WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias

(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196

Epithelial-mesenchymal transition and its implications for fibrosis

Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715

More powerful procedures for multiple significance testing

Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

Selman, M., King, T. E., & Pardo, A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-2-200101160-00015 · Cited by 1,807

WNT and β-catenin signalling: diseases and therapies

Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763

Idiopathic Pulmonary Fibrosis: Clinical Relevance of Pathologic Classification

KATZENSTEIN, A.-L. A., & MYERS, J. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707039 · Cited by 1,261

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

Kim, K. K., Kugler, M. C., Wolters, P. J., Robillard, L., Galvez, M. G., Brumwell, A. N., Sheppard, D., & Chapman, H. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605669103 · Cited by 1,257

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

Phillips, R. J., Burdick, M. D., Hong, K. M., Lutz, M., Murray, L. A., Xue, Y., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20997 · Cited by 1,071

TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease

Willis, B. C., & Borok, Z. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00163.2007 · Cited by 1,064

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Shi, J., Chi, S., Xue, J., Yang, J., Li, F., & Liu, X. (2016) · Journal of Immunology Research · doi:10.1155/2016/9392132 · Cited by 122

Tissue remodelling in pulmonary fibrosis

Knudsen, L., Ruppert, C., & Ochs, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2543-2 · Cited by 121

Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis

Schiller, H. B., Mayr, C. H., Leuschner, G., Strunz, M., Staab-Weijnitz, C. A., Preisendörfer, S., Eckes, B., Moinzadeh, P., Krieg, T. M., Schwartz, D. A., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201611-2263oc · Cited by 118

Viral infection and aging as cofactors for the development of pulmonary fibrosis

Naik, P. K., & Moore, B. B. (2010) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.73 · Cited by 118

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

Beyer, C., Reichert, H., Akan, H., Mallano, T., Schramm, A., Dees, C., Palumbo‐Zerr, K., Lin, N., Distler, A., Gelse, K., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202544 · Cited by 117

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of β-Catenin

Chang, W., Wei, K., Jacobs, S. S., Upadhyay, D., Weill, D., & Rosen, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025684 · Cited by 116

Transforming Growth Factor-β Signaling across Ages: From Distorted Lung Development to Chronic Obstructive Pulmonary Disease

Morty, R. E., Königshoff, M., & Eickelberg, O. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200908-087rm · Cited by 115

Wnt Coreceptor Lrp5 is a Driver of Idiopathic Pulmonary Fibrosis

Lam, A. P., Herazo‐Maya, J. D., Sennello, J. A., Flozak, A. S., Russell, S., Mutlu, G. M., Budinger, G. R. S., DasGupta, R., Varga, J., Kaminski, N., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201401-0079oc · Cited by 115

Activation of Wnt/β‐catenin signalling is required for TGF‐β/Smad2/3 signalling during myofibroblast proliferation

Xu, L., Cui, W., Zhou, W., Li, D., Li, L., Zhao, P., Mo, X., Zhang, Z., & Gao, J. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13085 · Cited by 113

Prospects for new lung cancer treatments that target EMT signaling

Otsuki, Y., Saya, H., & Arima, Y. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24596 · Cited by 113

miR‐9‐5p suppresses pro‐fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2

Fierro‐Fernández, M., Busnadiego, Ó., Sandoval, P., Espinosa‐Díez, C., Blanco, E. M., Rodríguez, M., Pian, H. G., Ramos, R., López‐Cabrera, M., García‐Bermejo, L., et al. (2015) · EMBO Reports · doi:10.15252/embr.201540750 · Cited by 112

Biomarkers in idiopathic pulmonary fibrosis

Zhang, Y., & Kaminski, N. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328356d03c · Cited by 113

Nicotine-induced epithelial-mesenchymal transition via Wnt/β-catenin signaling in human airway epithelial cells

Zou, W., Zou, Y., Zhao, Z., Li, B., & Ran, P. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00094.2012 · Cited by 107

Biology and Treatment of Aggressive Fibromatosis or Desmoid Tumor

Skubitz, K. M. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.02.012 · Cited by 106

A Role for Wnt Signaling Genes in the Pathogenesis of Impaired Lung Function in Asthma

