The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis
Open accessAbstract
Macrophages are effector cells of the innate immune system that phagocytose bacteria and secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play an important role in eliminating diseased and damaged cells through their programmed cell death. Generally, macrophages ingest and degrade dead cells, debris, tumor cells, and foreign materials. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes, but also through trophic, regulatory, and repair functions. Recent studies demonstrated that macrophages differentiate from hematopoietic stem cell-derived monocytes and embryonic yolk sac macrophages. The latter mainly give rise to tissue macrophages. Macrophages exist in all vertebrate tissues and have dual functions in host protection and tissue injury, which are maintained at a fine balance. Tissue macrophages have heterogeneous phenotypes in different tissue environments. In this review, we focused on the phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis for a better understanding of the role of tissue macrophages in several pathological conditions.
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Host cells are equipped with a protective mechanism called the antioxidant defense system, which protects macrophages and other uninfected cells from the toxic effects of RNS.
“Fortunately, these host cells are equipped with a protective mechanism called the antioxidant defense system, which protects macrophages and other uninfected cells from the toxic effects of RNS [122].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [122]
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Aronoff, D. M., Serezani, C. H., Carstens, J. K., Marshall, T. M., Gangireddy, S. R., Peters-Golden, M. L., & Reddy, R. C. (2007) · PPAR Research · doi:10.1155/2007/52546 · Cited by 28 · see citing works
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The Role of Reactive Species on Innate Immunity
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“Physiologically, macrophages act via phagocytosis to destroy foreign antigens [30].”
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- Authors
- Hirayama, D., Iida, T., & Nakase, H.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Nakase, Hiroshi
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-12-29
- Volume
- 19
- Issue
- 1
- Pages
- 92
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5796042
- OpenAlex
- W2786954262
- Cited by
- 927
- References
- 101
- Citations by year
- 2026: 71 · 2025: 140 · 2024: 187 · 2023: 161 · 2022: 120 · 2021: 122 · 2020: 80 · 2019: 36 · 2018: 8 · 2013: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (16H06279, 17J02428)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- macrophages, phagocytosis, innate immunity, tissue homeostasis, tissue macrophages, monocyte differentiation, macrophage heterogeneity, tissue damage, macrophage phenotype
- MeSH terms
- Pathogen-Associated Molecular Pattern Molecules, Animals, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Macrophages, Phagocytosis, Cell Lineage, Receptors, Pattern Recognition, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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