The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell–associated antigens
Open accessAbstract
Injection of apoptotic cells can induce suppression of immune responses to cell-associated antigens. Here, we show that intravenous injection of apoptotic cells expressing a fragment of myelin oligodendrocyte glycoprotein (MOG) reduced MOG-specific T cell response and prevented the development of EAE. Since injected apoptotic cells accumulated initially in the splenic marginal zone (MZ), the role of macrophages in the MZ in immune suppression was examined using transgenic mice in which these cells could be transiently deleted by diphtheria toxin (DT) injection. DT-treated mice became susceptible to EAE even though MOG-expressing apoptotic cells were preinjected. Deletion of the macrophages caused delayed clearance of injected dying cells in the MZ. In wild-type mice, injected apoptotic cells were selectively engulfed by CD8 alpha(+) DCs, which are responsible for suppression of immune responses to cell-associated antigens. In contrast, deletion of macrophages in the MZ caused aberrant phagocytosis of injected dying cells by CD8 alpha(-)CD11b(+) DCs. These results indicate that macrophages in the MZ regulate not only efficient clearance of apoptotic cells but also selective engulfment of dying cells by CD8 alpha(+) DCs and that functional failure of these unique macrophages impairs suppression of immune responses to cell-associated antigens.
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Cites
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“In addition, phagocytosis of apoptotic cells has immunoregulatory effects, including secretion of immunosuppressive cytokines such as TGF-β and IL-10 (28, 29), which may promote immune tolerance to cell-associated antigens.”
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Structure and function of the spleen
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Differential Antigen Processing by Dendritic Cell Subsets in Vivo
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Cited by
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311
Self-citationImmunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176
Macrophages: Development and Tissue Specialization
Varol, C., Mildner, A., & Jung, S. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112220 · Cited by 962
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis
Hirayama, D., Iida, T., & Nakase, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010092 · Cited by 927
Autoimmunity and the Clearance of Dead Cells
Nagata, S., Hanayama, R., & Kawane, K. (2010) · Cell · doi:10.1016/j.cell.2010.02.014 · Cited by 890
Metadata
- Authors
- Miyake, Y., Asano, K., Kaise, H., Uemura, M., Nakayama, M., & Tanaka, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-08-01
- Volume
- 117
- Issue
- 8
- Pages
- 2268-2278
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2113702305
- Cited by
- 320
- References
- 47
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miyake, Y., Asano, K., Kaise, H., Uemura, M., Nakayama, M., & Tanaka, M. (2007). Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell–associated antigens. Journal of Clinical Investigation. https://doi.org/10.1172/jci31990
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