
MeSH terms
Adult, Fatty Acids, Female, Glycerol-3-Phosphate O-Acyltransferase, Humans, Insulin Resistance, Oxidation-Reduction, Stearoyl-CoA Desaturase, Triglycerides, Exercise, Muscle, Skeletal, Inflammation Mediators, Diacylglycerol O-Acyltransferase

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