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Endocrine functions of bone in mineral metabolism regulation
Open accessAbstract
Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological requirements. This review examines the newly discovered signaling pathways involved in the endocrine functions of bone, such as those mediated by the phosphaturic and 1,25(OH)2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calcium and phosphate homeostasis.
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“These cells are able to regulate phosphate metabolism by the production of FGF23, which acts on other organs including parathyroid gland and kidneys to reduce the circulating levels of phosphates [208, 209].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [208]
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Metadata
- Authors
- Quarles, L. D.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Quarles, L. Darryl
- ORCID
- Quarles, L. Darryl
- Venue
- Journal of Clinical Investigation
- Published
- 2008-12-01
- Volume
- 118
- Issue
- 12
- Pages
- 3820-3828
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2586800
- OpenAlex
- W2165433745
- Cited by
- 459
- References
- 117
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 17 · 2020: 19 · 2019: 37 · 2018: 28 · 2017: 19 · 2016: 22 · 2015: 19 · 2014: 28 · 2013: 26 · 2012: 65
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045955, R01-AR-45955, R56AR045955)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- bone endocrine function, mineral metabolism, calcium homeostasis, phosphate homeostasis, fibroblast growth factor 23, 1,25-dihydroxyvitamin D, bone mineralization, hyperphosphatemia, skeletal mass
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Bone and Bones, Calcitriol, Calcium, Energy Metabolism, Fibroblast Growth Factors, Homeostasis, Humans, Phosphates, Bone Density, Hyperphosphatemia
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