The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
Open accessAbstract
The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are ineffective against strains that have undergone significant antigenic variation. An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. To determine how common cross-reactive T cells are, we performed a comprehensive ex vivo analysis of cross-reactive CD4+ and CD8+ memory T cell responses to overlapping peptides spanning the full proteome of influenza A/Viet Nam/CL26/2005 (H5N1) and influenza A/New York/232/2004 (H3N2) in healthy individuals from the United Kingdom and Viet Nam. Memory CD4+ and CD8+ T cells isolated from the majority of participants exhibited human influenza-specific responses and showed cross-recognition of at least one H5N1 internal protein. Participant CD4+ and CD8+ T cells recognized multiple synthesized influenza peptides, including peptides from the H5N1 strain. Matrix protein 1 (M1) and nucleoprotein (NP) were the immunodominant targets of cross-recognition. In addition, cross-reactive CD4+ and CD8+ T cells recognized target cells infected with recombinant vaccinia viruses expressing either H5N1 M1 or NP. Thus, vaccine formulas inducing heterosubtypic T cell-mediated immunity may confer broad protection against avian and human influenza A viruses.
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Cites
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Cited by
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., Dejnirattisai, W., Rostron, T., Supasa, P., Liu, C., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0782-6 · Cited by 1,179
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Self-citationHuman memory T cells: generation, compartmentalization and homeostasis
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Cellular immune correlates of protection against symptomatic pandemic influenza
Sridhar, S., Begom, S., Bermingham, A., Hoschler, K., Adamson, W., Carman, W., Bean, T., Barclay, W., Deeks, J. J., & Lalvani, A. (2013) · Nature Medicine · doi:10.1038/nm.3350 · Cited by 862
Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1
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Metadata
- Authors
- Lee, L. Y.-H., Ha, D. L. A., Simmons, C., de Jong, M. D., Chau, N. V. V., Schumacher, R., Peng, Y. C., McMichael, A. J., Farrar, J. J., Smith, G. L., Townsend, A. R. M., Askonas, B. A., Rowland-Jones, S., & Dong, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-09-18
- Volume
- 118
- Issue
- 10
- Pages
- 3478-90
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2071375294
- Cited by
- 422
- References
- 62
- FWCI
- 27.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, L. Y.-H., Ha, D. L. A., Simmons, C., de Jong, M. D., Chau, N. V. V., Schumacher, R., Peng, Y. C., McMichael, A. J., Farrar, J. J., Smith, G. L., Townsend, A. R. M., Askonas, B. A., Rowland-Jones, S., & Dong, T. (2008). Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. Journal of Clinical Investigation. https://doi.org/10.1172/jci32460
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
