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Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress
Open accessAbstract
In several disease states, abnormal growth of blood vessels is associated with local neuronal degeneration. This is particularly true in ocular diseases such as retinal angiomatous proliferation (RAP) and macular telangiectasia (MacTel), in which, despite the absence of large-scale leakage or hemorrhage, abnormal neovascularization (NV) is associated with local neuronal dysfunction. We describe here a retinal phenotype in mice with dysfunctional receptors for VLDL (Vldlr-/- mice) that closely resembles human retinal diseases in which abnormal intra- and subretinal NV is associated with photoreceptor cell death. Such cell death was evidenced by decreased cone and, to a lesser extent, rod opsin expression and abnormal electroretinograms. Cell death in the region of intraretinal vascular abnormalities was associated with an increased presence of markers associated with oxidative stress. Oral antioxidant supplementation protected against photoreceptor degeneration and preserved retinal function, despite the continued presence of abnormal intra- and subretinal vessels. What we believe to be novel, Müller cell-based, virally mediated delivery of neurotrophic compounds specifically to sites of NV was also neuroprotective. These observations demonstrate that neuronal loss secondary to NV can be prevented by the use of simple antioxidant dietary measures or cell-based delivery of neurotrophic factors, even when the underlying vascular phenotype is not altered.
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“Stress (GFAP promoter) or hypoxia-driven GFAP promoters (HRSE-6xHRE-GfaABC1D) have been generated that might be safer for cells that are sensitive to continuous overexpressed artificial gene vectors [96,97,99,100,102].”
From Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays (2020) · cites this paper as [100]
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Cites
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261
The epidemiology of age-related macular degeneration
Klein, R., Peto, T., Bird, A., & Vannewkirk, M. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.069 · Cited by 932
Self-citationRETINAL ANGIOMATOUS PROLIFERATION IN AGE–RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2012) · Retina · doi:10.1097/iae.0b013e31823f9b3b · Cited by 660
RETINAL ANGIOMATOUS PROLIFERATION IN AGE-RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2001) · Retina · doi:10.1097/00006982-200110000-00003 · Cited by 658
Protein-bound acrolein: Potential markers for oxidative stress
Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4882 · Cited by 632
Involvement of oxidative stress in Alzheimer disease
Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1439 · Cited by 549
Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study.
Gass, J. D. M., & Blodi, B. A. (1993) · PubMed · Cited by 507
Flagged first, then by citations
Research works printed but not linked: 3
- Dorrell, 2002, Invest. Ophthalmol. Vis. Sci., 43, 3500
- Shen, 2007, Histol. Histopathol., 22, 1301
- Ferrara, 2005., EXS., 209
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Teng, L., Sun, Y., Teng, S., & Hui, P. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37626 · Cited by 8
Dong, Y., Cai, X., Wu, Y., Liu, Y., Deng, L., & Chen, H. (2017) · PubMed · Cited by 8
COMBINATION ANGIOSTATIC THERAPIES
Friedlander, M. (2009) · Retina · doi:10.1097/iae.0b013e3181ad2673 · Cited by 8
Self-citationXiao, X., Zhuang, X., Xu, C., Chen, H., Zhu, W., Pang, C., & Zhang, M. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.35797 · Cited by 7
Kim, J., Kim, C., Jo, K., Cho, Y.-S., Kim, H.-G., Lee, G., Lee, Y. M., Sohn, E., & Kim, J. S. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.033 · Cited by 7
Cliver, R. N., Castro, N., Russomano, T., Lardieri, G., Quarrie, L., van der Merwe, H., & Vázquez, M. (2022) · Neuroglia · doi:10.3390/neuroglia3030006 · Cited by 6
Advances in Treatment and Management: Immunologic and Cell-Based Regenerative Therapies
Friedlander, M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9483p · Cited by 5
Self-citationRetinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels
Tzaridis, S., Aguilar, E., Dorrell, M. I., Friedlander, M., & Eade, K. (2024) · Angiogenesis · doi:10.1007/s10456-024-09954-4 · Cited by 3
Self-citationCerium Oxide Nanoparticle Reduction of Oxidative Damage in Retina
Cai, X., Seal, S., & McGinnis, J. F. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-606-7_19 · Cited by 2