Sharma, S., Tantisira, K. G., Carey, V. J., Murphy, A., Lasky-Su, J. A., Celedon, J. C., Lazarus, R. M., Klanderman, B. J., Rogers, A. J., Soto-Quirós, M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1009oc · Cited by 105

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles

Parimon, T., Yao, C., Habiel, D. M., Ge, L., Bora, S. A., Brauer, R., Evans, C. M., Xie, T., Alonso-Valenteen, F., Medina‐Kauwe, L. K., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129359 · Cited by 108

WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease

Berschneider, B., & Königshoff, M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.11.013 · Cited by 105

Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT ‐associated COPD pathogenesis

Mahmood, M. Q., Reid, D. W., Ward, C., Muller, H. K., Knight, D. A., Sohal, S. S., & Walters, E. H. (2016) · Respirology · doi:10.1111/resp.12882 · Cited by 104

miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence

Cui, H., Ge, J., Xie, N., Banerjee, S., Zhou, Y., Antony, V. B., Thannickal, V. J., & Liu, G. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0163oc · Cited by 104

WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family

Maiese, K. (2014) · Current Neurovascular Research · doi:10.2174/1567202611666140912115107 · Cited by 105

CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer

Gürbüz, I., & Chiquet‐Ehrismann, R. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.03.007 · Cited by 100

SNAI transcription factors mediate epithelial-mesenchymal transition in lung fibrosis

Jayachandran, A., Königshoff, M., Yu, H., Rupniewska, E., Hecker, M., Klepetko, W., Seeger, W., & Eickelberg, O. (2009) · Thorax · doi:10.1136/thx.2009.121798 · Cited by 100

β-Catenin in the Alveolar Epithelium Protects from Lung Fibrosis after Intratracheal Bleomycin

Tanjore, H., Degryse, A. L., Crossno, P. F., Xu, X. C., McConaha, M. E., Jones, B. R., Polosukhin, V. V., Bryant, A. J., Cheng, D., Newcomb, D. C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201205-0972oc · Cited by 99

Interstitial Lung Disease in Scleroderma

Schoenfeld, S. R., & Castelino, F. V. (2015) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2014.12.005 · Cited by 99

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

Pak, O., Scheibe, S., Esfandiary, A., Gierhardt, M., Sydykov, A. S., Logan, A., Fysikopoulos, A., Veit, F., Hecker, M., Kroschel, F., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01024-2017 · Cited by 95

AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice

Pan, J., Li, H., Guo, J., Wang, X., Liu, D., Tian, J., Zhang, M., & An, F. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.005 · Cited by 93

miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis

Berschneider, B., Ellwanger, D. C., Baarsma, H. A., Thiel, C., Shimbori, C., White, E. S., Kolb, M. R. J., Neth, P., & Königshoff, M. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.06.011 · Cited by 91

The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues

Foronjy, R., & Majka, S. M. (2012) · Cells · doi:10.3390/cells1040874 · Cited by 92

Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis

Lang, N. J., Gote-Schniering, J., Porras-Gonzalez, D., Yang, L., Sadeleer, L. D., Jentzsch, R. C., Shitov, V. A., Zhou, S., Ansari, M., Agami, A., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adh0908 · Cited by 101

Tobacco Smoke–Induced Lung Fibrosis and Emphysema

Morse, D., & Rosas, I. O. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170411 · Cited by 90

Axin Pathway Activity Regulates in Vivo pY654-β-catenin Accumulation and Pulmonary Fibrosis

Ulsamer, A., Wei, Y., Kim, K. K., Tan, K., Wheeler, S. E., Xi, Y., Thies, R. S., & Chapman, H. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322123 · Cited by 83

Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

Königshoff, M., Dumitrascu, R., Udalov, S., Amarie, O. V., Reiter, R., Grimminger, F., Seeger, W., SCHERMULY, R. T., & Eickelberg, O. (2010) · Thorax · doi:10.1136/thx.2009.134353 · Cited by 83

The matricellular protein CCN1 enhances TGF‐β1/SMAD3‐dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury

Kurundkar, A., Kurundkar, D., Rangarajan, S., Locy, M. L., Zhou, Y., Liu, R.-M., Zmijewski, J. W., & Thannickal, V. J. (2016) · The FASEB Journal · doi:10.1096/fj.201500173 · Cited by 85

Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity

Cosín‐Roger, J., Ortiz‐Masiá, D., & Barrachina, M. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02297 · Cited by 80

Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis

Chapman, M., Mukund, K., Subramaniam, S., Brenner, D. A., & Lieber, R. L. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00226.2016 · Cited by 83

Dysfunctional Resident Lung Mesenchymal Stem Cells Contribute to Pulmonary Microvascular Remodeling

Chow, K. S., Fessel, J. P., Ihida‐Stansbury, K., Schmidt, E. P., Gaskill, C. F., Alvarez, D. F., Graham, B. B., Harrison, D. G., Wagner, D. H., Nozik‐Grayck, E., et al. (2013) · Pulmonary Circulation · doi:10.4103/2045-8932.109912 · Cited by 76

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

Elkouris, M., Kontaki, H., Stavropoulos, A., Antonoglou, A., Nikolaou, K. C., Samiotaki, M. K., Szántai, E., Saviolaki, D., Brown, P. J., Sideras, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.051 · Cited by 75

Wnt/β-catenin signaling: A novel target for therapeutic intervention of fibrotic kidney disease

Hwang, I., Seo, E.-Y., & Ha, H. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-2200-3 · Cited by 76

The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis

Pullamsetti, S. S., Savai, R., Dumitrascu, R., Dahal, B. K., Wilhelm, J., Königshoff, M., Zakrzewicz, D., Ghofrani, H. A., Weißmann, N., Eickelberg, O., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001725 · Cited by 76

Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2

Chen, X., Shi, C., Meng, X., Zhang, K., Li, X., Wang, C., Xiang, Z., Hu, K., & Han, X. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.04.003 · Cited by 74

Activation of the Wnt/β-Catenin Signaling Pathway by Mechanical Ventilation Is Associated with Ventilator-Induced Pulmonary Fibrosis in Healthy Lungs

Villar, J., Cabrera-Benítez, N. E., Valladares, F., Casula, M., Flores, C., Blanch, L. L., Quílez, M. E., Santana-Rodríguez, N., Kacmarek, R. M., & Slutsky, A. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023914 · Cited by 73

Breakdown of Epithelial Barrier Integrity and Overdrive Activation of Alveolar Epithelial Cells in the Pathogenesis of Acute Respiratory Distress Syndrome and Lung Fibrosis

Yanagi, S., Tsubouchi, H., Miura, A., Matsumoto, N., & Nakazato, M. (2015) · BioMed Research International · doi:10.1155/2015/573210 · Cited by 71

Reconstructing dynamic microRNA-regulated interaction networks

Schulz, M. H., Pandit, K. V., Cardenas, C. L. L., Ambalavanan, N., Kaminski, N., & Bar‐Joseph, Z. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303236110 · Cited by 71

The CCN family acting throughout the body: recent research developments

Kubota, S., & Takigawa, M. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2013-0018 · Cited by 71

WNT Signaling in Lung Aging and Disease

Lehmann, M., Baarsma, H. A., & Königshoff, M. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201608-586aw · Cited by 70

Loss of Secreted Frizzled-Related Protein-1 Leads to Deterioration of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy

Sklepkiewicz, P. L., Shiomi, T., Kaur, R., Sun, J., Kwon, S. H., Mercer, B. A., Bodine, P. V. N., SCHERMULY, R. T., George, I., Schulze, P. C., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001274 · Cited by 71

WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts

Klee, S., Lehmann, M., Wagner, D. E., Baarsma, H. A., & Königshoff, M. (2016) · Scientific Reports · doi:10.1038/srep20547 · Cited by 69

The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections

Yanagi, S., Tsubouchi, H., Miura, A., Matsuo, A., Matsumoto, N., & Nakazato, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030503 · Cited by 74

Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis

Trinh‐Minh, T., Chen, C.-W., Manh, C. T., Li, Y., Zhu, H., Zhou, X., Chakraborty, D., Zhang, Y., Rauber, S., Dees, C., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci159884 · Cited by 71

Canonical Wnt signalling as a key regulator of fibrogenesis – implications for targeted therapies?

