Cited by 23Muscle metabolism and nutritionAdipose Tissue and MetabolismLipid metabolism and biosynthesis

Lipid homeostasis in exercise

Bosma, Madeleen·2014·Drug Discovery Today

Abstract

Fatty acids (FA) are essential energy substrates during endurance exercise. In addition to systemic supply, intramyocellular neutral lipids form an important source of FA for the working muscle. Endurance exercise training is associated with an increased reliance on lipids as a fuel source, has systemic lipid-lowering effects and results in a remodeling of skeletal muscle lipid metabolism toward increased oxidation, neutral lipid storage and turnover. Interestingly, recent studies have indicated common exercise-induced regulatory pathways for genes involved in skeletal muscle mitochondrial oxidative metabolism and lipid droplet (LD) dynamics. In this review, I discuss lipid homeostasis during acute exercise and adaptations in lipid metabolism upon exercise training in the light of recent advances in the field.

Integrity signals

Registry

Crossref · 10.1016/j.drudis.2014.03.007

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Exercise and nutrition affect the supply and demand aspects of metabolism and have been shown to influence intramyocellular lipid levels in aging and obesity.

    “they affect the supply and demand aspects of metabolism, respectively, and have been shown to influence IMCL levels in both aging and obesity [59, 97, 99, 101, 102].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bosma, M.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Bosma, Madeleen
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2014-07
Volume
19
Issue
7
Pages
1019-1023
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2083986776
Cited by
23
References
68
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2019: 3 · 2018: 3 · 2016: 1 · 2015: 5 · 2013: 1
FWCI
0.20
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
lipid homeostasis, endurance exercise, fatty acid oxidation, intramyocellular lipid, skeletal muscle lipid metabolism, lipid droplets, mitochondrial oxidative metabolism, training effects, fat deposition, energy substrate utilization
MeSH terms
Adipose Tissue, Animals, Homeostasis, Humans, Exercise, Muscle, Skeletal, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review