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Cited by 295

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

Open access
Abtin, Arby, Jain, Rohit, Mitchell, Andrew J, Roediger, Ben, Brzoska, Anthony J, Tikoo, Shweta, Cheng, Qiang, Ng, Lai Guan, Cavanagh, Lois L, von Andrian, Ulrich H, Hickey, Michael J, Firth, Neville, Weninger, Wolfgang·2014·Nature Immunology
DOI 10.1038/ni.2769
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Abstract

Transendothelial migration of neutrophils in postcapillary venules is a key event in the inflammatory response against pathogens and tissue damage. The precise regulation of this process is incompletely understood. We report that perivascular macrophages are critical for neutrophil migration into skin infected with the pathogen Staphylococcus aureus. Using multiphoton intravital microscopy we showed that neutrophils extravasate from inflamed dermal venules in close proximity to perivascular macrophages, which are a major source of neutrophil chemoattractants. The virulence factor α-hemolysin produced by S. aureus lyses perivascular macrophages, which leads to decreased neutrophil transmigration. Our data illustrate a previously unrecognized role for perivascular macrophages in neutrophil recruitment to inflamed skin and indicate that S. aureus uses hemolysin-dependent killing of these cells as an immune evasion strategy.

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Crossref · 10.1038/ni.2769

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Metadata

Authors
Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., Hickey, M. J., Firth, N., & Weninger, W.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2013-11-24
Volume
15
Issue
1
Pages
45-53
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
DOI
10.1038/ni.2769
OpenAlex
W2017418319
Cited by
295
References
47
FWCI
14.79
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection. https://app.cochat.ai/papers/10.1038/ni.2769
The paper
Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., Hickey, M. J., Firth, N., & Weninger, W. (2014). Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection. Nature Immunology. https://doi.org/10.1038/ni.2769

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.