The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
Open accessAbstract
We used a panel of monoclonal antibodies to characterize DCs in the dermis of normal human skin. Staining for the CD11c integrin, which is abundant on many kinds of DCs, revealed cells in the upper dermis. These cells were positive for blood DC antigen-1 (BDCA-1; also known as CD1c), HLA-DR, and CD45, markers that are also expressed by circulating myeloid DCs. A small subset of CD11c+ dermal cells expressed DEC-205/CD205 and DC-lysosomal-associated membrane glycoprotein/CD208 (DC-LAMP/CD208), suggesting some differentiation or maturation. When BDCA-1+ cells were selected from collagenase digests of normal dermis, they proved to be strong stimulators for T cells in a mixed leukocyte reaction. A second major population of cells located throughout the dermis was positive for factor XIIIA (FXIIIA), but lacked CD11c and BDCA-1. They expressed the macrophage scavenger receptor CD163 and stained weakly for HLA-DR and CD45. Isolated CD163+ dermal cells were inactive in stimulating T cell proliferation, but in biopsies of tattoos, these cells were selectively laden with granular pigments. Plasmacytoid DCs were also present in the dermis, marked by CD123 and BDCA-2. In summary, the normal dermis contains typical immunostimulatory myeloid DCs identified by CD11c and BDCA-1, as well as an additional population of poorly stimulatory macrophages marked by CD163 and FXIIIA.
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Cites
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Ligand recognition by antigen-presenting cell C-type lectin receptors
McGreal, E. P., Miller, J. L., & Gordon, S. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.12.001 · Cited by 310
Granelli-Piperno, A., Pritsker, A., Pack, M., Shimeliovich, I., Arrighi, J.-F., Park, C. G., Trumpfheller, C., Piguet, V., Moran, T. M., & Steinman, R. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4265 · Cited by 208
Self-citation
Cited by
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Lowes, M. A., Suárez-Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,650
Self-citationSeneschal, J., Clark, R. A., Gehad, A., Baecher-Allan, C. M., & Kupper, T. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.018 · Cited by 455
Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., et al. (2014) · Nature Immunology · doi:10.1038/ni.2769 · Cited by 295
Human dermal CD14(+) cells are a transient population of monocyte-derived macrophages
McGovern, N., Schlitzer, A., Gunawan, M., Jardine, L., Shin, A., Poyner, E., Green, K., Dickinson, R., Wang, X.-N., Low, D., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.006 · Cited by 281
Metadata
- Authors
- Zaba, L. C., Fuentes-Duculan, J., Steinman, R. M., Krueger, J. G., & Lowes, M. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2517-2525
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2017583377
- Cited by
- 300
- References
- 3
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zaba, L. C., Fuentes-Duculan, J., Steinman, R. M., Krueger, J. G., & Lowes, M. A. (2007). Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages. Journal of Clinical Investigation. https://doi.org/10.1172/jci32282
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