NRF2 and Age-Dependent RPE Degeneration
Chen, Y., Zhao, Z., Sternberg, P. W., & Cai, J. (2012) · InTech eBooks · doi:10.5772/28167 · Cited by 2
Stem Cells and Cellular Therapy
Friedlander, M., & Hinton, D. R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00035-7 · Cited by 2
Self-citationBerger, T. A., Manry, M. W., Lindsell, L. B., Osher, J. M., Miller, D. M., Foster, R. E., Riemann, C. D., Petersen, M. R., & Sisk, R. A. (2021) · Clinical ophthalmology · doi:10.2147/opth.s294789 · Cited by 1
Galdamez, A., Park, S., Temme, W., Bradley, A., Stevenson, E., Chea, L., Lee, E.-J., & Lin, J. H. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.11.21 · Cited by 1
Cell Therapy for Ophthalmic Diseases
Kauper, K., & Nystuen, A. (2017) · Molecular and translational medicine · doi:10.1007/978-3-319-57153-9_12 · Cited by 1
Adeno-associated Viral Vectors in the Retina: Delivering Gene Therapy to the Right Destination
Rudnick, N. D., Kim, L. A., & Comander, J. (2022) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000416 · Cited by 1
Cai, X., Sezate, S. A., Seal, S., & McGinnis, J. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.102 · Cited by 1
RetractedCastillo-Padilla, D. V., & Rivas-Arancibia, S. (2011) · Archivos de Neurociencias
Defining Novel Mechanisms in Cardiovascular Development
Plein, A. (2015) · UCL Discovery (University College London)
Animal and Human Models of Retinal Diseases
Fletcher, E. L., Pébay, A., Rutar, M., Kakavand, K., Wang, A. Y., Vessey, K. A., Jobling, A. I., & Greferath, U. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24191-6
Effect of degeneration stage on non-viral tissue transfection of rd10 retina ex vivo
Zhang, J., Bing, Z., Marie, C., Izsvák, Z., Müller, F. U., Thumann, G., Walter, P., & Johnen, S. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102616
Patel, Y., Baumann, B., & Merkle, C. W. (2025) · Biomedical Optics Express · doi:10.1364/boe.574030
Evolution dirigée de virus adéno-associés pour un transfert de gène efficace dans le système visuel
Planul, A. (2017) · theses.fr (ABES) · doi:10.70675/c9b178a1z8ba4z4451za409z4e80a603376f
Impact d'une exposition prénatale à l'alcool sur le développement de la rétine.
Dumanoir, M. (2021) · theses.fr (ABES) · doi:10.70675/8e4b1cfdzd2c7z4197zbda8z76e7ad8f87f5
Feng, Z., Pan, M., Liu, H., Liu, M., Yang, J., Wang, C., Yao, R., Liu, H., & Fu, Y. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103727
Liu, Y., Tang, J., Zhao, J., Hu, Y., Zhou, Z., Yu, Z., Luo, X., Zheng, M., Ying, G., & Zhang, G. (2026) · Ophthalmology Science · doi:10.1016/j.xops.2026.101412
Ceapin‐ A7 Suppresses UPR Signaling and Mitigates Retinal Neovascularization in Vldlr −/− Mice
Park, S., Galdamez, A., Temme, W., Bradley, A., Le, M., Chea, L., Stevenson, E., Gradilla, Y., Lee, E.-J., & Lin, J. H. (2026) · The FASEB Journal · doi:10.1096/fj.202603175r
Metadata
- Authors
- Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G., & Friedlander, M.
- Affiliations
- Scripps Research Institute (US)
- University of Michigan (US)
- Hadassah Medical Center (IL)
- Moorfields Eye Hospital (GB)
- Corresponding author
- Friedlander, Martin
- Venue
- Journal of Clinical Investigation
- Published
- 2009-03-02
- Volume
- 119
- Issue
- 3
- Pages
- 611-623
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2648679
- OpenAlex
- W1999304307
- Cited by
- 127
- References
- 57
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 15 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 15
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- California Institute for Regenerative Medicine
- V. Kann Rasmussen Foundation
- National Institutes of Health
- National Eye Institute (R01EY011254)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- neovascularization, oxidative stress, photoreceptor degeneration, retinal angiomatous proliferation, macular telangiectasia, VLDL receptor, antioxidant supplementation, neurotrophic factor delivery, Müller cells, viral gene delivery, retinal function, cone opsin, rod opsin, electroretinogram
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Electroretinography, Mice, Inbred C57BL, Nerve Growth Factors, Receptors, LDL, Retina, Retinitis Pigmentosa, Rhodopsin, Lipid Peroxidation, Retinal Neovascularization, Gene Expression, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Gene Transfer Techniques, Mice, Knockout, Oxidative Stress, Angiogenesis Inhibitors, Gene Expression Profiling, Vascular Endothelial Growth Factor A, Mice, Aptamers, Nucleotide, Retinal Pigment Epithelium, Opsins
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