Dees, C., & Distler, J. H. W. (2013) · Experimental Dermatology · doi:10.1111/exd.12255 · Cited by 69

Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD

Heijink, I. H., de Bruin, H. G., Dennebos, R., Jonker, M. R., Noordhoek, J. A., Brandsma, C., van den Berge, M., & Postma, D. S. (2016) · European Respiratory Journal · doi:10.1183/13993003.01541-2015 · Cited by 67

miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions

Cui, H., Ge, J., Xie, N., Banerjee, S., Zhou, Y., Liu, R.-M., Thannickal, V. J., & Liu, G. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00335.2016 · Cited by 66

WISP1/CCN4: A Potential Target for Inhibiting Prostate Cancer Growth and Spread to Bone

Ono, M., Inkson, C. A., Sonn, R., Kilts, T. M., de Castro, L. F., Maeda, A., Fisher, L. W., Robey, P. G., Berendsen, A. D., Li, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071709 · Cited by 66

Canonical Wnt signaling in systemic sclerosis

Bergmann, C., & Distler, J. H. W. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2015.154 · Cited by 69

WNT receptor signalling in lung physiology and pathology

Skrońska-Wąsek, W., Gosens, R., Königshoff, M., & Baarsma, H. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.009 · Cited by 66

Mesenchymal Stem Cell Therapy of Pulmonary Fibrosis

Chuang, H.-M., Shih, T. E., Lu, K.-Y., Tsai, S.-F., Harn, H., & Ho, L. (2018) · Cell Transplantation · doi:10.1177/0963689718787501 · Cited by 64

Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis

Liu, T., Santos, F. G. D. L., Hirsch, M., Wu, Z., & Phan, S. H. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0499oc · Cited by 66

Wnt Signaling and Aging-Related Heart Disorders

Naito, A. T., Shiojima, I., & Komuro, I. (2010) · Circulation Research · doi:10.1161/circresaha.110.223776 · Cited by 64

ALMS1-Deficient Fibroblasts Over-Express Extra-Cellular Matrix Components, Display Cell Cycle Delay and Are Resistant to Apoptosis

Zulato, E., Favaretto, F., Veronese, C., Campanaro, S., Marshall, J. D., Romano, S., Cabrelle, A., Collin, G. B., Zavan, B., Belloni, A. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019081 · Cited by 65

Towards a functional proteomics approach to the comprehension of idiopathic pulmonary fibrosis, sarcoidosis, systemic sclerosis and pulmonary Langerhans cell histiocytosis

Landi, C., Bargagli, E., Bianchi, L., Gagliardi, A., Carleo, A., Bennett, D., Perari, M. G., Armini, A., Prasse, A., Rottoli, P., et al. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.03.006 · Cited by 63

MicroRNAs in non-small cell lung cancer and idiopathic pulmonary fibrosis

Mizuno, K., Mataki, H., Seki, N., Kumamoto, T., Kamikawaji, K., & Inoue, H. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2016.98 · Cited by 63

Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways

Rojas, M. M., Mora, A. L., Kapetanaki, M. G., Weathington, N. M., Gladwin, M. T., & Eickelberg, O. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201508-484pl · Cited by 64

Endogenous Lung Regeneration: Potential and Limitations

Rock, J. R., & Königshoff, M. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1151pp · Cited by 64

Idiopathic Pulmonary Fibrosis: Pathobiology of Novel Approaches to Treatment

Maher, T. M. (2011) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2011.11.002 · Cited by 65

Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities

Krupska, I., Bruford, E. A., & Chaqour, B. (2015) · Human Genomics · doi:10.1186/s40246-015-0046-y · Cited by 63

Thermodynamic Aspects and Reprogramming Cellular Energy Metabolism during the Fibrosis Process

Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122537 · Cited by 61

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity

Königshoff, M. (2011) · Respiration · doi:10.1159/000326299 · Cited by 59

WISP1 Neuroprotection Requires FoxO3a Post-Translational Modulation with Autoregulatory Control of SIRT1

Wang, S., Zhong Chong, Z., Chen Shang, Y., & Maiese, K. (2013) · Current Neurovascular Research · doi:10.2174/156720213804805945 · Cited by 58

WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial–mesenchymal transition

Deng, W., Fernández, A., McLaughlin, S. L., & Klinke, D. J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006122 · Cited by 58

Enolase 1 and protein disulfide isomerase associated 3 regulate Wnt/β-catenin driven alveolar epithelial cell trans-differentiation

