The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
Open accessAbstract
Forkhead box O (Foxo) transcription factors govern metabolism and cellular differentiation. Unlike Foxo-dependent metabolic pathways and target genes, the mechanisms by which these proteins regulate differentiation have not been explored. Activation of Notch signaling mimics the effects of Foxo gain of function on cellular differentiation. Using muscle differentiation as a model system, we show that Foxo physically and functionally interacts with Notch by promoting corepressor clearance from the Notch effector Csl, leading to activation of Notch target genes. Inhibition of myoblast differentiation by constitutively active Foxo1 is partly rescued by inhibition of Notch signaling while Foxo1 loss of function precludes Notch inhibition of myogenesis and increases myogenic determination gene (MyoD) expression. Accordingly, conditional Foxo1 ablation in skeletal muscle results in increased formation of MyoD-containing (fast-twitch) muscle fibers and altered fiber type distribution at the expense of myogenin-containing (slow-twitch) fibers. Notch/Foxo1 cooperation may integrate environmental cues through Notch with metabolic cues through Foxo1 to regulate progenitor cell maintenance and differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“previously reported role for FoxOs in cellular fate determination observed in myogenesis and hematopoiesis (Hu et al., 2008; Kitamura et al., 2007; Tothova et al., 2007).”
From FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis (2009) · cites this paper as Kitamura et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562
Self-citationMolecular diversity of myofibrillar proteins: gene regulation and functional significance
Schiaffino, S., & Reggiani, C. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.2.371 · Cited by 1,545
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Self-citation(2004) · doi:10.1016/s0092-8674(04)00452-0 · Cited by 1,356
Self-citationControl of endodermal endocrine development by Hes-1
Jensen, J. N., Pedersen, E. E., Galante, P. E., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155
Notch signaling is essential for vascular morphogenesis in micePreprint
Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,065
Self-citationFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032
Self-citationSuppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a
Castrillón, D. H., Miao, L., Kollipara, R., Horner, J. W., & DePinho, R. A. (2003) · Science · doi:10.1126/science.1086336 · Cited by 984
Self-citationConboy, I. M., & Rando, T. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00254-x · Cited by 905
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2196 · Cited by 852
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 823
The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation
Nakae, J., Kitamura, T., Kitamura, Y., Biggs, W., Arden, K. C., & Accili, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00401-x · Cited by 729
Self-citationHosaka, T., Biggs, W., Tieu, D. D., Boyer, A. D., Varki, N. M., Cavenee, W. K., & Arden, K. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400093101 · Cited by 684
Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2620 · Cited by 678
Nakae, J., Kitamura, T., Silver, D. L., & Accili, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12876 · Cited by 652
Self-citationNakae, J., Kitamura, T., Silver, D. L., & Accili, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112876 · Cited by 652
Self-citationMastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover
Fryer, C. J., White, B., & Jones, K. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.014 · Cited by 627
Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W., Wright, C. V. E., White, M. F., Arden, K. C., & Accili, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16857 · Cited by 584
Self-citationA histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint
Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
Potente, M., Urbich, C., Sasaki, K., Hofmann, W. K., Heeschen, C., Aicher, A., Kollipara, R., DePinho, R. A., Zeiher, A. M., & Dimmeler, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23126 · Cited by 527
Self-citationKitamura, T., Nakae, J., Kitamura, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200216857 · Cited by 479
Self-citationThe MyoD family of transcription factors and skeletal myogenesis
Rudnicki, M. A., & Jaenisch, R. (1995) · BioEssays · doi:10.1002/bies.950170306 · Cited by 450
Hughes, S. M., Taylor, J. M., Tapscott, S. J., Gurley, C. M., Carter, W. J., & Peterson, C. A. (1993) · Development · doi:10.1242/dev.118.4.1137 · Cited by 422
Control of muscle development by dueling HATs and HDACs
McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00224-0 · Cited by 414
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
Shawber, C. J., Nofziger, D., Hsieh, J. J.-D., Lindsell, C. E., Bögler, O., Hayward, D. W., & Weinmaster, G. (1996) · Development · doi:10.1242/dev.122.12.3765 · Cited by 367
Self-citationNickoloff, B. J., Qin, J.-Z., Chaturvedi, V., Denning, M. F., Bonish, B. K., & Miele, L. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401036 · Cited by 330
Pan, Y., Lin, M., Tian, X., Cheng, H., Gridley, T., Shen, J., & Kopan, R. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.014 · Cited by 326
Nickoloff, B. J., Osborne, B. A., & Miele, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206758 · Cited by 308
Masking of the CBF1/RBPJ κ Transcriptional Repression Domain by Epstein-Barr Virus EBNA2
Hsieh, J. J.-D., & Hayward, S. D. (1995) · Science · doi:10.1126/science.7725102 · Cited by 295
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
Nofziger, D., Miyamoto, A., Lyons, K. M., & Weinmaster, G. (1999) · Development · doi:10.1242/dev.126.8.1689 · Cited by 294
Essential Role of Endothelial Notch1 in Angiogenesis
Limbourg, F. P., Takeshita, K., Radtke, F., Bronson, R. T., Chin, M. T., & Liao, J. K. (2005) · Circulation · doi:10.1161/01.cir.0000160870.93058.dd · Cited by 281
