Cited by 736Adipokines, Inflammation, and Metabolic DiseasesAngiogenesis and VEGF in CancerAdipose Tissue and Metabolism

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Angiogenesis modulates adipogenesis and obesity

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Cao, Yihai·2007·Journal of Clinical Investigation

DOI 10.1172/jci32239PMC PMC1963348

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Abstract

Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.

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See all 736

Authors: Cao, Y.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Cao, Yihai
ORCID: Cao, Yihai
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-09-04
Volume: 117
Issue: 9
Pages: 2362-2368
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci32239
PMC: PMC1963348
OpenAlex: W2027442301
Cited by: 736
References: 120
Citations by year: 2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
FWCI: 21.41
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Swedish Cancer Foundation
European Commission
Hjärt-Lungfonden
Karolinska Institutet
Vetenskapsrådet
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
MeSH terms: Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis

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