Mutze, K., Vierkotten, S., Milošević, J., Eickelberg, O., & Königshoff, M. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.019117 · Cited by 58

Recent Advances in Understanding the Pathogenesis of Scleroderma-Interstitial Lung Disease

Akter, T., Silver, R. M., & Bogatkevich, G. S. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0411-1 · Cited by 57

The Divergent Roles of Secreted Frizzled Related Protein-1 (SFRP1) in Lung Morphogenesis and Emphysema

Foronjy, R., Imai, K., Shiomi, T., Mercer, B. A., Sklepkiewicz, P. L., Thankachen, J., Bodine, P. V. N., & D'Armiento, J. M. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090803 · Cited by 57

Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury

Villar, J., Cabrera-Benítez, N. E., Ramos-Nuez, Á., Flores, C., García‐Hernández, S., Valladares, F., López‐Aguilar, J., Blanch, L. L., & Slutsky, A. S. (2014) · Critical Care · doi:10.1186/s13054-014-0568-z · Cited by 57

The molecular pathogenesis of morphoea: from genetics to future treatment targets

Saracino, A., Denton, C. P., & Orteu, C. H. (2016) · British Journal of Dermatology · doi:10.1111/bjd.15001 · Cited by 58

Conjunction junction, what’s the function? CCN proteins as targets in fibrosis and cancers

Leask, A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00028.2020 · Cited by 60

Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing

Blokland, K. E. C., Waters, D. W., Schuliga, M. J., Read, J. M., Pouwels, S. D., Grainge, C., Jaffar, J., Westall, G. P., Mutsaers, S. E., Prêle, C. M., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040389 · Cited by 58

CCN4 Regulates Vascular Smooth Muscle Cell Migration and Proliferation

Liu, H., Dong, W., Lin, Z., Lu, J., Wan, H., Zhou, Z., & Liu, Z. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0012-2 · Cited by 56

Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells

Shin, J. A., Chung, J. S., Cho, S.-H., Kim, H. J., & Yoo, Y. D. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.012 · Cited by 56

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

Zhang, H., Luo, H., Hu, Z., Peng, J., Jiang, Z., Song, T., Wu, B., Yue, J., Zhou, R., Xie, R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3358 · Cited by 56

Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype

Jara, P., Calyeca, J., Romero, Y., Plácido, L., Yu, G., Kaminski, N., Maldonado, V., Cisneros, J., Selman, M., & Pardo, A. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00043.2014 · Cited by 56

Mucins as a New Frontier in Pulmonary Fibrosis

Ballester, B., Milara, J., & Cortijo, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091447 · Cited by 59

Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis

Froidure, A., Marchal‐Duval, E., Homps-Legrand, M., Ghanem, M., Justet, A., Crestani, B., & Mailleux, A. (2020) · European Respiratory Review · doi:10.1183/16000617.0140-2019 · Cited by 61

Heterogeneous distribution of mechanical stress in human lung: A mathematical approach to evaluate abnormal remodeling in IPF

Carloni, A., Poletti, V. E., Fermo, L., Bellomo, N., & Chilosi, M. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.04.038 · Cited by 55

Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury

Zemans, R. L., McClendon, J. D., Aschner, Y., Briones, N. J., Young, S. K., Lau, L. F., Kahn, M., & Downey, G. P. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00180.2012 · Cited by 56

Impact of Transcriptomics on Our Understanding of Pulmonary Fibrosis

Vukmirovic, M., & Kaminski, N. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00087 · Cited by 56

Pulmonary CCR2+CD4+T cells are immune regulatory and attenuate lung fibrosis development

Milger, K., Yu, Y., Brudy, E., Irmler, M., Skapenko, A., Mayinger, M. C., Lehmann, M., Beckers, J., Reichenberger, F., Behr, J., et al. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-208423 · Cited by 54

Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways

Blaauboer, M. E., Emson, C. L., Verschuren, L., van Erk, M., Turner, S., Everts, V. E., Hanemaaijer, R., & Stoop, R. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.04.005 · Cited by 53

Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

Lee, J.-U., Cheong, H. S., Shim, E., Bae, D.-J., Chang, H. S., Uh, S., Kim, Y., Park, J., Lee, B., Shin, H. D., et al. (2017) · Respiratory Research · doi:10.1186/s12931-016-0493-6 · Cited by 53

Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction

Gaskill, C. F., Carrier, E. J., Kropski, J. A., Bloodworth, N. C., Menon, S., Foronjy, R., Taketo, M. M., Hong, C. C., Austin, E. D., West, J. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88629 · Cited by 53

Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection

Ashirbekov, Y., Abaildayev, A., Omarbayeva, N., Botbayev, D. M., MARATOVICH, B. A., Askandirova, A., Neupokoyeva, A. S., Utegenova, G., Sharipov, K. O., & Аitkhozhinа, N. А. (2020) · PeerJ · doi:10.7717/peerj.10494 · Cited by 53

Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis

Oda, K., Yatera, K., Izumi, H., Ishimoto, H., Yamada, S., Nakao, H., Hanaka, T., Ogoshi, T., Noguchi, S., & Mukae, H. (2016) · Respiratory Research · doi:10.1186/s12931-016-0357-0 · Cited by 53

Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury

Ding, X., Tong, Y., Jin, S., Chen, Z., Li, T., Billiar, T. R., Pitt, B. R., Li, Q., & Zhang, L. (2018) · Critical Care · doi:10.1186/s13054-018-2237-0 · Cited by 52

Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation

Györfi, A., Matei, A., Fuchs, M., Liang, C., Rigau, A. R., Hong, X., Zhu, H., Luber, M., Bergmann, C., Dees, C., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201916 · Cited by 56

Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

Zhang, X. Z., Zhang, Y., Tao, B., Teng, L. S., Li, Y., Cao, R., Gui, Q., Ye, M., Mou, X., Cheng, H., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-200139 · Cited by 51

Overexpression of Pax6 in Mouse Cornea Directly Alters Corneal Epithelial Cells: Changes in Immune Function, Vascularization, and Differentiation

Davis, J. A., & Piatigorsky, J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6726 · Cited by 51

Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling

Ota, C., Baarsma, H. A., Wagner, D. E., Hilgendorff, A., & Königshoff, M. (2016) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-016-0062-6 · Cited by 51

Dendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis

Chia, D. J., Zhu, T., Chyou, S., Dasoveanu, D., Carballo, C. B., Tian, S., MAGRO, C. M. J., Rodeo, S. A., Spiera, R., Ruddle, N. H., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85740 · Cited by 52

Fibrosis: Lessons from OMICS analyses of the human lung

Yu, G., Ibarra, G. H., & Kaminski, N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.014 · Cited by 52

Nanotransfection-based vasculogenic cell reprogramming drives functional recovery in a mouse model of ischemic stroke

Lemmerman, L. R., Balch, M. H. H., Moore, J. T., Alzate‐Correa, D., Rincon‐Benavides, M. A., Salazar‐Puerta, A. I., Gnyawali, S. C., Harris, H. N., Lawrence, W. R., Ortega‐Pineda, L., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd4735 · Cited by 51

The WNT1 induced signalling protein 1 is a novel mediator of impaired epithelial-mesenchymal interactions in lung fibrosis

Königshoff, M., & Justus Liebig University Giessen (2009) · University writing server of the Justus Liebig University Giessen (Justus-Liebig-Universität Gießen) · doi:10.22029/jlupub-13464

Regulation of WISP1 by profibrotic cytokines in pulmonary fibrosis

Klee, S., Aumiller, V., Berschneider, B., & Königshoff, M. (2014) · European Respiratory Journal · doi:10.1183/13993003/erj.44.suppl_58.1417 · Cited by 1

Role of the WNT/beta-catenin signal pathway in idiopathic and experimental pulmonary fibrosis

Balsara, N., & Justus Liebig University Giessen (2013) · University writing server of the Justus Liebig University Giessen (Justus-Liebig-Universität Gießen) · doi:10.22029/jlupub-11875

WISP1: A novel regulator of idiopathic pulmonary fibrosis amenable to therapeutic intervention

Königshoff, M., Jahn, A., Kitowska, K., Amarie, O. V., Rose, F., Fink, L., Seeger, W., Guenther, A., & Eickelberg, O. (2007) · Pneumologie · doi:10.1055/s-2007-1032272

Expression and activity of WNT1 - inducible signalling protein-1 in idiopathic pulmonary fibrosis

Ambler, L. J. (2016) · ePrints Soton (University of Southampton)