Lipid homeostasis in exercise
Abstract
Fatty acids (FA) are essential energy substrates during endurance exercise. In addition to systemic supply, intramyocellular neutral lipids form an important source of FA for the working muscle. Endurance exercise training is associated with an increased reliance on lipids as a fuel source, has systemic lipid-lowering effects and results in a remodeling of skeletal muscle lipid metabolism toward increased oxidation, neutral lipid storage and turnover. Interestingly, recent studies have indicated common exercise-induced regulatory pathways for genes involved in skeletal muscle mitochondrial oxidative metabolism and lipid droplet (LD) dynamics. In this review, I discuss lipid homeostasis during acute exercise and adaptations in lipid metabolism upon exercise training in the light of recent advances in the field.
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Exercise and nutrition affect the supply and demand aspects of metabolism and have been shown to influence intramyocellular lipid levels in aging and obesity.
“they affect the supply and demand aspects of metabolism, respectively, and have been shown to influence IMCL levels in both aging and obesity [59, 97, 99, 101, 102].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [99]
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Lipid droplet dynamics in skeletal muscle
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Self-citationTargeting Intramyocellular Lipids to Improve Aging Muscle Function
Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15 · see citing works
“In contrast, healthy, trained individuals exhibit functional metabolic flexibility, and the training-induced increases in the storage and utilization of carbohydrate (glycogen) and lipid [97–99] result in consistent, appropriate utilization of IMCLs.”
- Authors
- Bosma, M.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Bosma, Madeleen
- ORCID
- Bosma, Madeleen
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 19
- Issue
- 7
- Pages
- 1019-1023
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2083986776
- Cited by
- 23
- References
- 68
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2019: 3 · 2018: 3 · 2016: 1 · 2015: 5 · 2013: 1
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- lipid homeostasis, endurance exercise, fatty acid oxidation, intramyocellular lipid, skeletal muscle lipid metabolism, lipid droplets, mitochondrial oxidative metabolism, training effects, fat deposition, energy substrate utilization
- MeSH terms
- Adipose Tissue, Animals, Homeostasis, Humans, Exercise, Muscle, Skeletal, Lipid Metabolism
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