Recognition sequence of a highly conserved DNA binding protein RBP-J x
Tun, T., Hamaguchi, Y., Matsunami, N., Furukawa, T., Honjo, T., & Kawaichi, M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.6.965 · Cited by 281
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis
Kuroda, K., Tani, S., Tamura, K., Minoguchi, S., Kurooka, H., & Honjo, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7238 · Cited by 273
Regulation of PGC-1 Promoter Activity by Protein Kinase B and the Forkhead Transcription Factor FKHR
Daitoku, H., Yamagata, K., Matsuzaki, H., Hatta, M., & Fukamizu, A. (2003) · Diabetes · doi:10.2337/diabetes.52.3.642 · Cited by 262
Liang, Y., Chang, J. L., Lynch, S. J., Lukac, D. M., & Ganem, D. (2002) · Genes & Development · doi:10.1101/gad.996502 · Cited by 245
Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways
Dowell, P., Otto, T. C., Adi, S., & Lane, M. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309069200 · Cited by 235
Lai, E. C. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf170 · Cited by 231
Notch function in the vasculature: insights from zebrafish, mouse and man
Shawber, C. J., & Kitajewski, J. (2004) · BioEssays · doi:10.1002/bies.20004 · Cited by 214
Self-citationHribal, M. L., Nakae, J., Kitamura, T., Shutter, J. R., & Accili, D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212107 · Cited by 203
Self-citationNOTCH Signaling as a Novel Cancer Therapeutic Target
Miele, L., Miao, H., & Nickoloff, B. J. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906777441771 · Cited by 200
Phenotypic Modulation of Smooth Muscle Cells through Interaction of Foxo4 and Myocardin
Liu, Z.-P., Wang, Z., Yanagisawa, H., & Olson, E. N. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.017 · Cited by 192
Accili, D. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1633 · Cited by 171
Self-citationLoss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size
Knapp, J. R., Davie, J. K., Myer, A., Meadows, E., Olson, E. N., & Klein, W. H. (2006) · Development · doi:10.1242/dev.02249 · Cited by 167
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
Kovall, R. A., & Hendrickson, W. A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600349 · Cited by 155
Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation
Hirsinger, E., Malapert, P., Dubrulle, J., Delfini, M.-C., Duprez, D., Henrique, D., Ish‐Horowicz, D., & Pourquié, O. (2001) · Development · doi:10.1242/dev.128.1.107 · Cited by 148
Dual Roles for the Notch Target Gene Hes-1 in the Differentiation of 3T3-L1 Preadipocytes
Ross, D. A., Rao, P. K., & Kadesch, T. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3505-3513.2004 · Cited by 147
Wilson‐Rawls, J., Molkentin, J. D., Black, B. L., & Olson, E. N. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2853 · Cited by 135
The Leading Edge of Stem Cell Therapeutics
Singeç, I., Jandial, R., Crain, A., Nikkhah, G., & Snyder, E. Y. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.58.070605.115252 · Cited by 126
Ogilvie, R. W., & Feeback, D. L. (1990) · Stain Technology · doi:10.3109/10520299009105613 · Cited by 116
Notch Signaling in Primary Endothelial Cells
Shawber, C. J., Das, I., FRANCISCO, E., & Kitajewski, J. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03219.x · Cited by 98
Self-citationNotch Oncoproteins Depend on γ-Secretase/Presenilin Activity for Processing and Function
Das, I., Craig, C. M., Funahashi, Y., Jung, K., Kim, T.-W., Byers, R. J., Weng, A. P., Kutok, J. L., Aster, J. C., & Kitajewski, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309252200 · Cited by 70
Self-citationGenomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene.
Kawaichi, M., Oka, C., Shibayama, S., Koromilas, A. E., Matsunami, N., Hamaguchi, Y., & Honjo, T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50626-3 · Cited by 40
Chi, T., Yan, Z., Xue, Y., & Wang, W. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)77018-9 · Cited by 11
Flagged first, then by citations
Cited by
Sorted by citations
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415
Self-citationCellular and molecular mechanisms of muscle atrophy
Bonaldo, P., & Sandri, M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010389 · Cited by 1,284
Calnan, D. R., & Brunet, A. (2008) · Oncogene · doi:10.1038/onc.2008.21 · Cited by 1,170
Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816
“FoxO1 null in muscle (HSA-Cre) Viable Normal growth, slow to fast switch in muscle [ 134 ,135]”
Background
Metadata
- Authors
- Kitamura, T., Kitamura, Y. I., Funahashi, Y., Shawber, C. J., Castrillon, D. H., Kollipara, R., DePinho, R. A., Kitajewski, J., & Accili, D.
- Affiliations
- Gunma University (JP)
- Columbia University (US)
- Harvard University (US)
- Corresponding author
- Accili, Domenico
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2477-2485
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1950461
- OpenAlex
- W2045736879
- Cited by
- 285
- References
- 54
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 15 · 2023: 7 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 17 · 2016: 14 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 31
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK63608, DK57539)
- National Heart, Lung, and Blood Institute (R01HL062454)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK057539, DK63608, K01DK074629, DK-64819, DK 57539, P30DK063608, R01DK064819)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- FOXO1, Notch signaling, myogenesis, MyoD, myogenin, CSL transcription factor, fast-twitch muscle, slow-twitch muscle, transcriptional regulation
- MeSH terms
- Forkhead Box Protein O1, Animals, Cell Differentiation, Cell Line, Gene Expression Regulation, Mice, Transgenic, Muscle Proteins, Nuclear Proteins, Promoter Regions, Genetic, Protein Binding, Transcription Factors, Signal Transduction, Muscle, Skeletal, Muscle Development, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Forkhead Transcription Factors, Receptor, Notch1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
