Cited by 459Parathyroid Disorders and TreatmentsAlkaline Phosphatase Research StudiesBone health and osteoporosis research

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Endocrine functions of bone in mineral metabolism regulation

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Quarles, L. Darryl·2008·Journal of Clinical Investigation

DOI 10.1172/jci36479PMC PMC2586800

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Abstract

Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological requirements. This review examines the newly discovered signaling pathways involved in the endocrine functions of bone, such as those mediated by the phosphaturic and 1,25(OH)2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calcium and phosphate homeostasis.

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Authors: Quarles, L. D.
Affiliations: University of Kansas Medical Center (US)
Corresponding author: Quarles, L. Darryl
ORCID: Quarles, L. Darryl
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2008-12-01
Volume: 118
Issue: 12
Pages: 3820-3828
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci36479
PMC: PMC2586800
OpenAlex: W2165433745
Cited by: 459
References: 117
Citations by year: 2026: 7 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 17 · 2020: 19 · 2019: 37 · 2018: 28 · 2017: 19 · 2016: 22 · 2015: 19 · 2014: 28 · 2013: 26 · 2012: 65
FWCI: 5.74
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045955, R01-AR-45955, R56AR045955)
Topics: Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: bone endocrine function, mineral metabolism, calcium homeostasis, phosphate homeostasis, fibroblast growth factor 23, 1,25-dihydroxyvitamin D, bone mineralization, hyperphosphatemia, skeletal mass
MeSH terms: Fibroblast Growth Factor-23, Animals, Bone and Bones, Calcitriol, Calcium, Energy Metabolism, Fibroblast Growth Factors, Homeostasis, Humans, Phosphates, Bone Density, Hyperphosphatemia

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