Cited by 927Phagocytosis and Immune RegulationImmune cells in cancerAutophagy in Disease and Therapy

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

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Hirayama, Daisuke, Iida, Tomoya, Nakase, Hiroshi·2017·International Journal of Molecular Sciences

Abstract

Macrophages are effector cells of the innate immune system that phagocytose bacteria and secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play an important role in eliminating diseased and damaged cells through their programmed cell death. Generally, macrophages ingest and degrade dead cells, debris, tumor cells, and foreign materials. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes, but also through trophic, regulatory, and repair functions. Recent studies demonstrated that macrophages differentiate from hematopoietic stem cell-derived monocytes and embryonic yolk sac macrophages. The latter mainly give rise to tissue macrophages. Macrophages exist in all vertebrate tissues and have dual functions in host protection and tissue injury, which are maintained at a fine balance. Tissue macrophages have heterogeneous phenotypes in different tissue environments. In this review, we focused on the phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis for a better understanding of the role of tissue macrophages in several pathological conditions.

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  • Host cells are equipped with a protective mechanism called the antioxidant defense system, which protects macrophages and other uninfected cells from the toxic effects of RNS.

    “Fortunately, these host cells are equipped with a protective mechanism called the antioxidant defense system, which protects macrophages and other uninfected cells from the toxic effects of RNS [122].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [122]

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Authors
Hirayama, D., Iida, T., & Nakase, H.
Affiliations
Sapporo Medical University (JP)
Corresponding author
Nakase, Hiroshi
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-12-29
Volume
19
Issue
1
Pages
92
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2786954262
Cited by
927
References
101
Citations by year
2026: 71 · 2025: 140 · 2024: 187 · 2023: 161 · 2022: 120 · 2021: 122 · 2020: 80 · 2019: 36 · 2018: 8 · 2013: 1
FWCI
3.48
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (16H06279, 17J02428)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
macrophages, phagocytosis, innate immunity, tissue homeostasis, tissue macrophages, monocyte differentiation, macrophage heterogeneity, tissue damage, macrophage phenotype
MeSH terms
Pathogen-Associated Molecular Pattern Molecules, Animals, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Macrophages, Phagocytosis, Cell Lineage, Receptors, Pattern Recognition, Host-Pathogen Interactions

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